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Biomedical subjects

C Weatherley

Publications and source records attributed to C Weatherley.

6 recordsLinked to original sources
PubMed1998

Painful scoliosis secondary to osteoblastoma of the vertebral body.

A 19-year-old boy with a painful thoracolumbar scoliosis was found to have an osteoblastoma of the body of T12. Excision of the tumour was carried out through a left thoracotomy approach and strut bone grafting was performed. Complete excision of the tumour was facilitated by intraoperative radiographs of the removed vertebra. Following surgery the patient's pain resolved completely and the deformity was partially corrected. Osteoblastoma of the vertebral body in the thoracolumbar region has not previously been reported. Diagnosis may be difficult unless the significance of the association between pain and the scoliosis is appreciated. The tumour is often not readily apparent on plain radiographs. Therefore, further radiological investigation in the form of a bone and CT scan is necessary to establish the diagnosis. Early excision of the tumour is essential to prevent a permanent structural scoliosis from developing.

Adult↗
PubMed1995

Combined anterior and posterior resection and spinal stabilization for aneurysmal bone cyst.

We report on a 19-year-old man with a 6-month history of pain and stiffness in the upper cervical region who proved to have a lytic lesion affecting the anterior and posterior elements of C2-4, causing a severe gibbous deformity at C3. The tumour was excised through a posterior approach, and spinal fusion with instrumentation was performed. Two weeks later, through a right-sided, anteromedial approach, the remaining tumour was excised, and the spine was reconstructed with tricortical iliac bone as a strut graft. The patient was placed in a Minerva jacket for 3 months, during which time a solid fusion was obtained. The histological diagnosis was aneurysmal bone cyst. The patient has remained pain free and suffered no recurrence 2 and a half years after surgery. Involvement of several adjacent cervical vertebrae by an aneurysmal bone cyst is rare, and conventional treatment with curettage and bone grafting is most likely to carry a high rate of recurrence and spinal instability. We recommend complete excision of the tumour in a combined staged procedure and instrumentation to prevent recurrence and avoid instability.

Adult↗
PubMed1984

Multiple Subunit Composition of Chloroplastic Glutamine Synthetase of Nicotiana tabacum L.

Chloroplastic glutamine synthetase from tobacco leaves (Nicotiana tabacum L. var Xanthi) was purified to homogeneity. By using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and high performance liquid chromatography, a single subunit was identified with a molecular weight of 45,000 daltons. However the native protein seems to be composed of four different subunits which can be separated by isoelectrofocusing. It is suggested that different genes with eventual posttranslational and/or posttranscriptional modifications may control the synthesis of the chloroplastic glutamine synthetase.

Journal Article↗