Biomedical subjects

Carrie Gibbons

Publications and source records attributed to Carrie Gibbons.

4 recordsLinked to original sources

PubMed2006

Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.

Adrenomedullin (AM) is a 52-amino-acid multifunctional peptide that circulates in the plasma in the low picomolar range and can exert a multitude of biological effects through an autocrine/paracrine mode of action. The mechanism by which AM transduces its signal represents a novel and pharmacologically tractable paradigm in G protein-coupled receptor signaling. Since its discovery in 1993, the study of AM has emerged into a new field of research with nearly 1800 publications that rivals the renown of other common factors like angiopoetin (1015 publications) and ghrelin (1550 publications). Despite the tremendous strides made in recent years toward unveiling the biochemical and cellular functions of AM, we are still lagging in our understanding of the essential roles of AM in normal and disease physiology. As discussed in this current review, a concerted effort to combine information from clinical, genomic, biochemical, and genetic mouse model sources can provide a focused view to help define the physiological functions of AM. Specifically, we find that certain conditions, such as pregnancy, cardiovascular disease, and sepsis, are associated with robust and dynamic changes in the expression of AM and AM receptor proteins, which together represent an elegant mechanism for altering the physiological responsiveness or function of AM. Thus, the modulation of AM signaling may be further exploited for therapeutic strategies in the management and treatment of human disease.

Adrenomedullin↗

PubMedDate not supplied

A comparison of client and mental health worker assessment of needs and unmet needs.

This study was set up to examine agreement on needs identified by mental health clients and their primary mental health workers. Mental health workers assessed a convenience sample of clients who completed an interview about the services they receive. Data were collected from 78 client and staff dyads regarding 11 need domains. Mental health workers and clients did not agree on the number of needs (ICC = 0.42). Kappa coefficients indicated significant agreement between staff and clients for only 1 of the 11 need domains (vocational need kappa = 0.67; others ranged from 0 to 0.58). The data further revealed that mental health workers and clients disagreed about unmet needs (kappa ranged from -0.07 to 0.46). These findings show that clients and staff have divergent opinions regarding needs. Integrating clients' perspectives into treatment plans may help address this issue.

Adult↗

PubMedDate not supplied

Visual attention and older drivers: the contribution of inhibition of return to safe driving.

Increasing data suggest that visual attention may be impaired in some older drivers, and that such impairment may be related to poorer driving abilities and a higher crash risk. Because effective scanning of the environment is important for safe driving, the authors sought to examine the relationship between a reflexive visual attention mechanism and driving. To examine this issue the authors conducted a preliminary study using the inhibition of return (IOR) paradigm, which has been labeled as a fundamental search mechanism. Forty-one drivers aged 55 and over completed two on-road driving evaluations and IOR testing. After accounting for the contribution of age, IOR statistically predicted overall driving evaluation scores (p = .045), and the number of errors in scanning the environment (p = .031). To the authors' knowledge these findings represent the first documentation of a relationship between IOR and driving. The results are informative regarding the importance of reflexive visual attention mechanisms towards safe driving.

Aged↗

PubMedDate not supplied

Evaluation of a re-training program for older drivers.

BACKGROUND: Some older drivers may have a higher crash risk than others. Because many of these drivers have not received formal driving training, we evaluated the effectiveness of a re-training program for older drivers as it is currently being offered. Specifically, we examined if older drivers who received the training would have better scores on a driving evaluation than drivers who did not receive the training. METHODS: We used a randomized controlled trial. Participants first took part in on-road driving evaluations (possible scores ranged from 0 to 100), after which they were block randomized into training (treatment) or waiting (control) groups based on the driving evaluation results, age, and sex. Individuals in the treatment group attended driver re-training sessions, and were tested once more with the on-road test. Those in the control group completed their second driving evaluation and were then offered the re-training sessions. The second evaluations took place approximately two months after the first evaluations. RESULTS: Sixty-five participants completed two driving evaluations. Despite the overall improvement in driving scores (3.73, SD = 6.87, p = 0.001), we found no statistically significant difference between the control and treatment groups. The mean improvement for the control group was 3.46 (SD=6.72) compared to 4.02 (SD=7.11) for the treatment group (p = 0.747). Drivers' age was related to overall driving scores (r = -0.55, p = 0.001) but not changes between the first and second evaluations (r = 0.01, p = 0.955). INTERPRETATION: Although we have not demonstrated a statistically significant impact of the intervention, the overall increase suggests that an initial driving evaluation may underestimate the actual driving ability of many older drivers. Furthermore, although older drivers may have lower driving scores initially, they have the ability to improve on these scores. These findings should encourage us to explore diverse approaches to improve driving safety.

Accident Prevention↗