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C Z Gomez

Publications and source records attributed to C Z Gomez.

14 recordsLinked to original sources
PubMed1978

A controlled field trial of plain and aluminium hydroxide-adsorbed cholera vaccines in Surabaya, Indonesia, during 1973--75.

A controlled field trial comparing the effectiveness of a plain cholera vaccine with that of a vaccine adsorbed to aluminium hydroxide was carried out in a cholera-endemic area of Indonesia during 1973-75. Tetanus toxoid adsorbed to aluminium phosphate was used as the control. In vaccinees aged 1-4 years, the adsorbed cholera vaccine provided about 88% protection for 6 months following vaccination and still provided about 50% protection between 11 and 14 months after vaccination. In the same age group, the plain vaccine provided only 53% protection during the first 6 months and no appreciable protection beyond that period. In those aged 5 years and over, both vaccines provided 50-60% protection throughout the period of observation (14 months). Neither vaccine caused any serious side effects.

Adjuvants, Immunologic↗
PubMed1967

A controlled field trial of the effectiveness of cholera and cholera El Tor vaccines in the Philippines.

A controlled field trial on some 584 000 people in an endemic cholera El Tor area in the Philippines demonstrated that cholera vaccines gave moderate protection of short duration. Injection of a single dose of vaccine prepared from either Vibrio cholerae or El Tor vibrios gave over 50% protection for the first 2 months. The immunity conferred by the V. cholerae vaccine declined rapidly after 3 to 4 months. The effectiveness of the El Tor vaccine continued for 6 months. An oil-adjuvant vaccine prepared from V. cholerae conferred an equally high degree of protection for a longer period of time, but, owing to severe vaccination reactions, its use could not be recommended.

Adjuvants, Immunologic↗
PubMed1967

Studies on cholera carriers.

Cholera carrier studies in the Philippines in 1964-66 showed a prevalence rate of 21.7% among household contacts of cholera patients, and 8.4% in occupants of houses next door to one where a cholera patient lived, as opposed to 0.34% in the general population. The duration of the carrier state among 19 household carriers isolated for examination varied from 5 to 19 days. The vibrio concentration in the stool of contact carriers was 10(2)-15(5) per gram, as compared with 10(6)-19(9) per ml of rice-water stool in cholera cases.The agglutinin titre increased with time for carriers, as it does for patients. It declined to a very low level 8-12 weeks after recovery, with the exception of one proved long-term carrier.The strains isolated from carriers were identical in all respects, including virulence in infant rabbits, with strains isolated from patients-except that 3 carrier strains were rough.

Adolescent↗
PubMed1967

A long-term carrier of cholera: cholera Dolores.

The first known long-term carrier of cholera, found in the Philippines, is described. The carrier, Dolores M., who had suffered from El Tor cholera in August 1962, continued intermittently to excrete vibrios of the same characteristics as the original isolates until the date of reporting (1966). Duodenal intubation proved that the vibrios are lodged in her biliary tract. Her serum antibody titre continued to remain high in the absence of vaccination against cholera.

Biliary Tract↗
PubMed1965

Studies of cholera El Tor in the Philippines. 3. Transmission of infection among household contacts of cholera patients.

As part of a broad epidemiological investigation of cholera El Tor in the Philippines, the authors cultured rectal swabs obtained from the household contacts of cholera patients hospitalized in the Negros Occidental Provincial Hospital from August through October 1962. Additional infected persons were found in 25 (60%) of the 42 households with confirmed cases and in 55 (18%) of 302 household contacts of confirmed patients. Since only five of the 55 infected household contacts developed illness severe enough to require hospitalization, it was apparent that those with severe illness accounted for but a small proportion of the total infections. Asymptomatic infections were rarely found outside the households with proven cases, suggesting that close person-to-person contact was necessary for the spread of infection. Asymptomatic carriers as well as symptomatic patients appeared to play significant roles in the transmission of infection.

Adolescent↗
PubMed1965

Studies of cholera El Tor in the Philippines. 4. Transmission of infection among neighbourhood and community contacts of cholera patients.

As part of a broad study on the epidemiology of cholera El Tor in the Philippines, the authors conducted bacteriological surveys among the community contacts of suspect cholera patients hospitalized in the Negros Occidental Provincial Hospital from August through October 1962. Fourteen (2%) of 698 community contacts of persons with confirmed cholera patients were found on initial culture to be infected.Intensive studies in two communities suggested that infection was spread primarily by close personal contact; in a third community, contamined well-water presumably served as a vehicle for the transmission of infection. Diagnosed and undiagnosed cases, undiagnosed cholera deaths and asymptomatic infections all played a role in cholera transmission.The studies tend to confirm that the second or recurrent epidemic in Negros Occidental was primarily caused by person-to-person spread. Although the seemingly isolated or sporadic cases were sometimes associated with a more general distribution of the cholera vibrio, the cholera infections invariably were highly localized among close contacts even within densely populated areas with poor sanitation.

Adult↗