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Biomedical subjects

C W Nichols

Publications and source records attributed to C W Nichols.

At least 19 recordsLinked to original sources
PubMed1991

Orbital ischemia, ophthalmoparesis, and carotid dissection.

We report a patient who developed an acute loss of vision in the left eye associated with proptosis, ophthalmoparesis, conjunctival injection, and chemosis. Funduscopy revealed optic disc swelling, and retinal whitening consistent with an ophthalmic artery occlusion. Angiography disclosed bilateral carotid dissections presumably resulting from head trauma 11 days earlier. An orbital ischemic syndrome may be a delayed manifestation of traumatic carotid dissection and precede cerebral hypoperfusion.

Aortic Dissection↗
PubMed1990

Rhinocerebral mucormycosis: management and survival after carotid occlusion.

Rhinocerebral mucormycosis is a rare but often fatal fungal infection. We present 2 patients with mucormycosis complicated by internal carotid artery thrombosis. Magnetic resonance imaging was superior to computed tomography in localizing the pathological process. Subtotal resection of devitalized tissue and intravenous amphotericin B therapy resulted in a successful outcome for both patients. Prompt recognition of this disorder by using modern diagnostic and therapeutic modalities promises to improve survival rates.

Adult↗
PubMed1990

Conjugal temporal arteritis.

We report the simultaneous occurrence of biopsy-proven temporal arteritis in husband and wife. Serologic and viral studies were negative, including viral culture of the wife's temporal artery. The concurrent incidence of giant cell arteritis in a married couple would suggest a common exogenous exposure.

Aged↗
PubMed1988

Bilateral ocular disease as the initial presentation of malignant lymphoma.

Malignant lymphocytic lymphoma rarely involves the eye. In two patients we found ocular signs and symptoms as the initial presentation of systemic disease. In the first patient periorbital swelling and ptosis of one year's duration ultimately proved to be the result of malignant lymphoma. After resolution of swelling and ptosis with chemotherapy, the patient returned with diffuse iris involvement and uveitis with a hypopyon. In the second patient an acute change of refractive error proved to be the result of a lymphomatous deposit in the choroid. In both instances common symptoms were the initial manifestations of a diffuse malignant disease.

Choroid Neoplasms↗
PubMed1985

Intralesional triamcinolone for cutaneous palpebral sarcoidosis.

Cosmetically disfiguring bilateral palpebral sarcoid dermatitis in a 32-year-old woman was treated with intradermal triamcinolone. There was rapid and complete resolution of lesions and there was no evidence of recurrence or hypopigmentation at a one-year follow-up examination. Thus, intradermal corticosteroid therapy can be useful for skin lesions in patients with sarcoidosis who do not require systemic therapy.

Adult↗
PubMed1979

Evaluation of the toxicologic and teratogenic potentials of sodium fluorescein in the rat.

Sodium fluorescein (10%) when injected intravenously (5 ml/kg) in pregnant albino rats crossed the placental barrier and appeared to be distributed throughout the fetus within 15 min. It was detectable in the fetus up to 4 h after injection but not beyond 24 h. A single intravenous administration of sodium fluorescein did not produce embryotoxic or teratogenic effects. Oral LD50 studies using sodium phenobarbital on rats which received sodium fluorescein during their fetal development showed no apparent effects of sodium fluorescein on their drug detoxification systems.

Abnormalities, Drug-Induced↗
PubMed1979

Unusual presentation of ocular toxocariasis in friends.

Two cases of presumed ocular toxocariasis are reported in 19-year-old college students. One presented with an acute exudative intraocular inflammation, with marked peripheral eosinophilia, while the other had only minimal inflammatory changes of the disc and vitreous. Both had elevated Toxocara antibody titers by the enzyme-linked immunosorbent assay (ELISA) method. The simultaneous occurrence of ocular toxocariasis in friends and the early presentation and detection of their ocular lesions make these 2 cases interesting. The presence of positive laboratory data with only minimal clinical disease in one of the cases suggests that ocular toxocariasis may be more common than is usually appreciated.

Adult↗
PubMed1979

Retinal arteriolar changes as an indicator of coronary artery disease.

