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Biomedical subjects

C Waggenspack

Publications and source records attributed to C Waggenspack.

8 recordsLinked to original sources
PubMed1979

Influence of dose and fiber type on respiratory malignancy risk in asbestos cement manufacturing.

This investigation provides information concerning the risk or respiratory malignancy in relation to duration, degree, and fiber type of exposure to asbestos in a manufacturing cohort of 5,645 with long-term follow-up. Excess mortality for this cause was found in groups with moderate and high cumulative exposure (standard mortality ratios of 290 and 226). Analysis of the influence of components of total exposure dose (duration, average concentration) revealed no detectable excess risk in persons employed for less than 2 years or with low-degree average exposure. Exposure to corcidolite (blue) fiber in addition to the predominantly used chrysotile in pipe making appeared to be associated with higher risk than was exposure to chrysotile alone.

Aged↗
PubMed1975

Lung function consequences of dust exposure in asbestos cement manufacturing plants.

A comprehensive study of health effects associated with the mixed dust exposure in this industry has included the collection of clinical, radiographic, lung function, and dust exposure data on 859 workers in two plants. Evidence is presented supporting a dose-response relationship between indexes of dust exposure and lung function, similar to the previously reported relationship with extent of x-ray film changes using the ILO U/C classification. Lung volumes and maximum expiratory flow rates decrease in relation to increasing cumulative dust exposure while pulmonary diffusing capacity (DL) is not dust-dose related. Worders who had crocidolite exposure had smaller lung volumes, lower expiratory flow rates, and reduced DL when compared with those having only chrysotile exposure. When the study population is divided into exposure groups, data thus far analyzed suggest that the chest x-ray film will reveal small opacities as early as significant functional changes can be detected, but individuals may have functional reduction prior to the appearance of x-ray film changes.

Adult↗
PubMed1975

Differences in lung effects resulting from chrysotile and crocidolite exposure.

Crocidolite asbestos exposure may carry a greater risk for the development of lung and pleural tumours than chrysotile exposure, although differences in regard to lung fibrosis have not previously been demonstrated. Clinical, radiographic and physiological indicators of lung disease were related to qualitative and quantitative estimates of past total dust exposure in two groups of workers who had spent 20 to 30 years in the asbestos cement industry. One group had exposure to chrysotile, silica and crocidolite in the pipe-making area; the other group had no crocidolite exposure. Crocidolite exposure was related to the prevalence of small irregular opacities and pleural thickening but not to small rounded opacities. The "crocidolite" group had significantly small lung volumes, lower forced expiratory flows, and reduced pulmonary diffusion. Finger clubbing was the only clinical fineing significantly more prevalent in the crocidolite-exposed workers. It is suggested that crocidolite exposure has a greater fibrogenic effect on the lungs than a similar total exposure to chrysotile asbestos.

Asbestosis↗