Biomedical subjects

Carole Gengler

Publications and source records attributed to Carole Gengler.

6 recordsLinked to original sources

PubMed2005

Primary clear cell sarcoma of the ileum: an uncommon and misleading site.

A clear cell sarcoma, arising primarily in the ileum of a 35-year-old man, is reported. Histologically, the neoplasm infiltrated the full thickness of the intestinal wall. It consisted of strands and sheets of round to spindle-shaped cells with clear to eosinophilic cytoplasm, vesicular nuclei and prominent nucleoli. Vascular invasion was present at diagnosis. Tumour cells expressed S-100 protein, melan-A and tyrosinase. They were negative for HMB45, CD117, cytokeratins, epithelial membrane antigen, smooth muscle actin, desmin, CD31, CD34, chromogranin and synaptophysin. Reverse transcription-polymerase chain reaction analysis performed on paraffin-embedded tissue showed EWS-ATF1 fusion transcripts representative of the t(12;22) (q13;q12) clear cell sarcoma reciprocal translocation. The patient, who developed liver metastases 2 months after diagnosis, died of disease at 15 months. This case demonstrates that the gastrointestinal tract is a potential site for primary clear cell sarcoma of soft tissues, and, furthermore, that cytogenetics and/or molecular techniques play a central role in the diagnosis.

Adult↗

PubMed2005

[Thymic neuroendocrine tumors: report on 6 cases].

AIM: the aim of our study was to analyze a series of 6 thymic neuroendocrine tumors (TNET). METHODS: we report the clinical and pathological features of 6 TNET reclassified according to the last WHO classification (2004). RESULTS: there were 4 men and 2 women, (mean age of 61.3 years), presenting with local symptoms in 4 cases. The tumors were reclassified as 3 atypical carcinoids (AC), 2 small cell carcinomas (SCC) and 1 large cell neuroendocrine carcinoma (LCNEC). Cytokeratin, EMA and neuroendocrine markers were expressed in poorly-differentiated tumors. Two patients were lost of follow-up. Two patients with AC died of disease at 20 and 36 months. One patient with SCC died of disease at 2 years and the patient with the LCNEC died of disease in 3 months. CONCLUSION: TNET are poor prognosis tumors with a prognosis similar to thymic carcinomas. Adequate surgical resection is a strong prognosis factor.

Aged↗

PubMed2004

[Independent endometrial and ovarian carcinomas: two cases of synchronous and metachronous endometrioid carcinomas].

Simultaneous carcinomas involving both the ovary and the endometrium may cause diagnostic difficulties, particularly if the tumors have a similar histology. We report two cases of independent endometrioid carcinomas of the endometrium and the ovary. Tumor development was synchronous in one case and metachronous in the other. These cases illustrate the morphological criteria helpful in distinguishing independent primaries from metastatic carcinomas which have a different therapeutic implication. Endometrial tumors were intra-mucosal without myometrial or vascular invasion, or tubal involvement and were associated with atypical complex hyperplasia (case 2). The ovarian tumors were uninodular, unilateral, without hilar invasion and were associated with endometriosis (case 2). The prognosis of endometrioid type carcinomas is better than for other histological types of carcinoma. Both our patients are well and disease free at 27 and 24 months.

Carcinoma, Endometrioid↗

PubMed2003

[Placental site trophoblastic tumor of the uterus after in vitro fertilization. A case report with initial vaginal metastasis].

We report the first case of placental site trophoblastic tumor following in vitro fertilization. A 32-year-old woman presented with a vaginal polyp diagnosed 11 months after a successful fertilization, resulting in the delivery of a term male baby, but followed by persistent amenorrhea. The diagnosis of PSTT was done on examination of the vaginal polyp and the curettage specimen and was confirmed after hysterectomy. The patient was well 30 months later. The value of initial metastases limited to the pelvis and the role of in vitro fertilization in the pathogenesis of the tumor are discussed.

Adult↗

PubMed2003

[Inflammatory leiomyosarcoma: a case report].

We report an additional case of inflammatory leiomyosarcoma, arising in the shoulder of a 31-year-old male. The rare inflammatory variant of leiomyosarcoma tends to affect young adults. Histologically it is characterized by a prominent lymphohistiocytic infiltrate often masking fascicles of spindle cells, as well as the presence of clusters of xanthoma cells and psammoma bodies. Smooth muscle differentiation is supported by desmin and smooth muscle actin expression. The differential diagnosis includes so-called inflammatory 'malignant fibrous histiocytoma'and inflammatory myofibroblastic tumor. The outcome of this variant seems to be favorable.

Adult↗

PubMed2002

[Sarcomatoid carcinoma of small intestine: diagnostic problems raised by an unusual tumor].

Sarcomatoid carcinomas involving the intestinal tract are rare and usually associated with poor prognosis. We report a case of sarcomatoid carcinoma of the ileum, diagnosed in a 61-year-old man. The patient presented with acute intestinal occlusion. Surgical resection of the ileum was performed. At macroscopic examination, two large polypoid masses were found. Frozen section examination suggested the diagnosis of malignant stromal tumor. At histological examination, both tumors were formed by pleiomorphic, large spindle cells, presenting numerous mitoses and marked nuclear atypia. Immunohistochemical examination showed that tumor cells coexpressed vimentin and epithelial markers (cytokeratins, EMA). The final diagnosis was monomorphic sarcomatoid carcinoma. The patient deceased with metastatic disease after 3 months of follow-up. This report underlines the potential diagnostic problems raised by this unusual type of carcinoma and emphasizes the role of immunohistochemistry in assessing the correct diagnosis.

Carcinoma↗