Biomedical subjects

C X Zhou

Publications and source records attributed to C X Zhou.

7 recordsLinked to original sources

PubMed2006

Fiber-optic Fabry-Perot sensors based on a combination of spatial-frequency division multiplexing and wavelength division multiplexing formed by chirped fiber Bragg grating pairs.

Effective multiplexing for a very large number of fiber-optic fiber-Bragg-grating-based Fabry-Perot (FBGFP) sensors is proposed that is based on wavelength division multiplexing (WDM) and spatial-frequency division multiplexing (SFDM). For WDM, FBGFP sensors are arranged in different wavelength domains formed by a series of chirped fiber Bragg gratings with different central wavelengths while the sensors with different cavity lengths within the same wavelength domain are multiplexed by use of SFDM because they have different spatial frequencies as a result of their different cavity lengths. In principle, a thousand FBGFP sensors could be multiplexed with such an approach. The experimental results show that a strain accuracy of better than +/-10 microepsilon has been achieved with little cross talk.

Journal Article↗

PubMed2006

Demodulation algorithm for spatial-frequency-division-multiplexed fiber-optic Fizeau strain sensor networks.

A demodulation algorithm for spatial-frequency-division-multiplexed fiber-optic Fizeau strain sensor networks with a large number of sensors is proposed to effectively reduce the cross talk between any two adjacent sensors and hence substantially enhance the multiplexing capability of the network, which is based on the Pisarenko algorithm. The cross talk between two fiber-optic Fizeau sensors is investigated experimentally. The experimental results show that a strain accuracy of better than +/-10 micro permittivity can be achieved even when the cavity length difference is approximately 100 microm. It was demonstrated that the multiplexing capability of the spatial-frequency-division-multiplexed fiber-optic Fizeau sensor network can be approximately 5 times greater than that of the conventional fast-Fourier-transform algorithm, and this can lead to achievement of a sensing network with a multiplexing capability of as many as 1000 Fizeau sensors.

Journal Article↗

PubMed2002

Cellular signaling mechanisms underlying pharmacological action of Bak Foong Pills on gastrointestinal secretion.

Bak Foong Pills (BFP, also known as Bai Feng Wan) is an over-the-counter traditional Chinese medicine that has long been used for treating gynecological disorders and improving overall body functions, including gastrointestinal (GI) function. However, the cellular signaling mechanism underlying BFP action, especially on the GI tract, has not been elucidated. In the present study, the human colonic epithelia cell line T(84) was used as a model to investigate the effect of BFP ethanol extract on ion transport in conjunction with the short-circuit current (I(SC)) technique. The results showed that the apical addition of BFP extract produced a concentration-dependent (10-1,000 microg/ml, EC(50) = 120 microg/ml) increase in I(SC). The maximal response was observed at 500 microg/ml with an increase in I(SC) of 24.4 +/- 2.3 microA/cm(2) and apical conductance. The BFP-induced I(SC) was not observed when extracellular Cl(-) was replaced or when treated with Bumetanide (100 microM), an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter. The BFP-induced I(SC) was insensitive to the Na(+) channel blocker, amiloride, but partially inhibited by the Cl(-) channel blocker, DIDS (100 microM), and completely blocked by DPC (2 mM) or glibenclamide (1 mM) with a significant reduction in the apical conductance. The BFP-induced I(SC) could be mimicked by forskolin (10 microM), but inhibited by a pretreatment of the cells with adenylate cyclase inhibitor, MDL-12330A (10 microM). Pretreatment with EGTA (5 mM) and thapsigargin (10 microM) decreased the BFP-induced I(SC) by 10%. These results demonstrated that BFP ethanol extract exerted a stimulatory effect on gastrointestinal Cl(-) secretion by predominantly activating adenylate cyclase and apical cAMP-dependent Cl(-) channels, with minor contributions from calcium-dependent Cl(-) channels. The effect of BFP may be explored to treat GI disorders such as constipation.

Adenylyl Cyclases↗

PubMed2001

Syntheses of hydrated molybdenum bronzes by reduction of MoO3 with NaBH4.

