Biomedical subjects

Carmen Vulpoi

Publications and source records attributed to Carmen Vulpoi.

4 recordsLinked to original sources

PubMedDate not supplied

[Hyperprolactinemia and pregnancy].

Prolactin is a polipeptidic hormone secreted by the anterior pituitary gland, whose main role consists in the stimulation of lactation in the postpartum period. The increasing of prolactin secretion can be physiological (pregnancy and lactation) or pathological (hypothalamic and pituitary diseases, iatrogenic, etc.). The suppression of the hypothalamic-pituitary-gonadal axis and the resistivity of the ovary and gonadotropin action are induced in hyperprolactinemia, the amenorrhea and lack of ovulation being the result. Infertility associated with hyperprolactinemia is reversible with treatment, irrespectively to the type of treatment (radical or medical). Lowering of prolactin levels to normal or near normal is often necessary to permit ovulation. Dopamine-like drogs, as bromocriptine, appear to be safe for the developing fetus, at lest when the treatment is interrupted in the first trimester of pregnancy.

Bromocriptine↗

PubMedDate not supplied

[Determination of urinary iodine as a marker of iodine deficiency].

PURPOSE: Determination of ioduria in order to establish the actual degree of iodine deficiency in school-age children from 4 counties in Moldavia. MATERIALS AND METHODS: Urinary iodine was determined in 927 school-children aged 7-14 years from 4 counties: Suceava, Iaşi, Neamţ and Botoşani. The determination was made by cerium-arsenate method and by a semi-quantitative method. RESULTS: The median value of ioduria was 3 micrograms/dL in Suceava, 8.8 micrograms/dL in Iaşi, 7.1 micrograms/dL in Botoşani. In Roman-Neamţ 93.75% of all samples had a value of ioduria below 10 micrograms/dL. From this point of view, Suceava and Roman are with moderate iodine deficiency; Iaşi and Botoşani are with mild iodine deficiency. CONCLUSIONS: Despite the existence of a program of iodine prophylaxis, there are still many regions in Moldavia with iodine deficiency, so it is important to have more measures of sanitary education and prophylaxis in these regions.

Adolescent↗

PubMedDate not supplied

[Differentiated thyroid cancer--staging and prognostic systems].

Differentiated thyroid cancer (DTC), including papillary and follicular carcinoma with histological variants, has an excellent prognosis; nevertheless a subset of these tumours is clinically aggressive and, in some patients, fatal. Treatment of DTC remains controversial, regarding the extent of primary surgical resection, the need for lymph node dissection and the role of postoperative radioactive iodine ablation. In addition to the widely accepted TNM classification, recognition of significant risk factors and developing of staging systems, such as AMES, AGES, MACIS, MSKCC and NTCTCS, has helped to identify the patients with a potential aggressive course of the disease and high risk of recurrence. This has allowed the development of a rational and selective approach to therapy, thus, avoiding excessive treatment and subsequent morbidity without compromising the oncological outcome.

Carcinoma, Papillary↗

PubMedDate not supplied

[Differentiated thyroid cancer--peculiar morphological and clinical forms].

The most common clinical presentation of differentiated thyroid cancer (DTC), consisting of papillary and follicular adenocarcinoma (with their histological variants), is the solitary thyroid nodule. A review of the literature is performed in order to describe particular forms of DTC, in terms of incidence, diagnosis and treatment: occult carcinoma, carcinoma on aberrant thyroid tissue, "functional" thyroid carcinoma and familial non-medullary carcinoma. A particular interest is shown to the coexistence of malignancy with benign thyroid diseases, such as goiter, hyperthyroidism and Hashimoto's thyroiditis, as well as parathyroid adenoma. In conclusion, the authors emphasize that the association of carcinoma with benign thyroid conditions is not rare and it substantiate an aggressive approach in regard to diagnosis and treatment, increasing the indication for surgery and, moreover, for total thyroidectomy.

Adenocarcinoma, Follicular↗