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Biomedical subjects

C Y Su

Publications and source records attributed to C Y Su.

At least 73 records · Page 4Linked to original sources
PubMed1995

A study of pinch strength in normal Taiwanese adults.

The purpose of this study was to describe norms of pinch strength for normal Taiwanese adults and to investigate the effects of age, gender, height, weight, and digit length on pinch strength. Three types of pinch (i.e. tip, key, and palmar pinch) were measured for a sample of 356 adults aged 20 to 88 years from a major metropolitan city located in southern Taiwan. A newly calibrated B&L pinch gauge was used for strength measurements with a standardized position during testing. The dominant hand was tested first, followed by the nondominant hand. The average of two trials for each pinch strength test was used as the subject's test scores. The results indicated that in the male group, pinch strength remained relatively stable up to 50 to 59 years old before a decline began, whereas pinch strength peaked with the 40- to 59-year-old group for female subjects. Males were stronger than females on all prehension patterns. Pinch strength of the right hand was significantly affected by such variables as the lengths of thumb and index finger and height, along with weight. With regard to the left hand, only height and weight had significant impact on pinch strength. Finally, there was an overall 13% pinch strength difference between the dominant and nondominant hands for the total sample. These findings provide therapists with objective data concerning the pinch strength of the Taiwanese adult's hand for clinical use.

Adult↗
PubMed1995

[Brain abscess as a complication of ear malignancy: a case report].

Ear infection is the most common cause of brain abscess. A suppurative process in the ear has access to the central nervous system by direct extension or through preformed pathways, either developmental, traumatic or pathologic, or by retrograde spread along the thromobophlebitic vein. Squamous cell carcinoma of middle ear or mastoid cavity is a rare disease and often associated with chronic otitis or chronic draining ear. Ear malignancy easily produces the destruction of temporal bone which may serve as a route for coexistent infection spreading into the brain. This paper reports a case of brain abscess occurring in a patient with temporal bone cancer. To the best of our knowledge, no more than three similar cases have been reported in the literature. The authors suggest that if an otogenic brain abscess is concomitant with infection and granulomatous mass in the ear, biopsy should be performed to rule out malignancy.

Brain Abscess↗
PubMed1994

Grip strength in different positions of elbow and shoulder.

This study investigated the effect of shoulder position on grip strength in 80 men and 80 women. A Jamar dynamometer was used to measure the grip strength in the four testing positions. The four hand strength tests consisted of three positions in which the elbow was maintained in full extension combined with varying degrees of shoulder flexion (ie, 0 degrees, 90 degrees, and 180 degrees) and of one position in which the elbow was flexed at 90 degrees with the shoulder in 0 degrees of flexion. Only the dominant hand was tested. The highest mean grip strength measurement was recorded when the shoulder was positioned at 180 degrees of flexion with elbow in full extension; whereas the position of 90 degrees elbow flexion with shoulder in 0 degrees of flexion had the lowest grip strength score. In addition, the grip strength measured with the elbow in extension, regardless of shoulder position (ie, 0 degrees, 90 degrees, and 180 degrees of flexion), was significantly higher than when the elbow was flexed at 90 degrees with the shoulder positioned at 0 degrees of flexion. Finally, grip strength differed significantly for both sexes and for each age group. The grip values of the standardized 90 degrees elbow flexed position were further analyzed to determine the average performances in the study population. For men, grip strength peaked within the 20 to 39 years age group and gradually declined thereafter. For women, the highest mean grip strength measurement was recorded in the 40- to 49-year-old age group and then deteriorated with age.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1994

[Pharmacokinetics and disposition of vinpocetine in rats].

A reverse-phase HPLC method for determination of vinpocetine in biological samples was developed. The method was simple, highly specific and accurate. After i.v. administration of vinpocetine in rats, the plasma concentration-time curves of vinpocetine was found to be fitted to a two-compartment open model. Dosing 5 and 10 mg.kg-1 vinpocetine in rats, the elimination of the drug from plasma accorded with linear kinetics and the elimination half-lives were shown to be 1.76 +/- 0.27 h. The volumes of distribution were 7.30 +/- 0.49 L.kg-1 (5 mg.kg-1) and 6.07 +/- 0.67 L.kg-1 (10 mg.kg-1) respectively. The drug levels were high in the lung, spleen, liver and kidney, moderate in brain, fat and testis and low in heart, muscle and blood. Our results demonstrate that vinpocetine was eliminated in a rapid rate and distributed widely in the body. The bioavailability of vinpocetine after ig administration was 54.54% in rats. A small amount of unchanged vinpocetine was detected in urine, feces and bile after i.v. and ig administration.