Funduscopic examination was performed in 70 non diabetic, nonhypertensive patients without valvular heart disease undergoing coronary angiography for evaluation of chest pain syndromes to determine if retinal arteriolar changes could reliably predict presence of coronary artery disease. Retinal arteriolar changes were graded with respect to light reflex, vessel caliber, arteriovenous crossing defects, and vessel tortuosity without knowledge of angiographic findings. Each coronary vessel was graded with respect to its most occlusive lesion by angiography; coronary index was derived for each patient without knowledge of eye findings. Abnormal light reflex changes were the most sensitive indicators of presence and extent of coronary artery disease. Abnormal vessel tortuosity and decreased caliber were less sensitive but more specific; their presence also suggested more extensive coronary lesions. Thus, funduscopic examination demonstrating specific retinal arteriolar lesions may indicate presence of coronary artery disease and may correlate with extent of lesions in selected patients.

Adult↗
PubMed1978

Tube carbohydrate assimilation method for the rapid indentification of clinically significant yeasts.

Yeasts have gained greater recognition in the past several years as being the cause of significant infections. We modified and evaluated a carbohydrate assimilation test to identify yeast isolates rapidly and accurately. The 192 clinical isolates used in this study included 20 species of the genera Candida, Cryptoccoccus, Saccharomyces, Torulopsis, Trichosporon, Rhodotorula, and Geotrichum. The method achieved 95% agreement with standard Wickerham assimilation results, and 97% of the isolates were correctly identified with the aid of a few auxilliary tests. The method is rapid, reliable, and versatile in its use.

Carbohydrate Metabolism↗
PubMed1978

Evaluation of a commercial multitest system for identification of yeasts.

A new commercial yeast identification system, the Randolph Multitest Mycology Plate, was evaluated. This system is based on the assimilation of carbohydrates, growth on birdseed agar, resistance to cycloheximide, hydrolysis of urea, and reduction of nitrate. The 184 clinical isolates used in the evaluation included 20 species of the genera Candida, Cryptococcus, Saccharomyces, Torulopsis, Trichosporon, Rhodotorula, and Geotrichum. Agreement with the standard Wickerham carbohydrate assimilation and other conventional biochemical results was found in 84 percent of the tests, and 91 percent of the yeasts were correctly identified with the aid of microscopy, cultural characteristics, and germ-tube formation. Identification of the tested strains was achieved within 96 hours.

Bacteriological Techniques↗
PubMed1978

Late hyphema due to vascularization of the cataract wound.

Nineteen patients with hyphema due to fibrovascular tissue in the cataract wound were seen. In 3 patients the hyphema occurred after closure of an unitentional filtering bleb. Two patients receiving anticoagulants before and after the hyphema occurred did not have recurrence of the bleeding. In one patient the hyphema was induced by scleral depression. This benign condition is frequently misdiagnosed. When erythrocytes are seen in the anterior chamber of an aphakic patient, vascularization of the cataract wound should be suspected and confirmed by gonioscopy.

Adult↗
PubMed1978

Presumed orbital sarcoidosis: report of a case followed by computerized axial tomography and conjunctival biopsy.

A thirty-two-year old woman with known sarcoidosis was seen in the Ophthalmology Clinic because of discomfort in the left eye and orbit when looking up. A CT scan showed a small mass in the posterior left orbit. Conjunctival biopsy of the left eye showed a granuloma consistent with sarcoid. Rapid resolution of her condition occurred with prednisone therapy. One year later she had a recurrence with inability to elevate or depress the left eye. Similar, but more extensive, changes were seen on a CT scan. Conjunctival biopsy again was positive. With steroid therapy rapid and complete resolution occurred both clinically and as demonstrated by a CT scan. The relationship between her orbital mass and systemic sarcoidosis is discussed.

Adult↗
PubMed1977

Malignant lymphoma of thenasopharyns in waldenström's macroglobulinemia: report of a case with severe epistaxis.

An elderly woman with Waldenström's macroglobulinemia of four years' duration developed repeated severe epistaxis. This led to the discovery of a large malignant lymphoma of the nasopharynx. The clinical features of this rare case are discussed in relation to our present understanding of WM. Epistaxis in macroglobulinemic patients may be associated with anatomic lesions of the nasopharynx.

Chlorambucil↗