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Biomedical subjects

C Wolstrup

Publications and source records attributed to C Wolstrup.

8 recordsLinked to original sources
PubMed1989

Mulberry heart disease in young pigs without vitamin E and selenium deficiency.

Mulberry heart disease persists among young pigs in Denmark although abundant supplies of selenium and vitamin E are added to feedstuffs for sows and pigs. The concentrations of selenium and vitamin E in the liver and heart tissues of young pigs which had died suddenly, and had the characteristic lesions of mulberry heart disease post mortem, were not significantly different from the concentrations found in pigs of the same age which had died suddenly for other reasons. The concentrations of selenium and vitamin E in the livers (0.3 mg/kg and 4 mg/kg, respectively) appeared to be satisfactory in all the pigs examined.

Animals↗
PubMed1989

Epidemiological studies of piglet diarrhoea in intensively managed Danish sow herds. IV. Pathogenicity of porcine rotavirus.

Colostrum-deprived piglets inoculated with rotavirus 24 h after birth developed a profuse diarrhoea that spread to non-inoculated, colostrum-deprived litter mates and, occassionally, to colostrum-fed piglets. Case fatality rates in these 3 categories of piglets were 63.2%, 35.7% and 8.3%, respectively. Surviving piglets recovered in 1-2 weeks, but shedded virus via the faeces for up to 3 weeks p.i. The D-xylose test revealed severe malabsorption, with extremely flat absorption curves for up to 3-4 weeks p.i. Malabsorption was more marked in piglets with a long-lasting faecal virus excretion than in piglets where virus disappeared from the faeces within 10 days p.i. Infected piglets (colostrum-fed and colostrum-deprived) had decreased weight gains and were 5 days older at a bodyweight of 25 kg than non-inoculated controls. It is concluded that rotavirus is probably of significance in diarrhoeal syndromes in suckling piglets, alone or in combination with E. coli or other pathogens.

Animals↗
PubMed1989

Excessive dietary selenium to primiparous sows and their offspring. I. Influence on reproduction and growth.

The effect of high dietary selenium (Se) on the reproductive performance, growth and health in pigs was examined. Addition of 0 to 16 mg Se per kg feed to sows and their piglets up to nine weeks of age did not cause any manifest toxic effect. None of the sows died due to the Se treatment. The piglets were all fullborn and showed no macroscopic abnormalities. The treatment did not influence neither the number of liveborn and stillborn piglets in the litter, nor the survival of the piglets until 9 weeks of age. The weight of the whole litter at birth was unaffected by the Se supplementation, while there was a significant difference in body weight of the piglets at 9 weeks of age. The weaned pigs receiving 8 or 16 mg Se per kg feed had a reduced feed intake. As the feed utilization was unaffected by treatment, these pigs had a significantly lower weight at 9 weeks of age.

Animals↗
PubMed1987

A murine model for the assessment of placental and fetal development in teratogenicity studies.

During normal pregnancy in the mouse, maternal serum levels of the analogues to human schwangerschaftsprotein-1 and alpha-fetoprotein correlate significantly with the growth of the placenta and fetus respectively. This relationship has been utilized in the analysis of the effect of sodium selenite on placental and fetal growth in mice. Moderate doses of sodium selenite did not affect the growth of the placenta and fetus significantly, whereas high doses of selenite resulted in a large percentage of abortions. The protein markers were found to be useful in the prediction of placental and fetal growth, and they are suggested to be of general use in the study of the impact of teratogenic substances, since they reflect the status of the fetoplacental mass during gestation.

Abnormalities, Drug-Induced↗
PubMed1981

Lead pellets in Danish cattle.

A survey was made in order to estimate the occurrence of lead pellets in the reticulum of Danish cattle and the consequential increase if any, in the lead concentration in liver and kidney tissue of the animals concerned. The investigation comprised the contents of the reticulum from 415 head of cattle, males and females, adults and calves. Furthermore, livers, and/or kidneys from 34 head of cattle, with and without lead pellets in the reticulum, were analysed for lead. A total of 1120 lead pellets were found in 230 (55%) of the cattle (Table II) the number of pellets per individual ranging from 1 to 55 with an average of 0.47 gram lead in each of the 230 animals. The weight of the lead pellets found in the reticulum was 20--40% lower than that of similar pellets from unfired cartridges. (Fig. 1, Table I), indicating a partial dissolution of the pellets during their stay in the reticulum. No correlation was established between the number of lead pellets in the reticulum and the lead content in the liver and the kidneys (Fig. 2), and no increase was found in the lead content in the organs.

Animals↗
PubMed1978

Copper load in Mute Swans (Cygnus olor) found in Denmark.

Organs from 91 Mule Swans were analyzed for copper and lead. Swans from an area known to be polluted with copper had an average copper content in their livers of nearly 1100 mg/kg or more than twice as much as swams from other parts of Denmark.

Animals↗
PubMed1976

Zinc as a possible causal factor in the sterilizing sperm tail defect, the 'Dag-defect', in Jersey bulls.

The zinc content was determined in semen samples from four young Danish Jersey bulls showing the typical 'Dag defect' (greater than 50% strongly coiled or bent sperm tails). Two of the bulls were half brothers. Semen samples from 14 normal fertile Jersey bulls served as controls. The normal material showed a zinc content in the centrifuged sperm of 190 +/- 15.8 mug/g d.w. and in the seminal plasma 81 +/- 31.2 mug/g d.w. In the four abnormal bulls the following elevated values were found: in the centrifuged sperm 310 +/- 109.5 mug/g d.w. and in the seminal plasma 137 +/- 75.2 mug/g d.w. (see figs. 1 and 2). One of the Dag defect's main localizations, the outer dense tail fibers, has a very high zinc content and this fact together with the heredity of the defect make further studies most promising.

Animals↗