Animals↗
PubMed1994

Kimura's disease--report of four cases.

Kimura's disease is a rare benign condition that occurs predominantly in Oriental young people. The patients displayed a variety of manifestations such as painless, tumor-like masses in the head and neck regions, or in the salivary glands with associated lymphadenopathy. They are sometimes initially mistaken for malignant tumors, resulting in improper management. We present four cases of Kimura's disease and a comprehensive review of the literature to increase awareness and alert surgeons and pathologists to consider the possibilities of this disease, especially in Oriental patients having peripheral blood eosinophilia and/or elevated serum IgE.

Adult↗
PubMed1994

Performance of normal Chinese adults on grip strength test: a preliminary study.

This study investigated grip strength performance in normal Chinese adults. Grip strength of 160 Chinese subjects (80 males and 80 females) from a major metropolitan city in southern Taiwan was measured with a newly calibrated Jamar dynamometer. The subject was tested in a standing position, with shoulder adducted and neutrally rotated, elbow flexed at 90 degrees and forearm and wrist in neutral position. Subjects exerted one maximal effort with both right and left hands. Results indicate that the grip strength of Chinese males peaked within the 20 to 39 year-old group. For Chinese females, the highest grip strength score occurred in the 40 to 49 year-old age group and declined as a function of age. Males consistently had higher grip strength than females across age ranges. Finally, there was no 10% variance in grip strength from the dominant to nondominant hand for each age group of both sexes. Instead, there were 49 (31%) of all subjects who had nondominant hand strength scores that were equal to or greater than their dominant hand strength scores. Clinical implications and recommendations for future research are suggested.

Adult↗
PubMed1993

Electromyographic study of tensor and levator veli palatini muscles in patients with nasopharyngeal carcinoma. Implications for eustachian tube dysfunction.

BACKGROUND AND METHODS: To research the pathophysiology of the Eustachian tube (ET), electromyographies (EMG) of the tensor and levator veli palatini muscles (TVP and LVP) in 46 fresh specimens of nasopharyngeal carcinoma (NPC) were studied. RESULTS: Sixty-eight percent of the TVP on the symptomatic side had abnormal EMG. Normal EMG recordings were noted in all TVP on the asymptomatic side. The abnormal TVP EMG observed most often was poor interference pattern or decreased interference with swallowing, and not uncommonly, there were some abnormal motor unit action potentials of serrated or large polyphasic waveforms found on motor unit potential analysis. This is strong evidence of neurogenic abnormality of the TVP caused by the NPC invasion. Despite the large polyphasic or serrated action potentials often being recorded on the symptomatic sides of LVP, the abnormal EMG finding also was found in 12 LVP on the asymptomatic sides. CONCLUSIONS: There was no evidence that an ET dysfunction could be caused solely by an abnormal LVP function. This investigation and the study of ET function of these patients demonstrate that functional obstruction induced by the invasion of NPC to the nerve of TVP, rather than mechanical obstruction caused by the tumor mass effect on the ET, gives rise to the ear symptoms and signs of these patients. The authors suggest that the LVP action has little or no role in the function of the ET.

Acoustic Impedance Tests↗
PubMed1993

Near-total laryngopharyngectomy with pectoralis major myocutaneous flap in advanced pyriform carcinoma.

Successful restoration of phonation, as well as swallowing in laryngopharyngeal surgery for patients with advanced pyriform carcinoma still remains a major challenge. In a five-year period, near-total laryngectomy operations were performed on 21 patients with laryngopharyngeal carcinoma. This report particularly emphasizes the value of near-total laryngopharyngectomy with a pectoralis major myocutaneous flap for four extensive hypopharyngeal carcinoma cases (three of which were of pyriform origin). All four patients regained intelligible shunt speech and smooth swallowing. The follow-up period ranged from 19 to 44 months. They have had no recurrence of disease since surgery. The authors suggest that an advanced pyriform carcinoma case, with a normal contralateral hemilarynx and pyriform sinus, is a candidate for a near-total excision of the laryngopharynx.

