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C Wimer

Publications and source records attributed to C Wimer.

8 recordsLinked to original sources
PubMed1994

Autoimmunity and avoidance learning in NXRF recombinant inbred strains.

Four recombinant inbred (RI) strains, generated from NZB and RF progenitors, were tested on a two-way shuttlebox and their sera were assayed for serological factors. The four RI strains differed with respect to number of null responses and escape time. The strain with the poorest performance displayed the greatest degree of autoimmunity. The avoidance measures were correlated against the autoimmune serological parameters for the four RI strains and the two progenitors. The number of avoidances was negatively correlated with anti-DNA antibody titer, while the number of null responses showed a positive association with immune complex level. Escape time had positive correlations with IgG, IgM-RF, and immune complexes. These findings are consistent with, and extend, our prior reports that avoidance learning is inversely related to the degree of autoimmunity.

Animals↗
PubMed1989

Multicenter trial of naloxone in Alzheimer's disease.

In a double-blind, placebo-controlled, crossover study of intravenously administered naloxone hydrochloride, 54 subjects with clinically ascertained Alzheimer's disease tested at three university centers showed no significant improvement in neuropsychological performance after 1-mg or 10-mg doses; 15 patients at 1 center were similarly unimproved after receiving 30 mg naloxone (single blind). Findings fail to support claims that naloxone monotherapy ameliorates cognitive impairments of Alzheimer's disease.

Adult↗
PubMed1989

Alzheimer's dementia: performance on parallel forms of the dementia assessment battery.

Fifty-four patients with Alzheimer's disease performed on the Dementia Assessment Battery that comprised of finger tapping, forward digit span, naming, verbal memory, visual memory, Token Test, digit cancellation, word-list generation, symbol-digit substitution, and copying geometric designs. Four forms of the battery were administered at weekly intervals. The equivalence of the forms, the relative difficulty of the tests, retest reliability, and factorial composition of the battery are presented. Performance improved with repetition. Impairments in visuo-spatial and verbal abilities were independent of each other. The fragility of the patients' working memory was identified as a main cause for their poor recall. The importance of "component analysis" in individual assessment is illustrated.

Aged↗
PubMed1985

Three sex dimorphisms in the granule cell layer of the hippocampus in house mice.

Inbred strains of mice differ in number of neurons in the dentate granule cell layer of hippocampus and in granule cell density. In a study of both sexes in 6 strains, females had significantly lower granule cell density than males of the same strain. Females of strains with high neuron numbers had significantly fewer granule cells than males of the same strain, while males and females of low neuron number strains did not differ from each other. Sizes of neuronal nuclei were examined in males and females of two strains. No significant strain difference was found, but females had significantly smaller nuclei. The results suggest that hippocampal function is associated with the differing adaptive roles of male and female house mice.

Animals↗
PubMed1983

An association between granule cell density in the dentate gyrus and two-way avoidance conditioning in the house mouse.

Mice with genetically associated variations in the number and density of granule cells in the dentate gyrus were tested for open-field activity, spatial maze learning, and two-way avoidance conditioning. The number of granule cells was not associated with any behavior measured. Only avoidance conditioning was related to granule cell density, which had a negative correlation with performance on the shuttle box task. This result was replicated in two genetically different stocks of mice. Density of the more caudal portion of the dentate was associated with early stages of avoidance learning, whereas the more rostral portion was associated with later stages. The results are discussed in relation to theories of functional dissociation within the hippocampus.

Animals↗