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Biomedical subjects

C Y Genton

Publications and source records attributed to C Y Genton.

At least 19 recordsLinked to original sources
PubMed1992

[Reliability of bronchial tumor typing base on fibroscopically obtained biopsies].

This study is based on the bronchial tumors biopsied and later examined between 1971 and 1986 at the Institute of Pathology, Lausanne. In each case the diagnosis based on the initial biopsy material is compared with the final surgical or autopsy diagnosis (Reference: Histological typing of lung tumours, second edition, WHO, 1981, 2). The series studied is constituted by 163 cases: 144 men (88.3%) and 19 women (11.7%). In 136 cases (83.4%), the biopsy diagnoses are identical to the diagnoses based upon surgical or autopsy material; in 27 cases (16.6%) these diagnoses differ. The positive predictive value of bronchial biopsy appears to be excellent (100%) for small cell and epidermoid carcinoma (CA). It is satisfactory for adenocarcinoma (85.7%) but insufficient for large cell CA (42.3%) and the tumors grouped under "others" (50%). The diagnosis of large cell CA, in situ CA, papillary tumor, undifferentiated CA, or carcinomatous lymphangitis should be considered with caution and in some cases it is advisable to repeat the biopsy. The discrepancies between the initial and final diagnoses can, in all cases, be attributed either to the biopsy specimen being too small and therefore nonrepresentative or, less frequently, to crushing and necrosis of the tissues.

Autopsy↗
PubMed1992

[Rapidly destructive lumbar spondyloarthropathy in chronic hemodialysis].

Rapidly destructive spondyloarthropathy occurring in the lumbar spine of 2 chronically hemodialysed patients is reported. These lesions resembled infectious spondylitis. Histological examination revealed deposits of amyloid in the L3-L4 intervertebral space in one patient, which could be a causative factor in the joint destruction. The other favouring circumstances and pathogenesis of this condition are discussed.

Aged↗
PubMed1988

[Papillary-cystic tumor of the pancreas in young women].

A case of papillary-cystic (solid cystic) tumor of the pancreas in a 15-year-old woman is presented. This type of tumor is of low grade malignancy and is without endocrinological activity. It is usually found in young women. The treatment is surgical resection.

Adolescent↗
PubMed1987

Vulval liposarcoma.

A 60-year-old woman complained about an indolent and slowly growing tumor of the vulva. Clinical examination showed a sharply circumscribed lump in the posterior part of the left labium majus, suggestive of a cyst of Bartholin's gland. At operation a solid, macroscopically encapsulated tumor was found, which was a mostly well-differentiated liposarcoma on histological examination. Ten months after operation, the patient was well and had no signs of local or distant recurrence. The clinical and pathological features of this extremely rare case are presented and discussed.

Female↗
PubMed1986

[Nongynecological occult cancers diagnosed in the course of their ovarian metastases. A clinical and anatomicopathological study of 8 cases].

Malignant non-gynecological diseases manifested through ovary metastases are rare but not exceptional. In routine histological examinations of the ovary within the last 6 years we have found an unknown non-gynecological disease in 8 patients undergoing surgery in the gynecological clinic in Zurich. One lobular bilateral breast cancer, one pancreatic cancer, three stomach cancers and three lymphomas were diagnosed. The symptoms, treatment, prognosis and anatomo-pathological aspects are discussed.

Adenocarcinoma↗
PubMed1985

[A case of vaginal adenocarcinoma after uterine exposure to diethylstilbestrol].

From 1946 to 1971, diethylstilbestrol, a nonsteroid synthetic estrogen, came in for widespread use in the USA, and in other countries only occasional use, for the treatment of high-risk pregnancies. In 1971 a retrospective epidemiologic study showed a close association of this therapy with occurrence of vaginal and cervical adenocarcinoma in young women (mean age 19 years). Up to 1981 63% of 429 clear cell carcinomas of the vagina and cervix were related to DES exposure in utero in the USA. Following reports on a few cases in other countries, the present report is the first in a Swiss female, aged 23, with stage III DES-induced adenocarcinoma of the vagina. The risk of DES-related adenocarcinoma is estimated at about 1%, but benign teratogenic lesions are present in over 50% of patients. Vaginal adenosis is the most frequent finding, but other malformations of vagina (septa), cervix, uterus and fallopian tube may be found. Malformations of the genital tract have also been described in DES-exposed male offspring.

Adenocarcinoma↗
PubMed1985

[Purely mesenchymal homologous uterus sarcomas (leiomyosarcomas and endometrial stroma sarcomas) at the Zurich University Gynecologic Hospital].

