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Biomedical subjects

C W Legerton

Publications and source records attributed to C W Legerton.

10 recordsLinked to original sources
PubMed1995

Systemic sclerosis (scleroderma). Clinical management of its major complications.

Systemic sclerosis (scleroderma) is a disease of unknown cause whose pathogenesis involves interaction between the vasculature, the immune system, and connective tissue cells. Although specific therapy awaits a better understanding of its pathogenesis, proper management may enhance not only the duration, but the quality of life for most scleroderma patients. Presently, controlled prospective trials of therapeutic agents are lacking. Published reports of drug therapy for skin, kidney, cardiac, pulmonary, and gastrointestinal complications, as well as management of Raynaud's phenomenon, are critically reviewed in this article, and the authors' approach to management of difficult clinical problems is presented.

Gastrointestinal Diseases↗
PubMed1993

Rheumatoid arthritis.

Explore the source record for details and available documents.

Anti-Inflammatory Agents↗
PubMed1984

Duodenal and gastric ulcer healing rates: a review.

The H2-receptor antagonists ranitidine and cimetidine are more effective than placebo in healing duodenal and gastric ulcers. However, the results of many studies suggest that a significant number of patients respond to treatment with placebo. In general, gastric ulcers respond somewhat more slowly to H2-receptor antagonists than do duodenal ulcers. Comparison trials between ranitidine and cimetidine indicate that both agents are equally effective in healing duodenal ulcers. With gastric ulcers, the results are variable, and neither agent is as effective as in the treatment of duodenal ulcer.

Cimetidine↗