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Biomedical subjects

C W Solt

Publications and source records attributed to C W Solt.

12 recordsLinked to original sources
PubMed1998

Clinical comparison of bioabsorbable barriers with non-resorbable barriers in guided tissue regeneration in the treatment of human intrabony defects.

The purpose of the study was to compare the effects of guided tissue regeneration (GTR) with expanded polytetrafluoroethylene (ePTFE) non-resorbable barriers and polylactic acid bioabsorbable barriers in humans with intrabony defects due to periodontitis. Ten patients presented with 2 intrabony defects each. Mucoperiosteal flaps were performed. One of the defects was randomly assigned for placement of the ePTFE barrier over the roots and alveolar bone and the other defect with placement of the polylactic acid barrier. A minimum of 9 months after barrier placement, surgical reentry was performed. The data were evaluated by the Wilcoxon matched-pairs signed-ranks test and the Fisher exact test. Treatment with both types of barriers produced significant changes from baseline for all parameters, except in the ePTFE group for the amount of bony crest resorption (P = 0.055) and in the polylactic acid group for increased recession (P = 0.109). The results showed no significant differences between the barriers for any parameters: probing depth reduction (polylactic acid 2.60 +/- 1.90, ePTFE 2.80 +/- 1.40; P = 1.000); attachment gain (polylactic acid 1.40 +/- 1.43, ePTFE 1.90 +/- 1.29; P = 0.336); increased recession (polylactic acid 0.80 +/- 1.40, ePTFE 1.10 +/- 0.99; P = 0.531); amount of vertical bone fill (polylactic acid 1.60 +/- 1.84, ePTFE 2.00 +/- 2.49; P = 0.984); bony crest resorption (polylactic acid -1.30 +/- 1.06, ePTFE -1.30 +/- 1.63; P = 1.000); depth of bony defect reduction (polylactic acid 2.90 +/- 1.20, ePTFE 3.30 +/- 1.70; P = 0.750); width of bony defect reduction (polylactic acid 2.20 +/- 1.23, ePTFE 2.20 +/- 1.23; P = 0.875); or volumetric changes (polylactic acid 33.50 +/- 19.70 microl, ePTFE 34.00 +/- 18.40 microl; P = 0.750).

Absorption↗
PubMed1993

Histologic evaluation of periodontal attachment apparatus following the insertion of a biodegradable copolymer barrier in humans.

The purpose of this study was to histologically evaluate the effectiveness of polylactide:polyglycolide 50:50 (DL-PLGA) as a barrier to prevent epithelial migration and to promote new connective tissue attachment. Mucoperiosteal flaps were performed on 17 human teeth. DL-PLGA membrane was placed over the roots and alveolar bone. DL-PLGA was not placed over control teeth. Ninety days following surgery, block sections were obtained and processed for histologic evaluation. All specimens revealed a mean length of epithelial attachment within physiologic limits and recession of the gingival margin. There was little or no reattachment of the connective tissue. It is concluded that this copolymer barrier did not prevent epithelial migration nor enhance connective tissue attachment to human roots with severe horizontal bone loss and active periodontal disease.

Adult↗
PubMed1991

Association of cellular thiol redox status with mitogen-induced calcium mobilization and cell cycle progression in human fibroblasts.

Human gingival fibroblast cultures were used to investigate the role of cellular thiol redox status in the mitogenic response. Increases in intracellular Ca2+ and cell cycle progression beyond G1 were followed as parameters of cellular mitogen-induced responses. Ethionine provided a G1 stage synchronization and altered the cellular redox poise as measured by the ratio NAD(P)H/NAD(P)+. Cultures harvested immediately after the 6 day ethionine low-serum synchronization showed a significant oxidation of their redox poise. Synchronized cultures, which were also glutathione (GSH) depleted, still showed an oxidized redox poise and significantly reduced GSH levels following a 24 hr incubation in drug-free, rich medium. Cellular reduced nicotinamide nucleotide levels correlated strongly (r = 0.995) with capacity to mobilize intracellular Ca2+ in response to basic fibroblast growth factor (bFGF). The sustained mitogenic response, as determined by cell cycle progression beyond G1, was also found to be interrelated with the cellular thiol redox status. Following a 24 hr recovery incubation in serum-rich medium, formerly synchronized cultures showed a rebound of their redox poise to a more reduced state and significant cell cycle progression beyond G1. In contrast, synchronized, GSH-depleted cultures did not progress and showed population distributions similar to those of cultures harvested immediately postsynchronization. Upon recovery of cellular GSH and reduced nicotinamide nucleotide levels, formerly GSH-depleted, growth-arrested cultures resumed cell cycle progression. The results suggest that the cellular response to specific mitogens is interrelated with the cellular thiol redox status. Cells that possess a thiol redox status below a threshold response point may have compromised Ca2+ sequestration and/or mobilization and therefore may be incapable of initiating the mitogen induced response cascade that culminates in cell cycle progression.

Calcium↗
PubMed1990

The histologic evaluation of new attachment in periodontally diseased human roots treated with tetracycline-hydrochloride and fibronectin.

