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Biomedical subjects

C Zychowicz

Publications and source records attributed to C Zychowicz.

At least 19 recordsLinked to original sources
PubMed1996

[Vaccination and intensified sanitary regime for prevention of viral hepatitis type B among medical personnel at the Center for Health of the Child].

Paper concerns the question of infections by hepatitis B virus among health care workers. Authors have reported the improvement of epidemiological situation among employees of the Child Health Center in the years 1987-1994 and analysed factors which were the probably cause of improvement (protective vaccination, infection control, and education of workers). In the first year of observation, among ca. 1700 health care workers 32 new hepatitis B infections were noted, while in 1994 there were no hepatitis B cases.

Adult↗
PubMed1995

Immunological and genetic studies on hereditary angioedema.

Ca. eighty patients with hereditary angioedema due to C1-inhibitor deficiency were diagnosed and treated in Poland during last the 15 yrs, mainly in centers from Warsaw, Cracow and Bydgoszcz. The detailed description concerns 17 patients, 14 females (82%) and 3 males (18%). Important diagnostic points, response to treatment, and critical serum values of C1-inhibitor were evaluated. In the experimental part, we have established fibroblasts cell lines from 5 patients with type I HAE, with characteristic profound deficits of C1-INH (antigenic and functional) and C4. Fibroblasts from all the patients synthesized only ca. 20% of the normal values of C1-INH. We have confirmed the data from other authors that C1-INH synthesis can be substantially increased (11 to 20-fold) by IFN-gamma at a pretranslational level.

Adult↗
PubMed1993

[The problem of allergic pulmonary aspergillosis in children in light of personal observations].

67 children (age range 4-17 years) with severe asthma were examined for the presence of allergic pulmonary aspergillosis 28 of these underwent long term steroid therapy. The following parameters were analysed: medical history, clinical state, chest radiograms, microbiological examination of the sputum, precipitating IgG antibodies, skin prick tests with aspergillus, level of specific IgE antibodies. The authors did not find any single child that met the diagnostical criteria of allergic pulmonary aspergillosis. Only in 4 serum specific IgE antibodies were found but the precipitin and skin prick tests were negative. The children did not present typical clinical symptoms of pulmonary allergic aspergillosis. It seems worthwhile to re-examine these children in a few years.

Adolescent↗
PubMed1991

Effect of salbutamol on specific airway resistance in infants with a history of wheezing.

The purpose of this study was to assess the effectiveness of nebulized salbutamol in infants with a history of wheezing. Eighty-eight children aged 3-24 months with a history of wheezing were studied, in seven groups: I (n = 15) and I/A (n = 17) with elevated specific airway resistance (SRaw); II (n = 17) with normal SRaw; III (n = 23), III/A (n = 17), and IV (n = 18) with normal SRaw exposed to carbachol bronchial challenge (CBC); and V (n = 13) serving as control. Infants for groups I/A and III/A were selected to match by age and by baseline and post-carbachol SRaw values, respectively. Baseline airway resistance and thoracic gas volume (TGV) were measured plethysmographically. Specific airway resistance was selected as an index of bronchial function. Thereafter every child in groups I, I/A and II inhaled 200 micrograms of salbutamol by tidal breathing, and the children in groups III, III/A, and IV were exposed to CBC. Following positive reaction to carbachol, children of groups III and III/A inhaled salbutamol (200 micrograms, tidal breathing), and those of group IV received no drug. Controls from group V with normal SRaw received placebo (phosphate-buffered saline). Plethysmography was repeated in all children at 5 minute intervals. Following salbutamol SRaw was reduced in children with elevated and normal SRaw. In contrast, children not receiving salbutamol had unchanged SRaw value. The response to salbutamol measured by SRaw, Raw, and TGV was not significantly different in the spontaneously obstructed infants compared to those who received carbachol. In conclusion, infants with a history of wheezing do respond to inhaled salbutamol.

Airway Resistance↗
PubMed1989

[Hormonal inhalation preparations in the treatment of bronchial asthma in children].

Hormonal inhalation preparations (Becotide, Beclomet) were given to 59 children aged 3 to 18 years with severe and long-standing asthma. In most cases (70% a striking improvement of the general condition was achieved with complete regression or alleviation of dyspnoeic attacks. In 15 out of 17 children prednisone could have been withdrawn. No side effects were noted. In 4 children administration of Becotide or Beclomet was not possible.

Administration, Inhalation↗
PubMed1989

[Functional status of the bronchial tree in infants with gastroesophageal reflux].

Airway resistance (Raw) and functional residual capacity (FRC pl) were determined by plethysmography in 17 children aged 3 to 12 months. Gastroesophageal reflux was diagnosed on the ground of longterm monitoring of esophageal pH or the X-ray examination of the stomach. No elevated airway resistance was found. In 41% of the cases FRC (per kg of body weight) was increased. This indirectly indicates the diminished small airways patency.

Airway Resistance↗