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Biomedical subjects

C Zippel

Publications and source records attributed to C Zippel.

At least 19 recordsLinked to original sources
PubMed1987

[Rehabilitation in cerebrovascular stroke--experiences and results of a treatment concept based on modern neurophysiology knowledge].

The modern concept of rehabilitation of patients with stroke is based on new neurophysiological investigations about processes of movements, learning and memory. Therefore the rehabilitation is multidimensional. The complete patterns of symptoms must be considered. The training of cognitive functions has the same importance as the treatment of disorders of movements. The effects of this concept are investigated in 295 patients in accordance with self-activities and ability of walking. The results have been compared with 101 patients without consideration of all gnostic defects. The results of the modern rehabilitation concept were better. Patients with aphasia having similar good results but patients with diminished ability to cooperation having unfavourable prognosis of rehabilitation.

Activities of Daily Living↗
PubMed1985

[Cytomegalovirus infections after kidney transplantation and passive immunization].

Cytomegalovirus infection after renal transplantation impairs the survival rate of patient and graft. An incidence of 24 to 92% of CMV infections after renal transplantation is reported, but only 15 to 77% of these patients show clinical symptoms. Contaminated donor organs, blood transfusions and reactivation by immunosuppression are the main causes of this infection. Active immunisation cannot prevent the reactivation of the infection, but also antiviral agents can hardly influence the course of the disease. Passive immunisation showed promising effects in bone-marrow transplantation and is now also tried in renal transplantation. The first results of a randomized study do not allow a final conclusion, but show less clinical symptomatic CMV infections, and statistically significant less herpes simplex infections in the group receiving anti CMV IgG prophylaxis.

Antibodies, Viral↗
PubMed1985

[Segmental chlamydia proctitis].

A case report is given of a 28 year old homosexual suffering from segmental proctitis caused by Chlamydia. The patient had watery diarrhea and fever since 3 weeks. Stool specimen testing was negative in regard to Salmonella, Shigella and worm eggs. Infection with N. gonorrhoea, Herpes simplex virus, Toxoplasma gondi, Yersinia and M. tuberculosis could be excluded. Serological testing yielded results suggestive of an old lues infection successfully treated. On histological examination typical reticulocytary suppurating granuloma were found. Therapy of choice of Chlamydia-proctitis is tetracyclines.

Adult↗
PubMed1984

[Prognosis and epidemiology of acute hepatitis B infection].

44 patients with acute hepatitis B virus (HBV) infection were observed until recovery and formation of anti-HBs or in case of development of chronic infection for up to 18 months. With the exception of 3 patients the infection resolved clinically within 3 to 16 weeks, HBs and HBe antigen were eliminated. Anti-HBs and anti-HBe formation could be demonstrated in 39 patients. An accurate prognosis of the course of the disease could be predicted in 42 out of 43 patients by comparison of the serum HBs antigen concentrations at the beginning of clinical symptoms with those after 4 weeks. Inclusion of HBe antigen demonstration enabled predictability in all patients. In 15 patients with acute HBV infection the risk of infection (occupational exposure, transfusion etc.) was known. By investigation of contact persons (family members, sex partners etc.) of the remaining patients HBs antigen und partly HBe antigen in serum could be demonstrated in 11.8% of these persons (11 out of 93). In contrast, in contact persons of patients with known risk of infection HBs antigen could be demonstrated in only one case (1 out of 36). No one of the HBs antigen positive contact persons was aware of the possibility of infectiousness. They did not perceive any connection between their own chronic infection and acute HBV infection occurring around them.

Hepatitis B↗
PubMed1983

Comparison of four different methods for detection of rubella IgM antibodies.

Four different tests for detection of rubella-specific IgM antibodies were compared: two Ig separation methods (centrifugation and chromatography) with subsequent haemagglutination inhibition test and two commercially available ELISA tests. The 114 sera tested had been sent to the diagnostic laboratory, mostly with insufficient clinical histories. Agreement between the centrifugation method and one of the ELISA tests was good (2 divergent results with 107 sera tested), while the other ELISA test yielded more positive (partly perhaps non-specific) results. The chromatographic method did not separate the Ig classes as reliably as the centrifugation method, but because of its simplicity it may be useful, if adequate test controls are performed. The divergent results are discussed. It is postulated that in cases with pending induced abortion, two independent tests should be performed.

Antibodies, Viral↗
PubMed1982

Demonstration of rubella-specific IgM by serum ultracentrifugation on sucrose gradients: comparison of a vertical and a swinging bucket rotor.