From 1960 through 1983 sixty-four so-called pure mesenchymal homologous sarcomas of the uterus were observed at the Women's University Hospital Zürich. A review of the histological slides revealed that only 40 cases represented true sarcomas according to the contemporary diagnostic criteria. These were 25 leiomyosarcomas and 15 endometrial stromal sarcomas. Leiomyosarcomas: The leading symptoms in these patients are uncharacteristic abdominal pain (15/25) as well as bleeding disturbances (11/25), the latter being present with equal frequency in the pre- and post-menopause. In 7 of the 11 patients with bleeding abnormalities the diagnosis was already made on examination of curettings, in all the other patients after laparotomy only. Sixteen patients had Stage I, four Stage III and five Stage IV tumors. The treatment consisted in surgery alone (9/25), surgery combined with radiotherapy (11/25) or with chemotherapy (2/25) as well as radiotherapy alone (1/25). In two cases no therapy was undertaken because of advanced cachexia of the patients. Only three patients are still alive without recurrence 4 to 12 years after the diagnosis, all had Stage I tumors. Endometrial stromal sarcomas: In these patients bleeding abnormalities represent the leading symptom (14/15), especially postmenopausal bleeding (13/14). In all cases with vaginal bloody discharge the diagnosis was made on examination of the curettings, in a single case after laparotomy only. Eight patients had Stage I, three Stage II, three Stage III and one Stage IV tumors. The treatment consisted of surgery alone (4/15) or in combination with radiotherapy (4/15), radiotherapy alone (6/15) and chemotherapy alone (1/15).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

[Unrecognized malignant lymphomas simulating a primary gynecologic malignancy].

The discovery of a so far unknown lymphoma in the female genital tract is rare. According to Chorlton et al., malignant lymphoma manifests itself primarily in the ovary and uterus in 0.3% and 0.12% of cases respectively. Four personally observed cases are reported with special emphasis on the clinical and histological difficulties encountered in the diagnosis of this rare clinical picture. After analysis of data in the literature, an attempt is made to define criteria, which should lead clinicians and pathologists to consider the possibility of such an event. Women of all age groups may be affected. Malignant lymphoma occurring primarily in the uterus usually mimics infiltrative carcinoma of the cervix causing vaginal discharge and post-coital bleeding. There are no specific symptoms. The presence of an undifferentiated round-cell tumor which is difficult to classify histologically and develops rapidly should suggest the possibility of malignant lymphoma. When the primary manifestation is an ovarian tumor, the lesion is bilateral in about 55% of cases. The presence of ascites is very rarely reported. In most cases these tumors are histologically misdiagnosed primarily as granulosa cell tumors, dysgerminomas or undifferentiated carcinomas. The diffuse and poorly differentiated lymphocytic type is most frequently encountered in adults. In children, granulocytic sarcoma or so-called chloroma may be found. In the presence of bilateral ovarian tumor without ascites and displaying unclear histological features in frozen sections, the possibility of malignant lymphoma should always be considered. In such cases it is advisable to process some of the tumor tissue for special subsequent morphologic and/or immunologic investigations.

Adolescent↗
PubMed1984

[Milk-duct papillomas of the breast: diagnosis, clinical course, morphology and associated pathology].

From 1978 through 1982, 52 cases of benign intraductal papilloma were observed in the Histopathology Laboratory of the University Women's Hospital, Zürich. The neoplasms were solitary in 20 cases and multiple in 32. Symptomatology, diagnosis and therapy of these tumors are presented and discussed. The indication for biopsy or further histological examination was a pathological palpatory finding (54%), discharge from the nipple (36.5%), or an incidental mammographic finding (9.5%). Five (15.5%) of the 32 patients with multiple intraductal papilloma, but none of those with solitary papilloma, had an associated carcinoma in the same breast.

Adolescent↗
PubMed1984

[Prognostic significance of pelvic lymph node metastases in surgically treated cervical cancer].

The prognostic significance of pelvic lymph node metastases in cases of invasive cervical carcinoma treated by radical hysterectomy (meigs- Okabayashi -Held) was analysed in a series of 142 patients who underwent such a procedure during the past ten years at the Gynecological University Hospital in Zurich. Discrepancies between clinical and anatomical staging were noted in 24.6% of the cases. Anatomically, 6 neoplasms were stage Ia lesions, 96 stage Ib, 9 stage IIa and 7 stage IIb. Pelvic lymph node metastases were found in 24 further cases (16.9%) which had, therefore, to be classified as anatomic stage III. The tumour recurred postoperatively in only 9 of the 118 patients (7.6%) with anatomic stage Ia-IIb lesions, but in 10 of the 24 patients with stage III carcinomas (41.7%). In this series, none of the relapsing tumours could be cured, whatever the treatment was. This means that the 6 times higher recurrence rate observed in cases with pelvic lymph node metastases also implicates a 6 times higher mortality.

Adenocarcinoma↗