Aged↗
PubMed1993

External ear canal schwannoma: an unusual case report.

To the best of our knowledge, this is the first report of external ear canal schwannoma in the English literature. Several detailed clinical and pathological features were demonstrated. We suggest that if a tender, encapsulated mass is found in the external ear canal, the diagnosis of schwannoma should be taken into consideration.

Ear Canal↗
PubMed1993

Treatment of vitreous floaters with neodymium YAG laser.

Fifteen cases of vitreous floaters with serious psychological reactions have been collected. By using a direct ophthalmoscope, causal vitreous opacities were detected. The opacities were photodisrupted with neodymium YAG laser, using energy levels of 5 to 7.1 mJ and total energy 71 to 742.0 mJ. Symptoms completely disappeared immediately after treatment in all 15 cases. There were no intraoperative or postoperative complications noted during a follow up period of at least 1 year. To our knowledge, the use of neodymium YAG laser to treat vitreous floaters has not been previously described. Our initial experience indicates that the treatment is simple, safe, and effective.

Adult↗
PubMed1993

Computed tomography, magnetic resonance imaging, and electromyographic studies of tensor veli palatini muscles in patients with nasopharyngeal carcinoma.

One of the factors that induces eustachian tube dysfunction caused by the invasion of nasopharyngeal carcinoma is paralysis of the tensor veli palatini muscle. Electromyography (EMG), computed tomography (CT), and/or magnetic resonance imaging (MRI) were used to study the tensor muscle and the related paratubal structures and parapharyngeal space. This study, from 44 patients with nasopharyngeal carcinoma, showed that 67% of tensor muscles on the side of the symptomatic ear yielded abnormal electromyographic waveforms, which usually indicated a neurogenic disorder. In the majority of the abnormal EMG cases, CT or MRI often revealed that the pharyngobasilar fascia and the tensor muscle were compressed anterolaterally and the upper prestyloid parapharyngeal space was infiltrated. It was found that an abnormal electromyogram of the tensor muscle generally suggested a more advanced T stage and eustachian tube dysfunction. Otitis media with effusion in the stage I cases was usually not caused by paralysis of the tensor muscle. The invasion of some early cancers, especially localized on the torus tubarius, could also cause the effusion.

Adolescent↗
PubMed1993

Grip strength: relationship to shoulder position in normal subjects.

The objective of this study was to evaluate the effect of shoulder position on grip strength. A Jamar dynamometer was used to measure the grip strength of 160 subjects (80 males and 80 females), stratified on both sex and age, in the four testing positions. For each of the tests of grip strength, the subject stood with the shoulder adducted and neutrally rotated while the forearm and wrist were held in the neutral position. The four hand strength tests consisted of three positions in which the elbow was maintained in full extension combined with varying degrees of shoulder flexion (i.e., 0 degree, 90 degrees, and 180 degrees) and of one position in which the elbow was flexed at 90 degrees with the shoulder in 0 degree of flexion. Only the dominant hand was tested. The results showed that the highest mean grip strength measurement was recorded when the shoulder was positioned at 180 degrees of flexion with elbow in full extension; whereas the position of 90 degrees elbow flexion with shoulder in 0 degree of flexion had the lowest grip strength score. In addition, the grip strength measured with the elbow in extension, regardless of shoulder position (i.e., 0 degree, 90 degrees, and 180 degrees of flexion), was significantly higher than when the elbow was flexed at 90 degrees with the shoulder positioned at 0 degree of flexion. Finally, grip strength differed significantly for both sexes and for each age group. The findings are valuable in the evaluation and rehabilitation training of hand injured patients.

Adult↗
PubMed1992

Selective reduction of creatine kinase subunit mRNAs in striated muscle of diabetic rats.

Creatine kinase (CK) is important for energy transfer and is composed of mitochondrial (mitCK), muscle (MCK), and brain (BCK) subunits, each being the product of separate nuclear genes. The concentrations of MCK and BCK mRNAs have been shown to decrease in streptozotocin-hypoinsulinemic rat hearts, and in this report, we examined in detail the diabetic effect on CK gene expression in cardiac muscle and in two types of skeletal muscle. The level of sarcomeric mitCK mRNA was not altered in the diabetic myocardium, but was reduced by 86 and 67% in diabetic slow-twitch soleus muscle and fast-twitch extensor digitorum longus (EDL) muscle, respectively. MCK mRNA was also lowered in diabetic soleus muscle by 56%, while it remained at control levels in diabetic EDL. In both skeletal muscles, at either state, BCK mRNA was not detectable. There was a 33% decrease in total CK activity in diabetic cardiac and soleus muscle, but not in EDL. Diabetes thus exerts a widespread, muscle type-dependent adverse effect on CK expression that we found to be insulin therapy revertible. This study adds to our understanding of defective energy transduction in diabetic muscle.

