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Biomedical subjects

C Wollschlager

Publications and source records attributed to C Wollschlager.

10 recordsLinked to original sources
PubMed1996

Short-stay comprehensive inpatient pulmonary rehabilitation for advanced chronic obstructive pulmonary disease.

OBJECTIVE: To evaluate the effectiveness of short-term, comprehensive inpatient pulmonary rehabilitation in severe chronic obstructive pulmonary disease (COPD). DESIGN: Retrospective analysis of several outcome measures. SETTING: Inpatient pulmonary rehabilitation unit. PARTICIPANTS: Thirty-eight consecutive adult patients with advanced COPD referred to our inpatient pulmonary rehabilitation program between January 1 and December 31, 1994. All but one were referred from acute care hospitals. The mean forced expiratory volume in 1 second (FEV1) was .69L; 79% required supplemental oxygen. MAIN OUTCOME MEASURES: (1) Discharge status; (2) timed walk, with measurements of distance and exertional dyspnea; and (3) functional status. RESULTS: All patients were able to be discharged home after a mean length of stay of 9.9 days. The 12-minute walk distance increased by 66%, from 416 +/- 282 feet to 690 +/- 337 feet (p < .001). Dyspnea during the walk testing also improved: the resting score decreased from 2.87 to .97, the 6-minute score from 7.84 to 3.05, and postwalk score from 8.53 to 3.51 (all p < .001). All patients showed improvement in the Pulmonary Function Status Scale (PFSS), with the functional activities subsection increasing by 39%, the dyspnea score by 65%, and psychosocial score by 35% (all p < .001). CONCLUSION: Short-term improvement in multiple areas can be accomplished with comprehensive pulmonary rehabilitation of short duration. This is particularly relevant to the current health care environment that dictates shorter in-hospital lengths of stay.

Activities of Daily Living↗
PubMed1992

Incarceration of existing inguinal hernia as a complication of pulmonary function testing.

Pulmonary function testing (PFT) has not been listed as a risk for development of incarceration in an existing inguinal hernia. We report two patients who developed this complication after routine preoperative PFT. We also present data of our retrospective review of eight patients with inguinal hernia who were referred for preoperative PFT. Two out of eight patients suffered incarceration of an existing inguinal hernia. We found no significant difference in mean age, weight, smoking habits, number of forced expiratory maneuvers, time of sustained forced expiratory maneuver, or any PFT data between the groups with and without incarceration. Thus, incarceration of inguinal hernia could not have been predicted prior to PFT and was not related to other factors such as obesity or more severe airway obstruction.

Aged↗
PubMed1987

Ciprofloxacin increases serum levels of theophylline.

During a clinical trial of orally administered ciprofloxacin in respiratory tract infections, changes in serum theophylline levels were evaluated in 33 hospitalized patients who also required theophylline therapy. Patients received intravenous theophylline in standard titrated doses and 750 mg of oral ciprofloxacin twice daily. Serum theophylline levels in all patients were measured before and during ciprofloxacin therapy. The mean serum pretreatment theophylline level was 7.8 +/- 4.6 micrograms/ml; during ciprofloxacin therapy, the level increased to 14.6 +/- 7.4 micrograms/ml. Twenty of the 33 (61 percent) patients evaluated had increases in serum theophylline levels by a mean value of 10.5 micrograms/ml. In 30 percent of patients who experienced increases, theophylline concentrations were in the toxic range. This occurred more frequently in elderly patients with chronic obstructive pulmonary disease. In light of the frequency and potential severity of this interaction, careful monitoring of serum theophylline levels in patients receiving theophylline and ciprofloxacin is recommended.

Administration, Oral↗
PubMed1986

Treatment of respiratory tract infections with ciprofloxacin.

The efficacy and safety of ciprofloxacin in an oral dose of 750 mg twice daily, in the treatment of respiratory infections was studied in 129 patients. Ciprofloxacin showed broad in-vitro antibacterial activity and was highly effective in both Gram-negative and Gram-positive infections with a clinical cure rate of 96%. The major side effect was an interaction with theophylline particularly in the elderly patients.

Adult↗
PubMed1985

Spinal tuberculosis revisited.

Although the incidence of tuberculosis is decreasing, spinal tuberculosis is still an important disease. Delay in diagnosis and treatment results in long-term disability. We reviewed our cases of spinal tuberculosis diagnosed between 1975 and 1982, with special reference to those features that permit early diagnosis. Among the nine cases diagnosed, roentgenographic evidence of pulmonary tuberculosis (7/9) and positive PPD test (8/8) were found to be highly suggestive diagnostic clues. Computerized tomography (CT) of the spine was a useful way of determining the extent of the disease and following response to therapy. Various modes of therapy were used, and the outcome was related to the extent of the disease and duration of symptoms before initiation of therapy. In early stages, medical therapy alone is adequate; surgical intervention is necessary in cases with neurologic features.

Adult↗
PubMed1984

Aspergillomas complicating sarcoidosis. A prospective study in 100 patients.

During a ten-year study period, we evaluated 100 histologically-proven sarcoid patients for the development of aspergillomas. Serum precipitins against Aspergillus antigens were used to screen all patients regardless of sarcoid stage. Twelve patients had serum precipitins and were further investigated with tomography and serial serum precipitins testing. Ten of these 12 patients had aspergillomas and two patients died of massive hemoptysis. No aspergillomas occurred in stages I, II, or non-cystic stage III patients. All ten aspergillomas developed in the 19 stage III patients with cystic parenchymal damage. We believe that aspergillomas in sarcoidosis are not as rare as previously reported, but occur commonly in chronic cystic sarcoidosis. Additionally, we found serial testing for serum precipitins to be valuable both for the screening of cystic sarcoid patients for aspergillomas and for the management of this complication.

Adult↗