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Biomedical subjects

C de Micco

Publications and source records attributed to C de Micco.

29 records · Page 2Linked to original sources
PubMed1984

Laboratory diagnosis of Mediterranean spotted fever by immunofluorescent demonstration of Rickettsia conorii in cutaneous lesions.

Indirect immunofluorescent staining was performed on cryostat sections of skin biopsy specimens from 21 patients. In six of the 11 cases finally diagnosed as Mediterranean spotted fever, coccobacillary forms of Rickettsia conorii were identified in these sections. A factor recognized as contributing to false-negative results was prior treatment with tetracycline. No false-positive results were obtained for 10 patients whose final diagnosis was not Mediterranean spotted fever. This laboratory test can aid in the early diagnosis of severe and atypical forms of Mediterranean spotted fever.

Adolescent↗
PubMed1980

[Comparative induction of viral antigen synthesis in various types of cells infected by polyoma virus].

Induction of synthesis of the viral antigens T and V during polyoma virus infection was studied in primary Mouse and Hamster kidney and brain cultures, as well as in various types of human cells. The results show that: (1) Despite a very low percentage of positive cells by immunofluorescence, Hamster brain cells produced more viral antigen than kidney cells, as opposed to what was found in Mouse brain cells. (2) Most human cells produced neither T nor V antigens. Conversely, a large number of brain cells synthesized the T antigen very early after infection.

Animals↗
PubMed1979

Tumorigenic clones of hamster brain cells transformed in vitro by polyoma virus. Ultrastructural and immunohistochemical study.

The morphological characteristics of three clones of hamster brain cells transformed in vitro by polyoma virus and of the tumors obtained after subcutaneous grafting of these cells in syngenic animals are reported. These clones appeared to be glial in nature by light and electron microscopy. The initial tumors induced by the three clones presented astrocytic features both by electron microscopy and immunohistochemistry. Analysis of the subsequent in vivo passages showed a decrease in cell differentiation, which was accompanied by a decrease in the latency period; after 2 years of serial transplantation, the tumors seemed poorly differentiated gliomas. A control cell line of hamster cerebellar cells evolved similarly.

Animals↗
PubMed1978

Neoplastic transformation of hamster brain cells in vitro by polyoma virus.

The transformation of cultivated hamster brain cells by polyoma virus is reported. The transformed cell line contained polyoma virus-specific nuclear, surface and transplantation antigens. Subcutaneous and intracranial inoculations revealed high tumorigenicity of the cells. Brain-specific S 100 protein was found in these tumors with immuno-peroxidase staining, suggesting that they were of a nervous nature. Both in vivo and in vitro, the cells had glial features as studied by phase contrast, light and electron microscopy. Type-H virus-like particles were found in the tumor cells and might have played a role in the viral transformation.

Animals↗
PubMedDate not supplied

[Exudative enteropathy caused by clofazimine: apropos of a case].

The authors report a case of a forty-six year old woman suffering from generalized prurigo nodularis. This dermatosis was associated with a cellular immunodeficiency; therefore a clofazimine therapy 300 mg/a day was instituted for six months. Ten months after the cessation of the clofazimine therapy, there appeared a malabsorption syndrome that was temporarily improved by gluten--free diet the real etiology was only ascertained during laparotomy, when masses of crystals in the small intestine mucosa as well as in mesenteric lymph nodes were observed. Therefore when it is necessary to prescribe clofazimine to take advantage of become its immunoregulating properties, it must always become in mind that an intestinal complication may ensue: this is well recognized in articles appearing in journals devoted to leprosy.

Clofazimine↗