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Biomedical subjects

C Wilde

Publications and source records attributed to C Wilde.

23 records · Page 2Linked to original sources
PubMed1976

Characterization of an adenylate cyclase system sensitive to histamine H2-receptor excitation in cells from dog gastric mucosa.

A method of preparing viable cells from dog gastric mucosa is described. Cyclic AMP in these cells is elevated by histamine and 4-methyl histamine but 2-methyl histamine is only a weak agonist. The effects on cyclic AMP levels are inhibited competitively by metiamide and burimamide which give apparent KBvalues of 3.5x10-7 M and 2.3x10-6 M, respectively. These values are similar to those reported for other histamine H2-receptor systems. The H1-receptor antagonists, mepyramine and chlorpheniramine, have no inhibitory effect on the histamine induced elevation of cyclic AMP: promethazine inhibits the system but not by a competitive mechanism. It is concluded that the histamine stimulated adenylate cyclase system is probably located in the parietal cell component.

Adenylyl Cyclase Inhibitors↗
PubMed1975

Aerosol metallic paints: deliberate inhalation. A study of inhalation and or ingestion of copper and zinc particles.

The preliminary and limited study was made in an area where the metallic spray paints are used as an intoxicant by a significant percentage of the student-population. Laboratory tests show that individuals misusing these unique products are ingesting and/or inhaling large amounts of copper and zinc which are excreted in the urine and are possibly retained in body tissue. No previous reports have been found on this form of substance misuse, and apparently no studies have been conducted to determine the physiological effects of such an overload of heavy metals.

Administration, Intranasal↗
PubMedDate not supplied

Improvement in care: a collaborative approach to rehabilitation.

Examination of the patient experience within our unit, from pre dialysis through to establishment of dialysis in the community identified that the care was fragmented. To improve patient care, a change process was initiated. Four home care teams comprising three qualified nurses and one renal care assistant were established with each team responsible for a caseload of patients within a specified geographical location. To measure the impact on the patient, 100 questionnaires were circulated after twelve months. Results from 60 patients showed 76% of pre dialysis patients and 80% of dialysis patients were very satisfied with the change process. The main advantage of this change for the patient is that they are in a continuous supportive cycle for all their non-inpatient care throughout their replacement therapy. We conclude that patient focused care is essential and should be a transition catalyst in a change resistant environment.

Hemodialysis, Home↗
PubMedDate not supplied

Diabetic nephropathy--who cares?

Diabetic nephropathy has become the most common single cause of Established Renal Failure (ERF) in the United States of America (USA) and Europe. In the United Kingdom (UK) diabetic nephropathy is seen in 18% of new patients requiring dialysis. In the USA 7.3% of all adults and 17.8% of those over 65 years have diabetes mellitus. Furthermore diabetic nephropathy is the cause of ERF in up to 45% of patients on dialysis. Recently compiled data by the World Health Organisation (WHO) shows that approximately 150 million people worldwide have diabetes and predict that this number may well have doubled to 300 million by 2025. These figures are clearly daunting and renal units must prepare themselves for the rising number of patients with diabetes needing renal replacement therapy (RRT) in the future. Renal specialist nurses do not always have a major role to play in the prevention of diabetic nephropathy. Their remit must be to try and delay the progression to ERF and perhaps more importantly to concentrate their efforts on their ERF patient population with diabetes that have co-existing diabetes related pathologies. This article will attempt to discuss how renal nurses can best expand/extend their skills and knowledge to provide effective care for this patient group, and explore whether developing new and innovative roles or just new ways of working is the way forward.

Diabetic Nephropathies↗