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Biomedical subjects

C Wilken-Jensen

Publications and source records attributed to C Wilken-Jensen.

10 recordsLinked to original sources
PubMed1991

Malignant giant cell tumour of the uterus.

Two rare cases of malignant giant cell tumours of the uterus in pure heterologous form are presented. Light microscopy showed numerous osteoclast-like cells in a background of spindle cells. Immunohistochemistry demonstrated Vimentin, Actin, alpha-1-antitrypsin and LCA in the latter, and Vimentin, alpha-1-antitrypsin and LCA in the giant cells while tartrate resistant acid phosphatase reactivity was demonstrated in both mononuclear cells and giant cells. Electron microscopy did not reveal smooth muscle or epithelial differentiation. The findings suggest a common origin of malignant giant cell tumours and malignant fibrous histiocytomas.

Aged↗
PubMed1990

Endocrine, metabolic and cardiovascular responses to adrenaline after abdominal surgery.

Adrenaline-induced changes in heart rate, blood pressure, plasma adrenaline and noradrenaline, cortisol, glucagon, insulin, cAMP, glucose lactate, glycerol and beta-hydroxybutyrate were studied preoperatively and 4 and 24 h after skin incision in 8 patients undergoing elective cholecystectomy. Late postoperative responses of blood glucose, plasma cAMP, lactate and glycerol to adrenaline infusion were reduced, whereas other responses were unaffected. Blood glucose appearance and disappearance rate as assessed by [3H]3-glucose infusion was unchanged pre- and postoperatively. The increase in glucose appearance rate following adrenaline was similar pre- and postoperatively. These findings suggest that several beta-receptor-mediated responses to adrenaline are reduced after abdominal surgery.

Adult↗
PubMed1989

[Effect of posture on the diuretic treatment of decompensated cirrhosis and heart failure].

The diuretic effect of the supine position was evaluated in six patients with cirrhosis and ascites and six with congestive cardiac failure. All patients received 1 mg bumethanide intravenously and were randomly assigned to either bed rest in the supine position or normal daily activity in the upright position for the next six hours. The diuretic response was similar in patients with heart failure and cirrhosis, and was significantly greater in the supine than in the upright position: mean 1,133 v 626 ml/6 h (p less than 0.01). The natriuresis was similarly greater during recumbency: mean sodium 96 v 45 mmol (mEq)/6 h (p less than 0.01), and the excreted potassium in six hours was similar in both postures. The glomerular filtration rate was 100 and 66 ml/min (p less than 0.01) and the heart rate 76 and 83 beats/min (p less than 0.05) in the supine and upright positions, respectively. Plasma concentrations of noradrenaline, renin, and aldosterone rose significantly during the upright position. The results suggest that the attenuated response to intravenous bumethanide in the upright position and during normal daily activity may be due to the activation of several, homoeostatic mechanisms which may reduce the excretion of water and salt.

Adult↗
PubMed1989

Removing a retained placenta by oxytocin--a controlled study.

No increase in maternal plasma oxytocin concentration was detected after administration of 100 IU oxytocin into the umbilical veins of seven women immediately after delivery. The delivery of the placenta was accelerated after umbilical vein injection of 100 IU oxytocin in a placebo-controlled study of 40 women: 12 minutes (4 to 40) in the oxytocin group versus 40 minutes (29 to 40) in the placebo group (median and interquartile ranges), p less than 0.05.

Clinical Trials as Topic↗
PubMed1987

Adenosarcoma uteri.

Adenosarcoma of the uterus is a rare tumor of low-grade malignancy. It belongs to the family of mixed mesodermal (Müllerian) tumors. It is a biphasic tumor with benign epithelium and malignant stromal components. A case in a 76-year-old woman is presented.

Aged↗
PubMed1987

Effective perioperative prophylaxis with a single dose of cefotaxime in transurethral prostatectomy.

In a prospective, observer-blind study, the authors assessed the efficacy of cefotaxime (2 gm IV) as auxiliary therapy to the currently used antimicrobial prophylaxis in transurethral prostatectomy. Cefotaxime was administered to 48 patients. From these, 188 blood specimens were drawn and eight blood cultures from eight patients were positive. From an untreated control group of 50 patients 196 specimens were drawn. Thirty-one of these specimens (from 17 patients) were positive (P less than 0.05). This significant reduction was due mainly to fewer pathogen isolates (1 versus 16). The number of postoperative complications was reduced from 21 in 15 patients to 12 in 10 patients (P less than 0.05). It is concluded that a single IV dose of 2 gm of cefotaxime protects against the immediate perioperative complications.

Aged↗