Hydrated molybdenum bronzes have been prepared by reduction reaction of MoO3 with NaBH4 in ethanol and DMSO. The reduction reactions in both solvents occur smoothly; thus, the layered structure of MoO3 is maintained in the product. Divalent cation Ca2+ has been intercalated between the MoO3 layers, which leads to highly reduced molybdenum bronze (Mo5.26+). Solvated molybdenum bronze catalyzes the reduction reaction of DMSO by NaBH4, producing CH3SCH3. The structure model of hydrated sodium molybdenum bronze has also been reinvestigated by using the Rietveld analysis. The hydrated molybdenum bronze crystallizes in an orthorhombic structure, in which the structure of Mo octahedron layers is closely related to that in MoO3. However, the structure refinement reveals that the Mo octahedron in the MoO3 layers is axially distorted, which is different from that in MoO3 but similar to an isoelectron compound H0.33MoO3.

Journal Article↗

PubMed2001

Glycosides and xanthine oxidase inhibitors from Conyza bonariensis.

Fractionation of the xanthine oxidase inhibitory methanol extract of Conyza bonariensis afforded three glycosides, in addition to nine known compounds including amyrin, beta-sitostero1 daucosterol, syringic acid 3-hydroxy-5-methoxybenzoic acid, eugenol 4-O-glucopyranoside, and luteolin, apigenin and takakin 8-O-glucuronide. The structures of the glycosides were established by a combination of spectroscopic methods (IR, MS, 1H and 13C NMR, DEPT, COSY, HMQC and HMBC) as 4-hydroxypyridin-3-carboxylic acid 4-O-glucopyranoside, 8-hydroxy-6,7-dihydrolinalool 8-O-glucopyranoside and bonaroside [viz. 1,3,4,12-tetrahydroxy-2-(9-hexadecenoylamino)octadecane 1-O-glucopyranoside]. The in vitro enzyme assay showed that syringic acid and takakin 8-O-glucuronide displayed weak inhibitory activity against xanthine oxidase with IC50 values of 500+/-41 microM and 170+/-12 microM, respectively.

Asteraceae↗

PubMed2001

Inhibition of xanthine and monoamine oxidases by stilbenoids from Veratrum taliense.

The bioassay guided refractionation of the methanol extract of roots and rhizomes of Veratrum taliense (Liliaceae) yielded five stilbenoids: veraphenol, resveratrol, piceid, isorhapontin, and mulberroside E, all inhibiting xanthine oxidase (XO, EC 1.2.3.2.) in vitro in a dose-dependent manner with IC50 values of 11.0, 96.7, 66.1, 70.0, and 78.4 microM, respectively. Veraphenol and mulberroside E were found to be mixed XO inhibitors with the Ki and Ki data of the former being 32.8 and 239.3 microM, and those of latter 32.5 and 13.8 microM, respectively. However, the inhibition on the enzyme by resveratrol, isorhapontin, and piceid was shown to be competitive with their Ki values of 9.7, 19.1, and 14.3 microM, respectively. Among the five stilbenoids, veraphenol and resveratrol were also revealed to inhibit competitively monoamine oxidase A (MAO, EC 1.4.3.4) with IC50 values at 38.0 and 26.6 microM, and Ki data 36.4 and 47.3 microM, respectively. However, none of the stilbenoids was inhibitory on MAO B in our assay. The structure-activity relationship examination showed that glycosylation of the stilbenoids could reduce the inhibition on XO and diminish the activity against MAO A, indicating that the free phenolic hydroxy group of the compounds was most likely essential for these bioactivities.

Animals↗

PubMed2001

[Studies on the stability of ligustilide with solvent effect].

AIM: To study the stability of ligustilide with solvent effect and try to disclose the relationship between its stability and solvent effect, so as to develop a useful method for its preservation. METHODS: The model of PCM solvent effect was used to carry out quantum chemistry calculation. The GC/MS spectrum was used to study the stability of ligustilide in solvent at room temperature. RESULTS: Ligustilide is more stable in cyclohexane and chloroform than in air. The isomerization rate of ligustilide decreased remarkably to 1.6% and 6.7% in cyclohexane and chloroform compared to 58% in air. CONCLUSION: The stability of ligustilide is greatly improved with the solvent effect. Keeping ligustilide in proper organic solvent is helpful to prevent its isomerization.

4-Butyrolactone↗