Animals↗
PubMed1992

Idiopathic palatal myoclonus: report of two cases.

We report two patients with idiopathic palatal myoclonus presenting as a synchronous up-and-down beating of the soft palate, to-and-fro thrusting of the tongue, and contraction of pharyngeal and laryngeal muscles. The obvious pulsatile movements were visible on the submental surface and a loud clicking noise was audible from a distance. The involuntary jerkings predominantly appeared when the mouth was kept shut, but could be interrupted by some oro-lingual maneuvers such as phonation, swallowing, and sticking the tongue out. Although the palatal myoclonus did not affect the function of the mouth, the patients were socially embarrassed by the loud clicking sound and pulsatile movements. On clinical examination and laboratory investigations, no evidence of lesion in the brainstem or cerebellum was obtained. A therapeutic trial with trihexyphenidyl did not bring any benefit. To conclude, because the idiopathic palatal myoclonus is a rare movement disorder which has never been documented in Taiwan, we describe its clinical characters in two Chinese patients and discuss the differential diagnosis with other involuntary lingual movements.

Adult↗
PubMed1992

[Chronic cold agglutinin disease occurring after a diagnosis of aplastic anemia].

We report herein a 61-year-old man with chronic cold agglutinin disease which occurred after a diagnosis of aplastic anemia. The patient's pancytopenia was recognized upon visiting a local doctor because of high fever and cough on December 21, 1985. He was subsequently admitted to our hospital because of anasarca on January 31, 1986, and was diagnosed as having aplastic anemia. He was treated with prednisolone, and was discharged after his anemia improved. He was readmitted on October 23, 1988, because of icterus. Laboratory data on the patients second admission revealed increased reticulocyte count, hyperplastic bone marrow with a predominance of erythroblasts, increased serum indirect bilirubin, increased serum LDH1 value and decreased serum haptoglobin. Moreover, cold agglutinin titer was increased, anti-IF antibody was positive, and anti-IgM antibody was recognized with direct anti-globulin test. There was no precedent infection such as mycoplasma pneumonia or infectious mononucleosis. Hence, this patient was diagnosed as having chronic cold agglutinin disease.

Anemia, Aplastic↗
PubMed1991

Induction of hepatic mitochondrial glycerophosphate dehydrogenase in rats by dehydroepiandrosterone.

Feeding the thermogenic steroid, 5-androsten-3 beta-ol-17-one (dehydroepiandrosterone, DHEA) in the diet of rats induced the synthesis of liver mitochondrial sn-glycerol 3-phosphate dehydrogenase to levels three to five times that of control rats within 7 days. The previously reported enhancement of liver cytosolic malic enzyme was confirmed. The induction of both enzymes was detectable at 0.01% DHEA in the diet, reached plateau stimulation at 0.1 to 0.2%, and was completely blocked by simultaneous treatment with actinomycin D. Feeding DHEA caused smaller, but statistically significant increases of liver cytosolic lactate, sn-glycerol 3-phosphate, and isocitrate (NADP(+)-linked) dehydrogenases but not of malate or glucose 6-phosphate dehydrogenases. The capability of DHEA to enhance mitochondrial glycerophosphate dehydrogenase and malic enzyme was influenced by the thyroid status of the rats; was smallest in thyroidectomized rats and highest in rats treated with triiodothyronine. 5-Androsten-3 beta,17 beta-diol and 5-androsten-3 beta-ol-7,17-dione were as effective as DHEA in enhancing the liver mitochondrial glycerophosphate dehydrogenase and malic enzyme. Administering compounds that induce the formation of cytochrome P450 enzymes enhanced liver malic enzyme activity but not that of mitochondrial glycerophosphate dehydrogenase. Arochlor 1254 and 3-methylcholanthrene also increased the response of malic enzyme to DHEA feeding.

Animals↗