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Biomedical subjects

C Watkins

Publications and source records attributed to C Watkins.

At least 19 recordsLinked to original sources

Epidemiology of nondental oral disease in the elderly.

This article presents the descriptive epidemiology, risk factors, and clinical highlights of the oral mucosal lesions that are most common or of greatest concern among the elderly. Leukoplakia, oral cancer, candidiasis, lichen planus, and RAU have not been studied extensively among the elderly. Recent efforts to standardize definitions and research methods should greatly enhance future information. The paucity of research on oral lesions such as herpes zoster, epulis, and oral medication reactions is surprising, given that these are common problems among the elderly.

Aged

How sick the baby?

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Acute Disease

IS1-dependent generation of high-copy-number replicons from bacteriophage P1 Ap Cm as a mechanism of gene amplification.

Mutant P1 Ap Cm lysogens were isolated in which the drug resistance genes resident on the plasmid prophage P1 Ap Cm are amplified by a novel mechanism. The first step required for amplification is IS1-mediated rearrangement of the P1 Ap Cm prophage. The drug resistance genes are amplified from the rearranged P1 Ap Cm prophage by the formation of a plasmid (P1dR) which contains the two resistance genes. The P1dR plasmid is an independent replicon about one-half the size of P1 Ap Cm that can be maintained at a copy number eightfold higher than that at which P1 Ap Cm can be maintained. It contains no previously identified replication origin and is dependent on the Rec+ function of the host.

Bacterial Proteins

Clinical assessment of azapropazone in rheumatoid arthritis.

Azapropazone was investigated in a 2-week double-blind clinical out-patient trial against placebo in 23 patients with definite rheumatoid arthritis. The drug was given at a dose of 1200 mg. per day before food. At this dose level the drug was shown to have an antirheumatic effect in terms of pain relief, articular tenderness and duration of morning stiffness.

Administration, Oral

Circulation policies in health science libraries.

There is general agreement that library policies have considerable influence on the use of libraries. Medical school (health science) libraries of this country were surveyed as to their policies in respect to whether faculty and student use were regulated by a single policy, circulation regulations, hours library was accessible to users, accessibility of reserve material, interlibrary loan, policy on overdue material, and exit control. THE LIBRARIES WERE THEN DIVIDED INTO THREE GROUPS, HIGH, MIDDLE, AND LOW ACCORDING TO THE FOLLOWING CHARACTERISTICS: size of student body, size of faculty, size of holdings, size of library staff, annual budget, and annual circulation. Our findings would indicate that schools falling in a high category based upon these criteria tend to be more restrictive in their policies and to have different regulations for faculty and students than do schools in the low category.These findings warrant further study.

Libraries, Medical