[Adenoma of the cardia with atypical cells].
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Biomedical subjects
Publications and source records attributed to Carole Bonneau.
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We report two patients with keratoacanthoma, simple in one and multiple in the other, displaying typical histological features except for intravascular spread. Although this spread points to malignancy, it did not allow to rule out the diagnosis of keratoacanthoma. These aggressive histological features, as well as perineural invasion, are not linked to malignant clinical course, according to the literature. Intravascular spread suggests that keratoancanthoma could be considered as a peculiar form of well differentiated squamous cell carcinoma. Comparison between clinical and pathological observations should lead to more specific diagnosis.
II Gauge directional large core vacuum assisted biopsy has been used recently in the etiological diagnosis of microcalcifications. The objective of our work was to summarize the histological modifications resulting from vacuum biopsies observed on 31 surgical specimens issuing from a series of 109 biopsies performed over a 15-month period for malignant and borderline lesions. Histological modifications attributable to vacuum biopsies, scar tissue and displacements, were searched for in all cases. Scar tissue was seen as granulations, inflammation and hemorrhagic tissue associated or not with fat necrosis and/or foreign body giant-cell reaction. Displacements were seen as movements of injured tissue generally in the vicinity of scar tissue or vascular channels. Scar tissue was identified in all cases, presenting as star-shaped tissue measuring 12.8 mm on the average. Five displacements of either benign or malignant epithelia or of lymphovascular channels were observed (16% of the specimens). Scar tissue seen on surgical specimens indicates the location of the mammotome cut and confirms correctly directed surgery. It is particularly important to identify scar tissue because the lesions are nonpalpable and difficult to localize, or may have been totally removed at the initial biopsy. Displacements can be mistaken for infiltrating carcinoma or lymphatic invasion and must be carefully localized. They seem to be less frequent after vacuum biopsy.