Biomedical subjects

Can Cai

Publications and source records attributed to Can Cai.

3 recordsLinked to original sources

PubMed2005

Trial-to-trial variability and its effect on time-varying dependency between two neurons.

The joint peristimulus time histogram (JPSTH) and cross-correlogram provide a visual representation of correlated activity for a pair of neurons, and the way this activity may increase or decrease over time. In a companion paper we showed how a Bootstrap evaluation of the peaks in the smoothed diagonals of the JPSTH may be used to establish the likely validity of apparent time-varying correlation. As noted in earlier studies by Brody and Ben-Shaul et al., trial-to-trial variation can confound correlation and synchrony effects. In this paper we elaborate on that observation, and present a method of estimating the time-dependent trial-to-trial variation in spike trains that may exceed the natural variation displayed by Poisson and non-Poisson point processes. The statistical problem is somewhat subtle because relatively few spikes per trial are available for estimating a firing-rate function that fluctuates over time. The method developed here decomposes the spike-train variability into a stimulus-related component and a trial-specific component, allowing many degrees of freedom to characterize the former while assuming a small number suffices to characterize the latter. The Bootstrap significance test of the companion paper is then modified to accommodate these general excitability effects. This methodology allows an investigator to assess whether excitability effects are constant or time-varying, and whether they are shared by two neurons. In data from two V1 neurons we find that highly statistically significant evidence of dependency disappears after adjustment for time-varying trial-to-trial variation.

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PubMed2005

Statistical assessment of time-varying dependency between two neurons.

The joint peristimulus time histogram (JPSTH) provides a visual representation of the dynamics of correlated activity for a pair of neurons. There are many ways to adjust the JPSTH for the time-varying firing-rate modulation of each neuron, and then to define a suitable measure of time-varying correlated activity. Our approach is to introduce a statistical model for the time-varying joint spiking activity so that the joint firing rate can be estimated more efficiently. We have applied an adaptive smoothing method, which has been shown to be effective in capturing sudden changes in firing rate, to the ratio of joint firing probability to the probability of firing predicted by independence. A bootstrap procedure, applicable to both Poisson and non-Poisson data, was used to define a statistical significance test of whether a large ratio could be attributable to chance alone. A numerical simulation showed that the bootstrap-based significance test has very nearly the correct rejection probability, and can have markedly better power to detect departures from independence than does an approach based on testing contiguous bins in the JPSTH. In a companion paper, we show how this formulation can accommodate latency and time-varying excitability effects, which can confound spike timing effects.

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PubMed2003

Statistical smoothing of neuronal data.

The purpose of smoothing (filtering) neuronal data is to improve the estimation of the instantaneous firing rate. In some applications, scientific interest centres on functions of the instantaneous firing rate, such as the time at which the maximal firing rate occurs or the rate of increase of firing rate over some experimentally relevant period. In others, the instantaneous firing rate is needed for probability-based calculations. In this paper we point to the very substantial gains in statistical efficiency from smoothing methods compared to using the peristimulus-time histogram (PSTH), and we also demonstrate a new method of adaptive smoothing known as Bayesian adaptive regression splines (DiMatteo 1, Genovese C R and Kass R E 2001 Biometrika 88 1055-71). We briefly review additional applications of smoothing with non-Poisson processes and in the joint PSTH for a pair of neurons.

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