Alternative strategies for funding a general dentistry residency program.
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Capital Financing↗
Biomedical subjects
C Wiggins
Publications and source records attributed to C Wiggins.
Melanoma within a southwestern Hispanic population.
The New Mexico Melanoma Registry and New Mexico Tumor Registry identified 81 cases of melanoma involving the skin and mucous membranes of Hispanics. The clinical and pathologic characteristics of these tumors were compared with those observed in whites. The frequency of melanoma in Hispanics appears to be no more than a sixth of that observed in whites. Female patients were more prevalent within the Hispanic population. The median patient age at diagnosis was similar in Hispanics and whites. A much larger proportion of melanomas in Hispanics occurred on the palms, soles, and in subungual regions. Acral lentiginous melanomas were correspondingly more frequent among Hispanics, as was mucous membrane melanoma. Melanomas arising from the palms, soles, subungual regions, and mucous membranes tended to be advanced in stage, to occur in older individuals, and to metastasize. These cases explain the generally poorer prognosis for Hispanic patients compared with whites. The epidemiology of melanoma relevant to these findings is discussed.
Adolescent↗
Testicular cancer and employment in agriculture and oil and natural gas extraction.
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Adolescent↗
Melanoma among southwestern American Indians.
All forms of skin cancer are uncommon among southwestern American Indians. The estimated average annual incidence of melanoma is approximately 1 per hundred thousand population or less than one tenth of that currently reported for Anglos (non-Hispanic whites) residing in the same region. This study correlates the clinical and pathologic features of melanoma in 18 American Indian patients. A marked predilection for palms, soles, and subungual locations was displayed. Additionally, three patients presented with mucous membrane primaries and two with ocular melanomas. Advanced disease stage at diagnosis was common. The protective influence of natural pigmentation in skin cancer is discussed.
Abdomen↗
Differences in the response pattern of aged female rats to treatment with lergotrile mesylate.
Old female rats exhibiting either the constant vaginal estrous (CE) or the prolonged diestrous (PD) state were given lergotrile mesylate (LM). Treatment with 4.5 mg/kg daily significantly reduced prolactin (PRL) levels in both groups. The basal luteinizing hormone (LH) levels were not altered. In the CE group, LM treatment produced a single prolonged cycle, with the reemergence of the CE state. However, in the PD group, the rats exhibited several regular cycles during the treatment period. Several of these rats also showed evidence of having an LH surge during the reinduced cycle. These results suggest that high PRL levels may be a causative factor with respect to acyclicity in the PD rats, but PRL does not seem to be a major contributor to acyclicity in the aged CE rat.
Aging↗
Differences in the stress response of prolactin in young and aged female rats.
The drawing of blood by orbital sinus puncture (OSP) under ether anesthesia is known to produce a marked increase in serum prolactin (PRL levels in young cycling female rats. The effect of this stressful procedure on PRL release was compared in young and aged female rats. Nonstressed PRL levels were obtained from blood drawn by decapitation. Whereas OSP with a one-minute ether exposure induced a marked increase in PRL levels in young rats on all days of the estrus cycle, older cycling female rats on the day of diestrus -1 and aged rats exhibiting prolonged diestrus (PD) showed virtually no increase above nonstressed levels. However, increasing the ether exposure time to five minutes did produce a rise in PRL levels. Old cycling female rats on the day of estrus and aged rats exhibiting constant estrus (CE) did show a PRL increase comparable to that seen in young animals. Ovariectomy (OVX) completely abolished the stress response seen in aged CE rats. The response, though markedly decreased, was still present in young ovariectomized rats. These experiments show that the stress-induced rise in PRL promoted by OSP under either anesthesia is markedly diminished in aged rats exhibiting a diestrus state. The attenuated response seen in these rats is believed due to factors characteristic of the diestrous state of aging.
Aging↗
Iontophoretic application of adenine arabinoside monophosphate for the treatment of herpes simplex virus type 2 skin infections in hairless mice.
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Animals↗
Effect of iontophoretic and topical application of antiviral agents in treatment of experimental HSV-1 keratitis in rabbits.
Cathodal (-) iontophoresis of 9-beta-D-arabinofuranosyl-adenine 5'-monophosphate (vidarabine monophosphate; Ara-AMP) was performed once daily for 3 days for the treatment of experimental herpes simplex virus type 1 (HSV-1) keratitis in rabbit eyes, and the therapeutic efficacy was compared with that of topical treatment of Ara-AMP and idoxuridine (IDU) administered five times daily for 4 days. With the treatment initiated 24 hr after viral inoculation, Ara-AMP cathodal iontophoresis resulted in significant suppression of epithelial and anterior segment disease processes. Topical IDU (0.5%) or Ara-AMP (10%) also significantly improved the disease process when compared to the placebo-treated group; however, iontophoresis of Ara-AMP resulted in a more marked improvement. Slit-lamp examination indicated that iontophoresis did not cause any observable pathologic changes in corneal epithelium, stroma, conjunctiva, or iris of rabbit eyes. This experiment suggests that iontophoresis of Ara-AMP is a safe and effective approach for preventing the development of herpes simplex keratitis in rabbits.
Administration, Topical↗
Absence of nasal priming as measured by rhinitis symptom scores of ragweed allergic patients during seasonal exposure to ragweed pollen.
A priming effect, increasing responsiveness of the nasal mucosa as measured by nasal patency or resistance, has been reported to occur after nasal challenge on successive days. Because it has been suggested that the priming effect may be of clinical importance, we have studied whether such an effect occurs during natural pollen exposure as measured by symptom-medication scores in 29 patients with ragweed rhinitis. By Wilcoxon's signed rank test, we compared the symptom-medication scores of patients during two 7-day periods, one early in the season and one later, in which the weekly pollen count was approximately 250 grains/m3; we also compared an early and late period during which the weekly pollen count was approximately 500 grains/m3. There were no statistically significant differences in scores between early and late seasonal periods at the same pollen count. We conclude that the priming effect is not a clinically significant phenomenon during natural pollen exposure in allergic rhinitis patients.
Humans↗