The purpose of this study was to determine how the treatment of human tooth roots with tetracycline-HCl and fibronectin during periodontal surgery influences the attachment of the gingiva to the root surface. Mucoperiosteal flap surgery was performed on 22 teeth with periodontal disease. Teeth were assigned to three groups. Group one received surgery with degranulation and root planing. Group two received surgery with treatment of roots with tetracycline-HCl. Group three received surgery with treatment of roots with tetracycline-HCl and fibronectin. At 90 days, block sections were taken and teeth, gingiva, alveolar bone, and periodontal ligament were evaluated histologically. Controls healed with a long junctional epithelial attachment. Tetracycline and tetracycline with fibronectin groups demonstrated some reattachment, but only within the notches placed in the root at the original level of the bone. There was a trend for greater connective tissue attachment following tetracycline-HCl treatment of roots. The additional application of fibronectin to tetracycline treated roots appeared to partially negate the enhanced connective tissue attachment observed with tetracycline treatment alone.

Acid Etching, Dental↗
PubMed1988

An evaluation of new attachment formation using a microfibrillar collagen barrier.

The objective of this study was to evaluate the effectiveness of microfibrillar collagen as a barrier to prevent epithelial migration and allow for guided tissue regeneration. Fourteen study teeth were selected. Mucoperiosteal flaps were elevated and roots were debrided and planed. Avitene was placed over teeth and alveolar bone. Flaps were then sutured over it. At control sites no Avitene was placed. At 90 days, block sections were obtained and processed for histologic and histometric evaluation. Results revealed that all specimens had a long junctional epithelial attachment. New attachment was present within the area of the root notch at the original level of the alveolar bone, and there was no significant difference in mean connective tissue attachment between the control and experimental specimens (P = 0.614). Avitene did not form an effective barrier to epithelial migration nor did it allow for guided tissue regeneration and significant new attachment formation in humans.

Alveolar Process↗
PubMed1984

The effects of various levels of ascorbic acid intake upon growth and organ weights of guinea pigs.

The purpose of this study was to evaluate the systemic effects of varying levels of orally administered ascorbic acid during wound healing in guinea pig oral mucosa. Forty five Murphy/Hartley guinea pigs were randomly placed into four groups and fed an ascorbic acid deficient diet for 2 weeks. Each group of animals then received a daily oral supplement of the following doses of ascorbic acid: 0.5 mg, 5.0 mg, 50 mg, and 250 mg. All animals were weighed twice a week. Twenty eight days later, a standardized wound was made in the premaxilla. On day 35, all animals were sacrificed. Blood samples were evaluated for levels of ascorbic acid. Thirty nine samples showed insignificant levels of vitamin C, 32 of which showed no ascorbic acid. Organ to body weight ratios were calculated and compared. Spleen to body weight ratios were not affected by different ascorbic acid levels. High levels of ascorbic acid caused a significant increase in adrenal gland to body weight ratios. Varying the levels of ascorbic acid did not affect growth prior to surgical wounding. Increased levels of ascorbic acid enhanced body weight recovery post surgically.

Adrenal Glands↗
PubMed1980

A surgical procedure for the treatment of localized gingival recession in conjunction with root surface citric acid conditioning.

A total of 9 teeth were treated with a free gingival graft followed by a coronally positioned flap in conjunction with conditioning of the root surface with citric acid. The grafting procedure was done 2 weeks after the subjects could perform adequate plaque control. Thirty days after grafting, a mucoperiosteal flap was raised. The root surface was thoroughly planed and conditioned with citric acid at pH 1.0, and the flap was then positioned coronally. Clinical measurements of the amount of recession, sulcus depth, and keratinized gingiva were taken preoperatively, and at 30 and 60 days after surgery. Recession was reduced by a mean of 3.24 +/- 2.08 mm. Width of keratinized gingiva was increased to a mean of 4.99 +/- 1.23 mm. Both of these findings were highly significant. Sulcus depth was not significantly changed.

Acid Etching, Dental↗
PubMed1977

Elastic response of the temporo-mandibular joint to very small forces.

The mechanical mobility of the temporo-mandibular joint (TMJ) was measured by applying small sinusoidal forces at different frequencies to the teeth and measuring the resultant motion of the teeth. Velocity/force ratios were recorded versus frequency at maxillary and mandibular teeth and the results were interpreted in terms of linear spring-mass-dashpot models. Differences in results obtained at maxillary and mandibular teeth indicate that the TMJ has an effective spring constant of 9 X 10(7) dynes/cm when excited by forces of approximately 2 X 10(3) dynes. Displacements occurring in the TMJ due to orthodontic elastics will be in the order of 20 mum which is between one and two orders of magnitude smaller than could be detected by radiography.

Adult↗
PubMedDate not supplied

Surgical techniques for covering exposed roots.

Each grafting technique described here produced successful root coverage. Predictable root coverage by use of current techniques has increased options for managing gingival recession and associated problems.

Adult↗