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C W Griffin

Publications and source records attributed to C W Griffin.

6 recordsLinked to original sources
PubMed1989

Cardiotonic agents. 5. Fragments from the heterocycle-phenyl-imidazole pharmacophore.

To examine the role of each component in the heterocycle-phenyl-imidazole inotropic pharmacophore, several imidazolone derivatives, an arylimidazole, a substituted 3,4-dihydro-4-oxopyrimidine, and a quinolin-2(1H)-one derivative were prepared as structural fragments or representatives from this relationship. Tests for cardiac inotropic activity in ferret papillary muscle strips (FPM) and for inhibition of crude cAMP phosphodiesterase obtained from canine cardiac tissue suggest that, while all three components contribute significantly toward potent activity (active at less than 1 microM concentrations in FPM), any combination of two components, in approximately a preferred geometry, represents the minimal requirements for weak activity (active at less than 25 microM concentrations). No single component appears to be requisite in an absolute sense.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1986

Relationship between performance in three of the Centers for Disease Control microbiology proficiency testing programs and the number of actual patient specimens tested by participating laboratories.

The performance of laboratories enrolled in three of the Centers for Disease Control microbiology performance evaluation programs was studied in relation to the number of actual patient specimens tested by the laboratories. Laboratories were grouped according to the number of specimens tested weekly to compare performance among the groups. Results of the study showed that laboratories, as a group, that tested large numbers of specimens performed better than laboratories that tested small numbers. The infrequency of performing certain tests or identifying certain microbial species can be an important factor in laboratory error. One strategy for laboratories that cannot resolve internal problems associated with low testing volumes would be to limit their testing to procedures that are done well.

Bacteriology↗
PubMed1986

Centers for Disease Control performance evaluation program in bacteriology: 1980 to 1985 review.

This report presents a summary and analysis of data from the Centers for Disease Control performance evaluation program in bacteriology for the 6-year period 1980 to 1985. During this period, the number of laboratories enrolled in the program ranged from about 750 to 1,000. Identification results reported by participating laboratories for representative species of six major groups of bacteria were placed into five response categories that were based on the level and accuracy of the identifications. Data on the performance of participants with bacterial groups and performance with selected species within each major group were analyzed. Overall, participants experienced the least difficulty in identifying species or serogroups of members of the gram-positive and gram-negative cocci. Participants encountered greater difficulties with anaerobes, gram-positive bacilli, and miscellaneous gram-negative bacteria. Identification of members of the family Enterobacteriaceae was of moderate difficulty. Problems in identifying certain bacterial species were probably related to a number of factors such as the characteristics of the species, its frequency of occurrence, the state of technology available for identification, and the state of proficiency and quality control in individual laboratories at the time of testing. Examples are given of improvements over time in the identification of certain bacterial species. Laboratories participating in an external proficiency testing program should take full advantage of the benefits of participation by instituting measures to correct testing deficiencies identified by the program.

Bacteria↗