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Biomedical subjects

C W Lewis

Publications and source records attributed to C W Lewis.

At least 19 recordsLinked to original sources
PubMed1992

Cytotoxic fungal spores in the indoor atmosphere of the damp domestic environment.

Eight-three fungal isolates collected and cultured from the air spora of damp public sector Scottish housing have been screened for cytotoxic properties. A bioassay procedure has been utilised for this purpose involving cytotoxic effects on human embryonic diploid fibroblast lung cells grown as monolayer cultures within the wells of microtitre plates. The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] biochemical assay system employed has revealed that 39 (47%) of the moulds investigated possessed spore-associated cytotoxic properties; a value which emphasises the potential health hazards of the continual inhalation of toxigenic fungal propagules by occupants of mouldy houses. Penicillia, the most prevalent fungi found in the internal atmosphere of the domestic environment, accounted for the great majority of cytotoxic strains identified.

Air Microbiology↗
PubMed1991

Sources of air pollutants indoors: VOC and fine particulate species.

The average concentrations of a large number of fine particle aerosol and VOC species measured in ten Boise, Idaho, residences in wintertime have been apportioned according to their contributions from all inside sources and all outside sources, regarded as two composite source categories. Air change rates for the residences were in the range 0.2-0.8 hr-1. None of the residences had obvious major indoor sources (smokers, woodburning appliances, etc.). The two category apportionment was accomplished through use of the single chamber mass balance indoor air quality model given by Dockery and Spengler. The method depends on the availability of average concentrations measured outside each residence during the same sampling periods used for the inside measurements, and on the ability to identify one or more species that have negligible indoor sources. Calculated infiltration factors (the indoor/outdoor ratio in the absence of indoor sources) for fine particle species averaged 0.5, and varied in a reasonably way with measured air change rates, essentially independent of species. Infiltration factors for the VOCs were indistinguishable from unity. The relative importance of indoor and outdoor sources to measured indoor concentrations showed great variation between species and between residences. In most homes the indoor source contribution was dominant for fine particle Si, Ca, and Fe, while the infiltration contribution was dominant for S, K, Pb, Zn, mass, and extractable organic matter. Indoor contributions to individual VOCs were frequently very large at a few residences and negligible at the others.

Aerosols↗
PubMed1979

Carcinoma of the bladder treated by segmental resection.

We herein review 45 patients with carcinoma of the bladder treated by segmental resection from 1955 to 1976. Survival rates were similar to those reported in other series and compared favorably to those found with total cystectomy. Patients with high grade (III and IV) stage A tumors experienced a 100% recurrence rate and only 40% survived more than 5 years, whereas patients with low grade (I and II) stage A tumors had a 28% recurrence rate and 86% lived 5 years or more. Therefore, it is postulated that patients with high grade lesions, even though stage A, undergo more aggressive therapy. It also was found that extensive segmental resection, even though necessitating ureteroneocystostomy, resulted in a favorable 5-year survival rate.

Florida↗
PubMed1978

Symmetrical lividity of the palms and soles.

Symmetrical lividity (SL) was the term coined by Pernet in 1925 for symmetrical, bluish-red plaques on the soles of the feet, accompanied by hyperhidrosis and not corresponding to areas of pressure or patterns of innervation. We report two patients with a persistent eruption of the palms analogous to that described by Pernet on the feet. Unlike most reported cases of SL, our patients did not respond to topical drying treatments, but one patient partially responded to tretinoin. There appear to be two forms of SL: transient, which responds to drying; and persistent which does not respond to drying. The hyperhidrosis studied in one of our two patients was significantly greater within the plaques of SL than the normal palm. While we could suppress the hyperhidrosis with topical therapy, this failed to clear his hyperkeratosis or eliminate the livid color.

Adult↗
PubMed1978

Correlation of infrared spectroscopy with platelet morphology in blood compatibility studies of polydimethylsiloxane membranes.

Oxygenator membranes, polydimethylsiloxane elastomer, exposed to flowing heparinized canine blood in a perfusion system have been studied with respect to the platelet activation and the morphology of the membranes. Utilizing Fourier transform infrared spectroscopy couple with attenuated total reflection technique (ATR) and laser Raman spectroscopy, no obvious differences in morphology and composition of the membranes have been detected while electron microscopic study shows difference in platelet aggregation.

Animals↗
PubMed1978

Skin lesions in paroxysmal nocturnal hemoglobinuria.

Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon hemolytic anemia that rarely manifests skin lesions. Leg ulcers and purpura similar to the manifestation of thrombotic thrombocytopenic purpura (TTP); disseminated intravascular coagulation, and Henoch-Schönlein purpura do occur. This is the second known case report of PNH with histopathologic features of TTP. Clinically, our patient's condition resembled TTP with disseminated intravascular platelet aggregation, and she followed a nonfulminant course. She improved on a regimen of systemic steroids, dipyridamole, and cessation of antibiotics.

Adult↗
PubMed1978

Contact dermatitis to homomenthyl salicylate.

Two patients with follicular dermatitis were found to have a contact sensitivity to homomenthyl salicylate, a sunscreening chemical present in a commercially available suntan lotion. One patient did not use the product, but her boyfriend did, and contact between the two individuals resulted in a follicular dermatitis developing in her. A second patient with contact dermatitis to homomenthyl salicylate also had a follicular eruption. Both patients appear to represent true allergic sensitivities.

Adult↗
PubMed1978

Invisible dermatoses.

An invisible dermatosis is defined as a skin disease manifesting no clinically apparent lesion but histologic changes of a characteristic nature. An example of an invisible form of transient acantholytic dermatosis is presented. Invisible forms of pseudoxanthoma elasticum, sarcoidosis, lepromatous leprosy, and lichen planus are reviewed. Dermal deposits may also be found on biopsy of clinically normal skin in amyloidosis, Hunter's and Hurler's syndromes, and thyroid disease.

Acantholysis↗
PubMed1977

Candidiasis seminar.

This is a review of candidiasis from its historical, epidemiologic aspect through the laboratory diagnoses, precipitating factors and the more common diseases caused by Candida. Therapeutic modalities available are listed and specific guidelines for therapy are demonstrated.

Adult↗
PubMed1976

Hereditary hemorrhagic telangiectasia with cerebrovascular malformations.

Three cases of hereditary hemorrhagic telanglectasia (HHT) with cerebrovascular malformation are presented. Previous reports of HHT have given little attention to its association with cerebrovascular malformation, despite frequent neurological symptoms in patients with HHT. Eleven other cases of HHT with neuropathologic or radiographic evidence of cerebrovascular malformation have been reported in the literature. We think that this association may be more frequent than previously suspected. The subtlety of the symptoms in HHT is stressed, and it is suggested that patients with cerebrovascular malformation be examined carefully for HHT, and vice versa.

Adult↗