Identification of a novel human leukocyte antigen-B allele, B*4048, in Taiwan.
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Alleles↗
Biomedical subjects
C-C Chu
Publications and source records attributed to C-C Chu.
A*1126: a novel HLA-A11 variant identified by sequence-based typing method.
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Alleles↗
A novel HLA-B allele, B*5612, identified by sequence-based typing method.
HLA-B*5612, found in Taiwan using sequence-based typing method, was identical to HLA-B*5502 in exon 2 but differed in exon 3 by 10 nucleotide substitutions at positions 353-420 leading to five amino acid change at codon 94, 95, 97, 103 and 116. As this sequence motif was not found in the Asian population, it is likely that HLA-B*5612 is the product of a complex mechanism of implying a dual gene conversion event.
Base Sequence↗
Acute painful neuropathy in thallium poisoning.
Dysesthesia, allodynia, distal muscle weakness, and sensory impairment were noted in two patients with acute thallium intoxication. Two months later, nerve conduction studies showed an axonal degeneration. Sural nerve biopsy disclosed a decreased fiber density in the large myelinated fibers. Quantitative sensory testing also revealed an impairment of pinprick, temperature, and touch sensations. Cutaneous nerve biopsy confirmed a loss of epidermal nerves indicating an involvement of the small sensory nerves.
Acute Disease↗
Identification of two novel HLA-DRB1 alleles, DRB1*0903 and DRB1*1145.
Two new HLA-DRB1 alleles were identified by sequencing-based typing in the oral submucous fibrosis and buccal cancer patients of Taiwan. They have been officially named HLA-DRB1*0903 and DRB1*1145 by the World Health Organization Nomenclature Committee. The complete exon 2 sequence of DRB1*0903 was identical to that of the DRB1*090102 but differed by nucleotides of position 207-210 and 216 (AGAC, C replacing GCGG, and G). The DRB1*1145 was identical to the DRB1*110101 except for three nucleotide substitutions at codon 199, 220, and 221 (A, CT replacing T, and GC). Two complete exon 2 sequences of those new alleles had been deposited in the EMBL Sequence Database under accession number AY465114 and AY465115, respectively.
Alleles↗