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C de Castellarnau

Publications and source records attributed to C de Castellarnau.

29 records · Page 2Linked to original sources
PubMed1987

Effects of ticlopidine on metastasis production in mice bearing Lewis lung carcinoma.

Ticlopidine has been shown to markedly inhibit the platelet aggregability induced by ADP in control animals not receiving 3LL cells. Ticlopidine was administered orally at the selected dose (200 mg/kg/day), to the rodents using different dose schedules and the inhibitory effects on spontaneous lung metastases of the Lewis lung carcinoma were studied. Ticlopidine did not have any significant influence on the metastases formation and on the primary growth of 3LL, although it inhibited platelet aggregation in tumor-bearing mice. These data indicate that the antiaggregatory effects of ticlopidine are not related to an antimetastasic effect in our model.

Animals↗
PubMed1981

Salicylate-aspirin interaction in the rat. Evidence that salicylate accumulating during aspirin administration may protect vascular prostacyclin from aspirin-induced inhibition.

Aspirin inhibits cyclooxygenase, thus preventing thromboxane A2 production in blood platelets and prostacyclin in vascular cells. Aspirin is rapidly hydrolyzed to salicylate in the circulation. The objectives of this study were (a) to evaluate whether administration of salicylate, though ineffective by itself, prevents the inhibitory effect of aspirin on platelet and/or vascular cyclooxygenase activity; (b) to verify whether salicylate accumulating in blood after aspirin administration interferes with the pharmacological activity of further doses of aspirin. Pretreatment of rats with sodium salicylate (25-100 mg/kg i.p.) resulted in dose-related prevention of the effect of a subsequent dose of aspirin (2.5-10 mg/kg i.v.) on both platelet and vascular cells. Sodium salicylate appeared to amplify the greater response of platelets to aspirin compared with vessel wall. Pretreatment of rats with repeated high doses of aspirin (200 mg/kg) resulted after 24 h in blood salicylate levels (150-200 microgram/ml) that significantly prevented the inhibitory effect of a subsequent dose of aspirin on newly synthesized vascular prostacyclin. Blood salicylate levels obtained after 36 or 48 h (less than 50 microgram/ml) were too low to blunt aspirin's effect. The interference with aspirin of its major endogenous metabolite should be borne in mind when interpreting results obtained with high dose aspirin or during repeated administration of this drug.

Animals↗
PubMed1979

Effect of ethanol on glucose and tyrosine transport in the rat small intestine.

The effect of ethanol on the intestinal absorption of glucose and tyrosine in the rat small intestine has been studied. Ethanol inhibits the active transport of these substrates both in incubation and preincubation experiments. Ethanol, besides, increases diffusion of arabinose, which may indicate an unspecific alteration of intestinal permeability.

Animals↗
PubMed1979

Oxyphenisatin derivatives and intestinal glucose and tyrosine absorption.

The effect of oxyphenisatin and three other isatin derivatives on glucose and tyrosine absorption is studied in rat small intestine, in vitro. Compounds with free phenolic groups elicit, even at low concentrations, strong inhibition on active transport, while those with the sulfate-esterified phenolic groups show no effect whatsoever. One minute preincubation with 10(-7) M oxyphenisatin is enough to inhibit sugar absorption completely.

Glucose↗