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Biomedical subjects

C W Hutton

Publications and source records attributed to C W Hutton.

33 records · Page 2Linked to original sources
PubMed1987

Intra-articular variation of synovial changes in knee arthritis: biopsy study comparing changes in patellofemoral synovium and the medial tibiofemoral synovium.

Variation of synovial changes in the knee joint was studied in 23 patients. Histological features of biopsies taken from the patellofemoral joint synovium were compared with biopsies taken from the synovium of the medial tibiofemoral joint. The patellofemoral compartment showed more fibrosis compared to the medial tibiofemoral compartment where there was more inflammatory cell infiltration, pigmentation, an increase in vascularity, increased fragment deposition and synovial hyperplasia. Multiple biopsy with reference to compartmental localization is likely to give more information than biopsy of a single site.

Arthritis↗
PubMed1987

Isolation and analysis of complement activating aggregates from synovial fluid of patients with rheumatoid arthritis using monoclonal anti-C3d antibodies.

The complement activating aggregates in synovial fluids of patients with rheumatoid arthritis (RA) have been isolated using monoclonal IgM anti-C3d antibodies attached to solid phases, and the content of the material bound has been analysed. High levels of aggregated IgG bearing C3d were found in RA synovial fluids, and IgG was the major immunoglobulin bound from such synovial fluids by anti-C3d Sepharose. A strong correlation was shown between levels of aggregated IgG bearing C3d and complement activation, as judged by C3d levels. Significant (but less strong) relationships were also observed between C3d levels and both complement consuming and C1q binding activity. C3d levels and levels of aggregated IgG bearing C3d were both significantly associated with the numbers of polymorphonuclear leucocytes (PMNs) found in RA synovial fluids. From these results it is concluded that the aggregated immunoglobulins bearing C3d (particularly IgG) isolated from RA synovial fluids are responsible for activating complement and attracting PMNs into the joint space. Radioimmunoassay showed no correlation, however, between levels of aggregated IgG (or IgM) bearing C3d and rheumatoid factor (RF) activity bound by anti-C3d. In addition, the material bound by anti-C3d Sepharose from most synovial fluid polyethylene glycol precipitates did not contain either IgM or IgG RF. Thus both techniques show that the majority of complexes bearing C3d do not contain RF. As the complement fixing aggregates apparently contain only immunoglobulin and complement components the results raise the problem of how the aggregates are formed. It is suggested that RA IgG may remain aggregated after either antigen or antibody (RF) has dissociated from the complex.

Antibodies, Monoclonal↗
PubMed1986

99mTc HMDP bone scanning in generalised nodal osteoarthritis. I. Comparison of the standard radiograph and four hour bone scan image of the hand.

The pattern of joint involvement on conventional radiographs and the four hour gammacamera image of 99Tc HMDP bone scans were studied in 33 patients with generalised nodal osteoarthritis. Both techniques showed the predominant involvement of the distal interphalangeal, scaphotrapezial, and first carpometacarpal joints. Some joints were abnormal just on one investigation: either x ray or scan alone. Others showed a marked dissimilarity in the severity of involvement on x ray compared with scan. This discrepancy between x ray and scan suggests that the scan is imaging a different process than the radiograph and offers a different way of assessing change in osteoarthritis.

Female↗
PubMed1986

99mTc HMDP bone scanning in generalised nodal osteoarthritis. II. The four hour bone scan image predicts radiographic change.

In 14 patients with generalised nodal osteoarthritis a four hour bone scan image was found to predict the changes that occur on the radiograph at follow up between three and five years later. The scan abnormality appeared to precede the development of radiographic signs, and joints abnormal on scintigraphy showed most progression. Normal joints and joints abnormal on x ray alone showed little progression, and those that did subsequently alter became abnormal on scan. Scanning may provide a sensitive technique for monitoring osteoarthritis, it may enable a greater understanding of the underlying disease process, and allow evaluation of modifying therapeutic procedures.

Female↗
PubMed1985

Systemic response to local urate crystal induced inflammation in man: a possible model to study the acute phase response.

