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C Y Ni

Publications and source records attributed to C Y Ni.

4 recordsLinked to original sources
PubMed2001

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase.

ErbB-4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding of its ligand heregulin (HRG) or activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA), the ErbB-4 ectodomain is cleaved by a metalloprotease. We now report a subsequent cleavage by gamma-secretase that releases the ErbB-4 intracellular domain from the membrane and facilitates its translocation to the nucleus. gamma-Secretase cleavage was prevented by chemical inhibitors or a dominant negative presenilin. Inhibition of gamma-secretase also prevented growth inhibition by HRG. gamma-Secretase cleavage of ErbB-4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.

Active Transport, Cell Nucleus↗
PubMed2001

Cardiac troponin I: a biomarker for detection and risk stratification of minor myocardial damage.

Myocardial infarction has long been a subject of research in cardiology and biochemistry. Within the past few years, a number of new phrases, micro-infarction, minor cardiac damage and non-ischemic cardiac damage have been frequently used and discussed since cardiac troponin I (cTnI) was introduced. Using this sensitive and specific biomarker it is now possible to detect minor cardiac damage occurring in different clinical settings: spontaneous, trauma, thermal injury, septic shock, or during cardiovascular surgery. The advent of this marker also opens a subject on the pathophysiologic aspect of non-ischemic cardiac damage that has not yet been fully understood and verified. This article reviews current knowledge of cTnI and its relationship with unstable angina and non-ischemic cardiac damage. The clinical implication of recent research findings on cTnI is also discussed.

Angina, Unstable↗