The performances of a vertical and a swinging bucket rotor in the diagnosis of rubella-specific IgM were compared using two sets of predominantly low titre rubella IgM positive sera. Applying a number of subtle criteria, the vertical rotor was shown to separate IgM and IgG less well than the swinging bucket rotor. If the vertical rotor was loaded with pretreated sera with IgG content decreased severalfold, its performance was similar to that of the swinging bucket rotor with native serum. The findings are discussed from the aspect of the main indication of rubella IgM testing, and it was concluded that for the majority of cases the vertical rotor would not present an alternative to the swinging bucket rotor.

Antibodies, Viral↗
PubMed1982

Peripheral facial palsy and infections- findings and problems.

Eighty-four patients of the Cologne University ENT Clinic with a diagnosis of idiopathic peripheral facial palsy (PEP) were examined - both clinically and virologically. In addition, examinations were carried out on 33 further PFP-patients from different practising physicians (Group B) where the clinical information, however, was much less detailed. In the ENT Clinical Group (84 patients), there was a total of 12 recent virus infections (9 varicella zoster virus, 2 herpes simplex virus, 1 coxsackie B4). Proof of a recent infection depended strongly on the diagnostic prerequisites: if early and paired sera were available a virological diagnosis was possible in 32% of the cases, while in some of the other patients a recent infection could at most be suspected by the serological results. Group B with the 33 unselected patients yielded no virologically significant results. The aetiological relationship between the virological findings and PEP is discussed.

Adolescent↗
PubMed1982

[HBs-antigen determination during pregnancy with reference to prevention of a postnatal infection in the newborn infant].

In 1980 and 1981 the blood samples of 2040 pregnant women from the Department of Obstetrics of the University Hospital of Cologne have been examined for HBs-antigen. In 37 samples (1.8%) HBs-antigen was detected. As there are considerable racial as well as geographic differences in the frequency of HBs-antigenemia, we differentiated between German and foreign women. In 10 out of 1519 (0.7%) German and in 27 out of 521 (5.2%) foreign women, respectively, HBs-antigen could be demonstrated. Only 1 woman was known to be HBs-antigen positive. Until now, 38 children have been born in the University Hospital to 33 HBs-antigen-positive mothers. After birth, 35 children received hepatitis B immune globulin (HBIG). So far, none of these immunised children exhibited signs of a hepatitis B infection--22 children have been followed up 5-19 months, and 13 children 1-4 months. Three newborns did not receive HBIG: One child was already infected at time of birth, the 2 other children were erroneously not given HBIG. One of these 2 children fell ill at the age of 5 months with clinical and serological manifestations of hepatitis B, the other child appears healthy up to date (11 weeks).

Ethnicity↗
PubMed1982

[Selective and controlled mass rubella vaccination - experiences with an economical method (author's transl)].

Immunity to rubella virus was examined in blood samples of 5870 school girls. Only in 22.7% of the girls a vaccination proved necessary. HDC vaccine (strain RA 27/3) was used. By postvaccinal control successful vaccination could be demonstrated in 99.6% of the vaccinated girls. The hemolysis in gel test (HIG) (3557 samples) and an enzyme-linked immunosorbent assay (ELISA) (1134 samples) were compared with the hemagglutination inhibition test (HI) as to their reliability and sensitivity in demonstrating rubella virus antibodies. HIG and HI exhibited identical results, whereas with the ELISA diverging results were obtained in 14% of the samples. 30 girls being antibody-positive only in the ELISA were vaccinated. Only 28 of these girls developed rubella specific IgM-antibodies after vaccination. This results strongly suggests that at least in these 28 prevaccinal samples the ELISA yielded false positive results.

Adolescent↗
PubMed1980

[Quantitative determination of rubella virus antibodies in capillary blood. A simple, reliable and economic method (author's transl)].

In order to carry out a serological control for rubella mass vaccination with the least possible organization and financial expense a study was made to see whether the more economical hemolysis in gel test (HIG) achieved comparable results to the hemagglutination inhibition test (HHT) and whether the reliability of investigation of capillary blood corresponded to that of venous blood. The prevaccination immunity of 935 schoolgirls was tested with the HHT and HIG tests with venous and capillary blood. The results of the HIG test with both venous and capillary blood were equal in all 935 cases, so that the investigation of capillary blood is suitable for the determination of rubella specific antibodies.

Antibodies, Viral↗