Biomedical subjects

Carlos Ferreira

Publications and source records attributed to Carlos Ferreira.

9 recordsLinked to original sources

PubMed2006

Joint transform correlator with spatial code division multiplexing.

A joint transform correlator may suffer from overlapping of the zero diffraction order of the output, which does not contain relevant information, and the correlation peaks that appear in the first diffraction orders if objects are not sufficiently separated. Such overlapping significantly reduces the signal-to-noise ratio of the identification process. We propose a novel approach based on code division multiplexing technique in which the contrast of the identification peaks is significantly enhanced. The approach does not include placing the two objects side by side but rather includes code multiplexing them. Moreover, the code division multiplexing technique allows the space-bandwidth product to be improved. Optical implementation results are given.

Journal Article↗

PubMed2006

Superresolved imaging of remote moving targets.

We present a superresolving approach that allows one to exceed the diffraction limit and recover highly resolved contours of moving targets from a sequence of low-resolution images. The presented approach is suitable for remote sensing applications. The resolution decoding algorithm that is used to recover the high-resolution features of the target can be run partially via optical means and that way can be used to reduce the required computational complexity.

Algorithms↗

PubMed2005

Spatial information transmission using orthogonal mutual coherence coding.

We use the coherence of a light beam to encode spatial information. We apply this principle to obtain spatial superresolution in a limited aperture system. The method is based on shaping the mutual intensity function of the illumination beam in a set of orthogonal distributions, each one carrying the information for a different frequency bandpass or spatial region of the input object. The coherence coding is analogous to time multiplexing but with multiplexing time slots that are given by the coherence time of the illumination beam. Most images are static during times much longer than this coherence time, and thus the increase of resolution in our system is obtained without any noticeable cost.

Journal Article↗

PubMed2005

Heritable factors shape natural human IgM reactivity to Ro60/SS-A and may predispose for SLE-associated IgG anti-Ro and anti-La autoantibody production.

Systemic lupus erythematosus (SLE) is characterized by various IgG autoreactivities, among which anti-Ro/SS-A is particularly pathology-associated and early detectable. SLE also shows significant familial aggregation, but genetic factors are not well understood and remain controversial for disease-associated IgG. Here we report that IgM anti-Ro showed a uniquely high degree of heritability in a study of SLE-affected families. Unlike IgM anti-La or anti-dsDNA, IgM anti-Ro was also significantly correlated to IgG anti-Ro among SLE patients, as well as to IgG anti-La and anti-dsDNA. We conclude that largely genetically determined, thus natural IgM anti-Ro-bearing precursor B-cells, may be an important factor for class switching and determinant spreading in early phases of SLE pathogenesis. Furthermore, we found unexpected sex differences in isotype/specificity correlations among SLE-unaffected relatives and control subjects, which could help understand the strong gender bias associated with SLE. We propose that the study of such correlation structures may reveal characteristic spreading pathways relevant for human SLE.

Adolescent↗

PubMed2004

Recognition of polychromatic three-dimensional objects.

We propose to use optical multichannel correlation in various chromatic systems to obtain a setup for recognition of polychromatic three-dimensional (3-D) objects based on Fourier-transform profilometry. Because red-green-blue color components are not able to split the luminance information of objects in a defined component, when the 3-D objects are brighter than the reference objects the correlation result gives false alarms. We demonstrate that it is possible to use different color spaces that can split luminance from chromatic information to yield adequate recognition of polychromatic 3-D objects. We show experimental results that prove the utility of the proposed method.

Journal Article↗

PubMed2004

Quantitative evaluation of a pulmonary contour segmentation algorithm in X-ray computed tomography images.

RATIONALE AND OBJECTIVES: Pulmonary contour extraction from thoracic x-ray computed tomography images is a mandatory preprocessing step in many automated or semiautomated analysis tasks. This study was conducted to quantitatively assess the performance of a method for pulmonary contour extraction and region identification. MATERIALS AND METHODS: The automatically extracted contours were statistically compared with manually drawn pulmonary contours detected by six radiologists on a set of 30 images. Exploratory data analysis, nonparametric statistical tests, and multivariate analysis were used, on the data obtained using several figures of merit, to perform a study of the interobserver variability among the six radiologists and the contour extraction method. The intraobserver variability of two human observers was also studied. RESULTS: In addition to a strong consistency among all of the quality indexes used, a wider interobserver variability was found among the radiologists than the variability of the contour extraction method when compared with each radiologist. The extraction method exhibits a similar behavior (as a pulmonary contour detector), to the six radiologists, for the used image set. CONCLUSION: As an overall result of the application of this evaluation methodology, the consistency and accuracy of the contour extraction method was confirmed to be adequate for most of the quantitative requirements of radiologists. This evaluation methodology could be applied to other scenarios.

Algorithms↗

PubMed2004

Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.

Several lines of evidence implicate the Cytotoxic T Lymphocyte Antigen 4 (CTLA4) gene in susceptibility to autoimmune disease. We have examined the association of systemic lupus erythematosus (SLE) with polymorhisms within the CTLA4 gene that were previously proposed to regulate CTLA-4 function: a single nucleotide polymorphism (SNP) in position +49 of exon 1 and a dinucleotide repeat in the 3' untranslated region (3'UTR). The 3'UTR repeat showed a significant association with SLE, with one allele conferring susceptibility and another conferring protection to the disease. The associated alleles do not support previous suggestions of an allele size-dependent effect of the 3' UTR polymorphism in autoimmunity development and instead suggest that it is in linkage disequilibrium with a true causative locus. No association of the exon 1 SNP with SLE was found in our population. Given the conflicting results obtained in different studies on the association of SLE with this polymorphism, we performed a meta-analysis including seven previously published studies and the present one. Significantly increased and decreased risks for SLE were found for carriers of the G allele and the A allele, respectively. The functional characterization of disease-associated CTLA4 gene variants is now required to elucidate their role in the pathogenesis of SLE and other autoimmune diseases.

Alleles↗

PubMed2002

Optical implementation of the weighted sliced orthogonal nonlinear generalized correlation for nonuniform illumination conditions.

Optical pattern recognition under variations of illumination is an important issue. The sliced orthogonal nonlinear generalized (SONG) correlation has been proposed as an optical pattern recognition tool to discriminate with high efficiency between objects. But, at the same time, the SONG correlation is very sensitive to gray-scale image variations. In a previous work, we expanded the definition ofthe SONG correlation to the Weighted SONG (WSONG) correlation to modify the discrimination capability in a controlled way. Here, we propose to use the WSONG when pattern recognition is obtained by means of optical correlation under nonuniform illumination. The calculation of the WSONG correlation requires the summation of many linear correlations between binary images. To implement it optically, we use a time sequential joint transform correlator.

Journal Article↗

PubMed2002

Recognition of unsegmented targets invariant under transformations of intensity.

Images taken in noncooperative environments do not always have targets under the same illumination conditions. There is a need for methods to detect targets independently of the illumination. We propose a technique that yields correlation peaks that are invariant under a linear intensity transformation of object intensity. The new locally adaptive contrast-invariant filter accomplishes this by combining three correlations in a nonlinear way. This method is not only intensity invariant but also has good discrimination and resistance to noise. We present simulation results for various intensity transformations with and without random and correlated noise. When the noise is high enough to threaten errors, the method trades off intensity invariance in order to achieve the optimum signal to noise ratio, and the peak to sidelobe ratio in the presence of clutter is always greater than one. In the presence of random disjoint noise, the signal to noise ratio is independent of the target contrast and of the level of the noise.

Journal Article↗