PubMed Health⌕ Search

Biomedical subjects

C Zimmermann-Nielsen

Publications and source records attributed to C Zimmermann-Nielsen.

10 recordsLinked to original sources
PubMed1994

Activity and activation of the complement system in patients being operated on for cancer of the colon.

OBJECTIVE: To find out if there was any local activation of complement in the vicinity of a colonic cancer, and any fluctuation in the function of the complement system during operation. DESIGN: Prospective study. SETTING: One university and two district hospitals in Denmark. SUBJECTS: 29 selected patients undergoing emergency and elective operations for colonic cancer. INTERVENTIONS: Measurements of systemic and local complement fixation capacity and complement activation in samples of serum or plasma taken before, during, and after operation. MAIN OUTCOME MEASURES: Changes in complement fixation capacity and complement activation during operation. RESULTS: Haemodilution during operation caused a significant reduction in the complement fixation capacity of serum and in the activation of the complement system as measured by generation of C3c. We were unable to confirm the presence of complement inhibitors during operation. Haemodilution caused a 30% reduction in fixation capacity of C3b (12/29 samples of serum had values more than 2SD below the mean of the reference range compared with 4/29 before operation). The activity of C4 was reduced by 25% during operation and the capacity of the complement system to fix C3b and C4b was restored to baseline nine days postoperatively. Concentration of C3d was significantly higher in serum from tumour venous blood compared with that from peripheral blood during operation. CONCLUSION: The presence of complement activation products in the general circulation reflects local activation of the complement system in the vicinity of the tumour, but this may have been influenced by tissue necrosis or subclinical infection. Haemodilution causes a significant reduction in the capacity of the complement system during operation, whereas inhibitory factors associated with the cancer or operation and anaesthesia could not be demonstrated. We found no correlation between complement activity and clinical data.

Adult↗
PubMed1985

Chronic pilonidal disease: a randomized trial with a complete 3-year follow-up.

Three treatments for chronic pilonidal disease were compared in a randomized trial. Healing without formation of new sinuses occurred equally frequent after excision (E), excision with suture (E + S) and excision with suture under cover with clindamycin (E + S + C). The times of healing were significantly shorter after E + S (median 14 days, n = 29) than after E (64 days, n = 29) and tended to be even shorter after E + S + C (11 days, n = 30). Recurrence rates within 3 years amounted to 13 per cent after E, 25 per cent after E + S and 19 per cent after E + S + C, but the total time of healing after initial surgery as well as excision of recurrences was significantly shorter after E + S than after E and tended to be even shorter after E + S + C.

Adolescent↗
PubMed1976

Comparison of Dexon and Mersilene sutures in the closure of primary laparotomy incisions.

The study is a comparison of Dexon (polyglycolic acid) and Mersilene (polyester) sutures when employed for the primary closure of the peritoneum and aponeurotic layer in primary laparotomy incisions. The material comprises 308 closures of abdominal wounds with interrupted 2-0 sutures (United States Pharmacopeia) in the aponeurosis and continuous 2-0 suture of the peritoneum. One half of the wound was closed with Dexon and the other half with Mersilene, so that the patient acted as his own control. No significant difference was found between the two materials as evaluated from the occurrence of wound rupture within 10 days and incisional hernia within 90 days of the operation. Suture granulomas occurred in 9% of the half wounds sutured with Mersilene. The present clinical investigation demonstrates that Dexon sutures are as reliable as unabsorbable material. Dexon is superior to unabsorbable material as suture granulomas were not seen when Dexon was employed.

Adolescent↗
PubMed1975

Evaluation of peroperative cholangiography during cholecystectomy.

In a retrospective investigation comprising 219 choledochotomies, of which 57 were explorative (26%), and 162 were choledocholithotomies (74%), an attempt has been made to evaluate the indications for exploration of the common duct and the diagnostic reliability of post-explorative cholangiography. Retrospectively, we find that explorative choledochotomy was justified in 40 out of 57 cases, unless the risk of overlooking stones in the bile ducts was to be increased. In the remainder of the cases (17/57) it was a question of either misinterpretation or of non-evaluable cholangiograms. A diagnostic reliability of 93.6% was obtained at post-explorative cholangiography, making incidence of residual stones at postoperative cholangiography 6.4%. The errors were due to either technically poor cholangiograms (4/14) or misinterpretations (10/14). The conclusion is that peroperative cholangiography is a most important aid in diagnosing stones in the bile ducts before as well after choledochotomy, but that the results presumably to some extent can be improved by using radiological expertise.

Cholangiography↗