Biomedical subjects

Cai-lian Zhu

Publications and source records attributed to Cai-lian Zhu.

3 recordsLinked to original sources

PubMed2006

[Inhibition of extracts from 17 Chinese herbs on periodontal pathogenic microbes].

PURPOSE: To evaluate the efficiency of 17 Chinese herbs on periodontal pathogenic microbes. METHODS: 17 efficient substances from Chinese herbs were purchased from Chinese Drug Identification Bureau, including magnesium lithospermate B, magnolol, tetramethyl pyrazine, matrine, dycyrrhizin, gentiopicrin, aloperin, baicalin, oleanolic acid, ginkgo seed, total glucosides of paeony capsules, anisldehyde, archin, cablin patchouli, hydrochloric acid Berberine, forsythin, and kakonein. Antimicrobial sensitivity tests of broth microdilution methods on 96-microwell plate were carried out for identification of the antimicrobial activity of extracts against six species of microorganisms: Actinobacillus actinomycete mitans(Aa) Y4, Actinomycetes viscosus(Av) 19246, Porphyromonas gingivalis(Pg) 33277, Fusobacterium necrophorum(Fn) 25286, Actinomyces naeslundii(An) wvl 45 and Prevotella nigrescens(Pn). RESULTS: It was found that magnesium lithospermate B and magnolol showed the most efficient inhibition on microorganism of Pn and Fn, with the MIC being 0.053 and 0.313 mg/ml for Pn and Fn, respectively. Tetramethyl pyrazine, matrine, dycyrrhizin, gentiopicrin, aloperin, baicalin, and oleanolic acid had better inhibition than total glucosides of paeony capsules, anisldehyde, archin, cablin patchouli, hydrochloric acid berberine, forsythin, and kakonein. CONCLUSION: The Chinese herbs, magnesium lithospermate B and magnolol are efficient agents for inhibition against periodontal pathogenic microbes.

Actinomyces↗

PubMed2003

[A comparative study of root smear layer removal using different pH EDTA salts].

OBJECTIVE: To evaluate the effect of different pH EDTA salts on removing root canal smear layers. METHODS: Sixty human teeth with single root were instrumented using step-back technique, then were irrigated with several irrigating solutions including A: 0.9% saline; B: 5.25% NaOCl +3% H2O2; C: 15% EDTA (pH = 6.5); D: 15% EDTA (pH = 13); E: 15% EDTA (pH = 6.5) 25% NaOCl +3% H2O2; F: 15% EDTA (pH = 13) 25% NaOCl +3% H2O2. After the teeth were split, the root canal walls were examined with scanning electron microscopy at the coronal, middle and apical thirds for smear layer removal. RESULTS: Except A and B group, all the groups were effective on removing smear layer at the coronal, middle thirds of the root canal, group C had a stronger effect to remove smear layer than group D (P < 0.05), group E was the most effective among these groups. However, these groups were all ineffective on removing smear layer at the apical thirds of root canal. CONCLUSIONS: 15% EDTA (pH = 6.5) 25% NaOCl +3% H2O2 was the most effective irrigation on removing smear layer.

Edetic Acid↗

PubMed2002

[Comparison of effect on S.mutans producing acid ability between organic weak acid and fluoride].

OBJECTIVE: To figure out the effects of organic weak acids, benzoate, citric acid and malic acid on the main cariogenic bacteria S.mutans Ingbritt. To evaluate the possibility of above weak acids as anti-caries reagents. METHODS: S.mutans Ingbritt was inoculated into tryptic soy broth containing different concentrations of fluoride, benzoate, citric acid and malic acid, grew in anaerobic conditions at 37 degrees centigrade for 48h. The final pH values of suspension were measured. RESULTS: Fluoride had best inhibitory effect on S.mutans Ingbritt in low concentrations, whereas other 3 weak acids, benzoate, citric acid and malic acid could inhibit S.mutans Ingbritt in a higher concentrations. The order of effectiveness was fluoride>malic acid>benzoate>citric acid. CONCLUSION: Fluoride has the best inhibitory effect on S.mutans producing acid ability. Though weak acids benzoate, malic acid and citric acid in high concentration had different inhibitory effects on S.mutans Ingbritt, however high concentration of organic acids can make enamel demineralization.

English Abstract↗