[Hemodyalisis as therapy of choice in lactic acidosis associated with metformin].
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Biomedical subjects
Publications and source records attributed to C de Ancos Aracil.
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The HACEK group endocarditis are infrequent in general population. They usually develop subacute endocarditis with large vegetations, peripheral emboli, heart failure, requiring frequent valvular replacement. We report a clinical case of endocarditis caused by Actinobacillus actinomycetemcomitans (AA), without the typical findings of the HACEK group endocarditis and with a successful evolution with medical treatment.
Despite the availability of an effective treatment for most cases, tuberculosis (TB) is still a cause of death in our environment. The necropsic sections of patients died because of TB during the 1987-1996 period at Hospital Clínico de San Carlos, Madrid, were reviewed. The investigated data from each patient included age, gender, chronology of suggestive symptoms of TB, degree of histological involvement, radiological pattern in chest X-ray, delay in initiating therapy, concomitant diseases and other alternative diagnosed considered. The delay in diagnosis was the main cause for TB mortality. Advanced age, delay in seeking medical care and the presence of atypical clinical and radiological patterns contributed to the fatal end. Other factors included alcoholism and immunodeficiency.
BACKGROUND: Ischaemic colitis represents the most common form of intestinal ischaemia and involves more commonly elderly patients with a variety of underlying conditions. This study analyses the epidemiology and clinical characteristics of the disease in our environment. PATIENTS AND METHODS: The IC cases occurred at our institution during the last two years were studied. Twenty-eight cases of IC obtained by reviewing colonoscopy and pathological records were analyzed. RESULTS: The non-occlusive type is the most common presentation form of IC. It affected elderly patients (74 +/- 10 years) with cardiovascular risk factors. Most cases manifested with abdominal pain (68%). In 64% cases, colonoscopy showed ulcerations, located mainly at descending colon and rectosigmoid. The clinical course was generally favourable with conservative measures. The overall mortality rate was 10%. CONCLUSION: The possibility of IC should be considered in the differential diagnosis of elderly patient with abdominal pain and cardiovascular risk factors.
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The microscopic polyarteritis is a vasculitis related to necrotizing glomerolunephritis. It always damages at renal and systemic level (a third of the cases presented hemorrhage alveolar). We have showed a case that took place with hemoptysis and renal progressive insufficiency. Among the patient antecedents, we can find arterial hypertension hematuria, rhinitis, epistaxis and artromyalgias. Just before his admittance it showed edemas on lower limbs and eyelids, dysnea, severe hemoptysis, paresthesias and general malaise. The immunologic analysis: Acs. glomerular basal antimembrane: negative, ANCA positive with antimieloperoxidasa specificity. The renal biopsy: focal necrotizing glomerulonephritis with semilunar and negative immunofluorescent. The nasas biopsy: unspecified chronic rhinitis. From the clinic point of view, the patient seemed to have the Wegener granulomatosis apart from the fact that he had hemoptysis which is a rare sign in this cases. However, we could not find any granuloma anatomopatologically, which did not clarify this diagnosis. We diagnosed microscopis Poliarteritis, as a third of the cases presented intrapulmonary haemorrhage. Moreover the renal damage it is identical than in the in Wegener granulomatosis. On the top of that, often we can find p-ANCA, which confirms the diagnosis in 99% of cases. Despite our doubt according to the diagnosis the therapeutical treatment of both illnesses is nowadays identical. This means that we were able to begin a precocious treatment with plasmapheresis, metilprednisolona and ciclofosfamida. After a week treatment there was an evident improvement. Five moth later the illness relapsed.
Microscopic polyarteritis is a type of vasculitis that shows similar characteristics to other illnesses from the same group. This group presents a common clinical fact: a rapidly progressive glomerulonephritis. We specially point out among this group of illnesses the Wegener granulomatosis. The anti-neutrophil cytoplasmic antibodies is important for two different reasons. The fact that sometimes they have allowed to make differential diagnosis and that they represents so far the only serologic marking of such vasculitis. The ANCA antimieloperoxidasa (p-ANCA) can be found in a greater level in microscopic poliarteritis as well as the antiproteinasa-3 (c-ANCA) in the Wegener granulomatosis. The current revision tries to clarify the differential diagnosis of the microscopic poliarteritis, which nowadays is still quite vague. This lack can be compensated thanks to the fact that the therapeutic treatment of this group of illnesses is very similar.