Biomedical subjects
Publications and source records attributed to C W Fox.
Many disorders and abnormalities are accompanied by cavitary lesions of the lung, including various diseases that may destroy or replace lung tissue. The most common causes of cavitary lung disease are primary and metastatic neoplasms, granulomas, and necrotizing pulmonary infections. These diseases often have radiographic patterns, clinical signs, and symptoms that are characteristic and may suggest a diagnosis.
After a steady decline in incidence during most of this century, tuberculosis case rates stabilized in the mid-1980s, and since then have steadily increased. Several factors may have been responsible for the increase, including the influx of immigrants from endemic areas and the appearance of AIDS. This review outlines the current recommendations for treatment of tuberculosis in the otherwise normal patient, then discusses special problems which may affect treatment, including primary drug failure and relapse, pregnancy and lactation, extrapulmonary disease, AIDS, renal failure, and liver disease. The appearance and significance of multiple-drug-resistant tuberculosis (MDRT) in AIDS victims is discussed, and current recommendations for screening patients for the presence of tuberculosis are reviewed.
A case of recurrent rhabdomyosarcoma in an adult is reported. The primary disease at presentation was in the maxillary sinus with metastatic spread to regional lymph nodes. A complete response (CR) and a 14-month disease-free interval (DFI) were obtained with combination therapy. The sole site of relapse was an intratesticular mass. Management implications are discussed.
Seminal vesicle abscesses are extremely rare and worthy of report. Computerized tomography easily verifies the diagnosis and simplifies the treatment of transurethral incision and drainage.
Techniques were described for fabricating maxillary and mandibular protrusive positioners for treatment of disk-condyle derangements. Treatment time with the splints varies from 4 to 12 months depending on the age of the patient, the degree of existing symptoms, and patient motivation. At the end of the treatment period and after removal of the splints, the patient may have (1) no pain or internal derangement, (2) no pain but internal derangement with or without reduction, or (3) pain and internal derangement with or without reduction. If dental treatment is required, patients in the first two categories can be treated at a physiologically acceptable treatment position with existing treatment modalities. For patients in the third category, definitive, irreversible stabilization should be reevaluated. For these patients a mandibular cast splint can be changed to an interim splint by replacing the self-polymerizing resin with Isosit (Ivoclar-Vivadent, Schaan, Liechtenstein) or heat-processed acrylic resin.
Lecithin agar was developed on which phospholipase C produced turbid zones and phospholipase A produced clear zones. Reactions on lecithin agar agreed 74% of the time with reactions in egg yolk broth. On lecithin agar, interpretation was easier, phospholipase A was detectable, and opaque zones were visible 1 or 2 days earlier than on egg yolk agar. All constituents of the medium can be autoclaved.
Bacteria which produced phospholipase C were isolated from 13 of 34 fresh and 15 of 35 spoiled samples of homogenized milk. No single off flavor was assigned consistently to samples with phospholipase producers, but 75% of them were bitter. Pseudomonads constituted 62% of the isolates. Other phospholipase C-producing genera and their numbers were Acinetobacter, two; Alcaligenes, three; Bacillus, two; Citrobacter, one; Enterobacter, three; and Flavobacterium, two. Two unidentified yeasts also were isolated.
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