Biomedical subjects

Carl Ganter

Publications and source records attributed to Carl Ganter.

5 recordsLinked to original sources

PubMed2007

MRI of the lung: value of different turbo spin-echo, single-shot turbo spin-echo, and 3D gradient-echo pulse sequences for the detection of pulmonary metastases.

PURPOSE: To compare the value of different MRI sequences of the lung for the detection of pulmonary metastases. MATERIALS AND METHODS: A total of 28 patients with 225 pulmonary metastases confirmed at multidetector-row computed tomography (MDCT) underwent MRI of the lung, including breathhold T2-weighted single-shot turbo spin-echo (half-Fourier single-shot turbo spin-echo [HASTE] and inversion recovery [IR]-HASTE) and conventional turbo spin-echo (TSE and short-tau inversion recovery [STIR]) sequences, a respiratory- and pulse-triggered black-blood STIR sequence (triggered STIR), and breathhold pre- and postcontrast volumetric interpolated 3D gradient-echo (VIBE) sequences. MR images were reviewed by three independent observers and results were correlated with MDCT, which served as standard of reference. Lesion-to-lung contrast-to-noise ratios (CNRs) and image artifacts were also assessed. RESULTS: CNRs were highest on TSE images (P < 0.001). Mean sensitivities for lesion detection with triggered STIR, TSE, and STIR were 72.0%, 69.0%, and 63.4%, respectively. With HASTE, IR-HASTE, and pre- and postcontrast VIBE, significantly lower sensitivities were obtained (P < 0.05), although artifacts due to physiological motion were less distinct with these sequences compared to TSE and STIR (P < 0.05). CONCLUSION: Conventional TSE sequences are more sensitive in depicting pulmonary metastases than single-shot TSE or 3D gradient-echo sequences. Respiratory and pulse triggering can improve lesion detection, but increases acquisition time substantially.

Adult↗

PubMed2006

Steady state of gradient echo sequences with radiofrequency phase cycling: analytical solution, contrast enhancement with partial spoiling.

Spoiled gradient echo sequences can only reach a homogeneous steady state if sufficiently strong crusher gradients are used in combination with RF phase cycling (RF spoiling). However, the signal depends quite sensitively on the chosen phase increment phi and-lacking analytical solutions-numerical simulations must be used to study the transient and steady-state magnetization. For the steady state an exact analytical solution is derived, which holds for arbitrary sequence and tissue parameters. Besides a considerably improved computation performance, the analytical approach enables a better understanding of the complicated dependence on phi. For short repetition times (TR) the regime of small phi turns out to be particularly interesting: It is shown that the typical phi(c), where RF spoiling starts to become effective, is essentially inversely proportional to T(2). This tissue dependence implies that contrasts can be considerably larger with partial spoiling (phi approximately phi(c)) than with conventional RF spoiling (phi >> phi(c)). As an example, the uptake of contrast agents in tissues is investigated. For typical parameters a considerably improved contrast enhancement can be obtained, both theoretically and experimentally.

Adult↗

PubMed2006

Static susceptibility effects in balanced SSFP sequences.

The steady state of balanced steady-state free precession (b-SSFP) sequences in presence of field inhomogeneities can be expressed in terms of a rapidly convergent series, which contains the characteristic function of the susceptibility related phase variations. As long as the intravoxel standard deviation sigma of the accumulated phase per repetition time (TR) is of order 1 (radians) or lower, the signal at TE=TR/2 behaves like a spin echo (SE), in accordance with recent observations. The signal decays quadratically around the maximum near TR/2 with a curvature, which solely depends on sigma and not on T'2. For larger sigma, a qualitative change toward a gradient echo (GRE) occurs and the signal shows characteristics of an usual FID. With increasing off-resonance the width of the SE regime decreases.

Algorithms↗

PubMed2006

Steady state of echo-shifted sequences with radiofrequency phase cycling.

Due to a delayed echo-formation, echo-shifted gradient echo sequences (ES-GRE) allow for an enhanced T(2)*-weighting at short repetition times. While they are in use with and without RF spoiling, analytical solutions are only known for the latter. The signal formation in the former could only be assessed in approximative form, so far. In this article an exact analytical solution is presented for TR-periodic ES-GRE sequences with RF phase cycling. Besides providing a better numerical performance, it should be useful for systematic sequence development. The relation to recent approximative solutions is discussed.

Algorithms↗

PubMed2004

Off-resonance effects in the transient response of SSFP sequences.

A previously developed eigenvector formalism is adapted to off-resonance in the transient response of quasiperiodic steady-state free precession (SSFP) sequences, including TrueFISP as a special case. The effective relaxation rates for essentially parallel and perpendicular deviations from the steady state are determined analytically in leading order perturbation theory. The latter are a known cause of oscillatory artifacts and therefore constitute the main target of a variety of preparation techniques. In addition, the former also play a dominating role in applications such as inversion recovery (IR) TrueFISP, which intentionally measure far away from the equilibrium. For both components, the approach toward equilibrium turns out to depend sensitively on field inhomogeneities, especially for smaller ratios of T2/T1. For the perpendicular deviations, the calculations show that--except very close to banding artifacts, where the steady-state signal is almost zero--field inhomogeneities additionally increase their effective relaxation rate almost as much as in the free induction decay (FID). The analytical results are tested against numerical simulation and MR measurements.

Adult↗