The production of a systemic inflammatory response to intradermal monosodium urate crystal injection is described. A transient, self-limiting local response is associated with a systemic response detectable by a rise in the white cell count and serum amyloid A protein. The white cell change parallels the evolution of the local response, whereas the serum amyloid A response lags behind the local lesion, peaking after the local lesion is resolving. Intradermal monosodium urate injection is proposed as a possible inflammatory stimulus to explore the acute phase protein response in different disease states.

Acute Disease↗
PubMed1984

Apatite associated destructive arthritis.

Twelve patients, 11 women and one man, aged 66-83, with a distinctive type of destructive arthropathy are described. The principal joints affected were the shoulders (ten) and knees (seven). Clinical features included pain on use, large cool effusions, instability and rapid progression. Radiographs showed attrition of bone and cartilage with a paucity of reparative changes. Synovial fluids were viscous, with low cell counts, and stained positively for the presence of apatite-containing particles. Extensive calcific material was seen in the synovium of the four patients biopsied, and on the radiographs in seven. Most patients had some associated or preceding joint disorder. The literature on similar cases is reviewed, and the possible role of crystals and other aetiological factors is discussed. It is suggested that a characteristic form of large-joint atrophy can occur in elderly patients at a number of joint sites and in several different clinical settings.

Aged↗
PubMed1984

Mononuclear phagocytes in rheumatoid arthritis: Fc-receptor expression by peripheral blood monocytes.

Fc receptor expression by enriched monocytes from rheumatoid arthritis (RA) patients and age and sex matched controls (healthy subjects) was compared by measuring the uptake of IgG on monocytes in a competitive radioassay. The association constant (Ka) between IgG and the monocytes and the number of Fc binding sites per cell was calculated from Scatchard plots of 4 degrees C binding data. RA monocytes had increased expression of Fc receptors as compared with those of controls. This increase was particularly pronounced in those RA patients affected by extra-articular disease. There were significant correlations between the numbers of Fc receptors on monocytes and both C1q binding and anticomplementary activity but none between monocyte Fc receptor numbers and serum rheumatoid factors (IgG and IgM). It is considered that monocyte handling of circulating immune complexes is unimpaired in RA and that monocytes make an adaptive response to increased levels of immune complexes.

Aged↗
PubMed1984

Osteosarcoma of breast recurring with mediastinal obstruction.

A case of osteogenic sarcoma of the breast in an 82-year-old woman is described. It was treated by simple mastectomy but recurred and caused mediastinal obstruction. Radiotherapy gave only mild symptomatic benefit. Previous publications in osteosarcoma of the breast are reviewed.

Aged↗
PubMed1983

Assessment of the zinc nutritional status of selected elderly subjects.

Elderly participants (with a mean age range of 71 to 75 years) residing in two housing complexes in Tuscaloosa, Alabama, can generally be characterized as predominantly women with a low socioeconomic status living alone. A majority of the participants consumed less than the RDA for food energy. The protein intake was nearly equal to or exceeded the RDA; however, the mean intake of zinc was only half of the RDA. The mean hair zinc concentration of the participants corresponded with the levels reported for this age group by other researchers. Their mean taste thresholds were higher (lower taste acuity) than those reported for young adults. Detection thresholds decreased as the ages of the participants increased. The taste acuity of the participants resembled that of groups of elderly studied by other investigators. A precise definition of low zinc status measurements among the elderly is not available at this time. However, the low hair zinc concentrations and taste acuity, compounded with the low zinc intake, indicate that this population is at risk for zinc deficiency.

Aged↗
PubMed1980

Preschool vegetarian children. Dietary and anthropometric data.

Three-day dietary intakes were obtained on forty-eight preschool children between two and five years old, who had followed a vegetarian diet since birth. Intakes were calculated for food energy and selected nutrients. In addition, the children were measured for height, weight, triceps and subscapular skinfolds, and arm circumference. Average dietary intakes of the children compared favorably with the Recommended Dietary Allowances. Calcium was the only nutrient consumed in less than optimal amounts. Average intakes of the calculated amino acids were adequate when compared with available information. In general, anthropometric data were below the standards established by HANES findings, the National Center for Health Statistics, and available arm circumference data.

Anthropometry↗