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Biomedical subjects

C Wasi

Publications and source records attributed to C Wasi.

At least 109 records · Page 6Linked to original sources
PubMed1985

Rubella outbreak in Thailand 1983-1984: a study at Siriraj Hospital.

The recent rubella epidemic in Thailand prevailed from September 1983 to August 1984 with its peak in March. Throughout the outbreak, approximately 70% of the cases diagnosed clinical rubella were laboratory proved. In the middle of the outbreak, accuracy of the clinical diagnosis was 75-87%, while it was 25-33% at the beginning and the end. Concerning the clinical findings in rubella, maculopapular rash may be generalized or localized, and lymphadenopathy occurred only in 40% of the clinical cases. Lymphadenopathy and respiratory symptoms appeared 3 times more frequent than those in the non-rubella cases. Rubella inapparent infection occurred in 5.14% of the contact cases. Acquisition of the disease after contact did not depend on the degree of close relationship between the index cases and the contact cases. Outcome of pregnancy and congenital rubella infection after the outbreak have to be further investigated.

Disease Outbreaks↗
PubMed1984

Use of post-exposure intradermal rabies vaccination in a rural mission hospital.

The efficacy of single site, intradermal human diploid cell rabies vaccine (HDCV) was assessed in patients exposed to rabies, who were treated at a rural mission hospital in central Thailand. Intradermal HDCV, 0.1 ml on days 0, 3, 7 and 14, resulted in protective antibody levels by day 14, with measurable titres present at one year. 98% of 219 patients completed primary vaccination and 84% returned for a one-year booster. No case of rabies has been seen in those vaccinated. Intradermal HDCV in small doses has given results superior to those from vaccination with nervous tissue vaccine with conventional schedules. This intradermal HDCV regimen has proved acceptable to patients, and is suitable for post-rabies-exposure care in developing countries where low cost is essential.

Adolescent↗
PubMed1984

Detection of varicella-zoster antibody by immune adherence hemagglutination test.

The immune adherence hemagglutination (IAHA) is a more sensitive and specific test for evaluation of humoral immunity to varicella-zoster virus (VZV) than a conventional complement fixation (CF) test. The equipment, reagents, procedure used in the IAHA are basically the same as those employed in the CF test. After VZ vaccination, seroconversions detected by IAHA test were significantly greater than those by CF test (P less than 0.01, chi 2 test). Moreover, the IAHA titers were higher about 4 times (G.M. 30.9 vs 8.2) and persisted longer than CF titers. Although the IAHA antigen is not a commercial product, the IAHA is sensitive and suitable assay for VZ antibody determination in routine serological laboratory.

Adolescent↗
PubMed1984

Rotavirus in pediatric diarrhoea at Siriraj Hospital, Bangkok, Thailand.

Between June 1982 and May 1983, rotavirus was found in 29% of 248 pediatric patients between 1 month to 5 years of age at Siriraj Hospital, Bangkok, Thailand. Among 413 household contacts, RV was detected in 9 (2%) of whom 6 developed diarrhoea. RV was not found in age-matched healthy controls. In a serological study, the serological response was 81% in rotavirus diarrhoea cases (17 out of 21) by ELISA. By the ELISA blocking test, the seroconversion rate was only 29.6% in rotavirus diarrhoea cases (8 out of 27) and in others, 2 out of 71 cases (2.6%) who also showed serological response did not have rotavirus in their stools. This study indicates role of rotavirus in causing acute diarrhoea in young children, suggests a guideline for diagnosis and management of the patients. The rotavirus immunization should be considered if the vaccine becomes available in the near future.

Acute Disease↗
PubMed1984

The effect of interferon on flaviviruses in vitro: a preliminary study.

The preliminary results of our study in vitro on the effect of Interferon on Flaviviruses showed that Interferon alpha and Interferon beta were more effective on JE viruses Vip local strain and JaGAr strain, but less on Dengue virus type 2 strain. However, the effect of these 2 interferons on the 2 strains of JE viruses were still variable which need further investigations. The JE virus Vip local strain seemed to be more susceptible to interferon than the Japanese prototype JaGAr strain. Thus, the in vivo trial on JE disease in Thailand is strongly recommended.

Dengue↗
PubMed1984

The effect of interferon on Japanese encephalitis virus in vitro.

The studies on the effect of the Recombinant Leukocyte A Interferon (r IFN-alpha A) on 4 local strains of JE virus in Thailand were performed in vitro in our laboratories in Bangkok during August - October 1984. The procedures consisted of the plaque reduction assay and the Rhesus monkey kidney cell line, LLC-MK2 cells. These 4 strains namely Vip, KE-093, KE-094 and KE-095 were isolated from the JE patients in Thailand during 1983-1984. The results revealed that all of the JE virus strains tested were sensitive to the r IFN-alpha A with its minimal effective doses ranging from 30 I.U./ml to 1,500 I.U./ml. The studies on the effects of r IFN-alpha A on JE virus replicating in the cell culture for 0 hour, 1 hour and 6 hours indicated that if the virus had more hours to replicate in the cell culture, higher concentration of the IFN was needed in order to combat the replication of the virus in the cell culture. r IFN-alpha A at higher concentrations showed more efficacy in combating the replication of the JE virus in vitro.

Animals↗
PubMed1983

Immunopathology of acute rheumatic fever and rheumatic heart disease. The demonstration of Coxsackie group B viral antigen in the myocardium.

Immunopathologic studies were performed on heart tissue of patients with acute rheumatic fever with carditis and chronic rheumatic heart disease. Coxsackie group B viral antigen was demonstrated in 3 heart specimens of patients clinically compatible with active rheumatic fever. In two of these the pathologic findings were compatible with acute rheumatic carditis. Immunoglobulin was detected in 2 and complement in one of these heart specimens. All of the chronic rheumatic heart specimens and the controls were negative. These findings suggested that Coxsackie group B virus may be etiologically related to the pathogenesis of acute rheumatic fever.

Acute Disease↗