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Biomedical subjects

C Wise

Publications and source records attributed to C Wise.

12 recordsLinked to original sources
PubMed1987

Computer instruction as part of a course on analytic medicine for first-year students.

The Medical University of South Carolina integrated instruction in information science and computer technology into a required freshman-level course. Analytic and Community Medicine. The advantages of this placement in the curriculum are two-fold. First, the course provides an opportunity to integrate computer methodology with clinically relevant topics such as medical decision-making. This integration enhances the students' view of the computer as a useful tool that can aid the physician in the practice of medicine. Course organizers are convinced that the success of the first offering is attributable to this integration. Second, the instruction comes early in the medical education process and allows the concepts learned to be utilized throughout the students' medical school careers. The degree to which these concepts and methods are actually utilized by students will depend upon the degree of reinforcement of these ideas in the clinical years and residency. Thus, faculty members must act as role models who not only acknowledge the importance of mastering the use of computers in medicine but also manifest those skills.

Community Medicine↗
PubMed1985

Exacerbation of lymphomatoid papulosis during treatment with danazol.

A patient who experienced exacerbation of a previously diagnosed condition of lymphomatoid papulosis during infertility treatment with danazol is reported. The condition worsened over the first month of treatment with medication and resolved completely upon discontinuation of the medication.

Adult↗
PubMed1978

Intramembranous particles in erythrocyte, reticulocyte and erythroblastic leukemic cells of the rat: a model system for erythrocyte maturation.

The density and size distribution of intramembranous particles (IMP) were determined for cells of the erythroid series. The number and size of IMP were measured on both fracture faces of erythroblastic leukemia cells, phenylhydrazine-induced reticulocytes and mature erythrocytes. We found that the number of IMP adhering to the protoplasmic fracture face of the plasma membrane increased with increasing maturation, while the number of particles adhering to the external fracture face did not correlate with maturational stage. In general, the mean size of particles adhering to both fracture faces decreased with increasing maturation after the erythroblastic stage. We interpret these results to mean that the IMP seen are derived from more than one macromolecular species and that they are distributed asymmetrically in the plasma membrane.

Animals↗
PubMed1977

The accessory outer segment of rods and cones in the retina of the guppy, Poecilia reticulata P. (Teleostei). An electron microscopical study.

The ultrastructure of the accessory outer segment (AOS)--a cilium-like structure emanating from the inner segment and running alongside the outer segment of photoreceptors--is described. The AOS occurs in both rods and cones of Poecilia reticulata. Its ultrastructure, including the arrangement of microtubules, which originate from the ciliary stalk, is the same in rods and cones. The cone-AOS is connected with the outer segment by a thin plasmabridge, whereaa the rod-AOS lies embedded within the outer segment. The outer segment of the cone, in contrast to that of the rod, is separated from the pigment epithelium by a large extracellular space. An intimate contact, however, is secured by the AOS; its membrane is closely appositioned to the pigment epithelium membrane. The functional significance of the AOS and its possible occurrence in other vertebrate classes, are discussed.

Animals↗
PubMedDate not supplied

Disease distributions in patients with multiple patterns of nuclear staining detected by FANA (immunofluorescent antinuclear antibody) tests.

The present study examines disease distributions in patients with multiple nuclear immunofluorescent staining patterns detected by FANA testing. Among 4003 consecutive patient sera examined, we found that 813 yielded conventional well-defined single staining patterns, while 46 produced multiple pattern combinations. Homogeneous plus nucleolar was the most prevalent combination, and 5 other combinations were identified. Multiple FANA patterns occurred independently of FANA titers and antibodies to dsDNA and Sm. Compared to control patients with single FANA patterns, patients with multiple patterns were found to have an increased frequency of SLE and diseases of the scleroderma spectrum (DDS) while rheumatoid arthritis (RA) and non-immunologic disease were reduced in frequency. These specific correlations indicate that recognition of multiple FANA patterns adds useful diagnostic information to existing antinuclear antibody testing procedures.

Adult↗