Biomedical subjects

Caterina Lombardo

Publications and source records attributed to Caterina Lombardo.

6 recordsLinked to original sources

PubMed2026

Long-term efficacy of cognitive behavioural therapy for insomnia (CBT-I) on depressive symptoms: A systematic review and meta-analysis of randomised controlled trials.

Depressive symptoms are common in individuals with persistent insomnia. Previous meta-analyses of randomised controlled trials (RCTs) showed that cognitive behavioural therapy for insomnia (CBT-I) can reduce depressive symptoms at post-treatment. However, the long-term maintenance of these improvements has never been systematically examined. To fill-in this gap, we conducted a systematic review and meta-analysis of the long-term (≥3 months) effects of CBT-I on depressive symptoms. The review was registered in PROSPERO (CRD420251146061). Only RCTs in adults with insomnia were considered. Pubmed, Scopus, Psycinfo, CINAHL, and Medline were searched up to 12 September 2025 with no predefined time constraints. From 5359 records initially retrieved, we included 53 articles reporting on 13,608 individuals. After outliers removal, random effects meta-analysis showed that CBT-I was superior to control conditions in reducing depressive symptoms at 3 [k = 29, d = -.35, [95% CI: -.49 to -.21], p < .001], 6 [k = 29, d = -.32, [95% CI: -.59 to -.05], p = .018], and 12 [k = 10, d = -.25, [95% CI: -.39 to -.12], p < .001] months follow-ups. Results demonstrate that the effects of CBT-I on depressive symptoms are sustained throughout the year following treatment, although effects may decline over time.

Humans↗

PubMed2006

Insomnia and its comorbidities in chronic kidney disease.

Sleep disorders are among the factors that can reduce the quality of life in patients with chronic kidney disease. Chronic kidney disease patients could benefit from an accurate evaluation and treatment of insomnia because this sleep disorder is associated with a high persistence-relapse rate, poor physical health, and mental disease (anxiety, depression) both in terms of comorbidity and antecedent. A multilayer evaluation of insomnia is possible because of valid and reliable instruments (both objective and subjective). Furthermore, a rational etiologic model of insomnia allows better understanding and treatment as a result of effective cognitive-behavioral techniques.

Chronic Disease↗

PubMed2005

Quality of sleep and P300 amplitude in primary insomnia: a preliminary study.

STUDY OBJECTIVE: The aim of this study is to evaluate whether the cortical arousal level in subjects with primary insomnia varies according to their quality of nighttime sleep. DESIGN: The P300 ERP was recorded each day, before and after sleep actigraphically monitored for 1 week. For each participant, the nights of worst- and best-quality sleep were identified. PARTICIPANTS: Seven subjects with primary insomnia and 7 control subjects. MEASUREMENTS AND RESULTS: The P300 amplitudes were compared by considering group (insomnia vs control), night (worst vs best), and moment of recording (before vs after sleep) as factors. The subjects with insomnia showed higher P300 amplitudes, as compared with amplitudes of control subjects, only for the worst night of sleep. CONCLUSIONS: Results indicate a relationship between variations in sleep quality and cortical arousal level in subjects with primary insomnia.

Adult↗

PubMed2003

Peripheral temperature changes during rest and gender differences in thermal biofeedback.

Thermal biofeedback (BFB) training is used extensively in clinical psychophysiology. However, there are large individual differences in the ability to control peripheral skin temperature and the magnitude of changes obtained varies considerably across studies. The aims of this study were: (1) to investigate the relationship between spontaneous peripheral temperature changes and changes voluntarily produced through a six-session thermal BFB training and (2) to investigate whether gender or other subjects' variables (trait anxiety, locus of control (LC) and field dependence) were related to learning of voluntary control of peripheral skin temperature. Results demonstrated that during the rest period preceding the feedback trials, there were consistent systematic temperature increases in which changes were bigger than those recorded in the BFB increase trials; among the subjects' variables considered, the only one that correlated significantly with learning ability was gender: Females showed greater control than males. Implications for clinical practice are discussed.

Adult↗

PubMed2003

P300 amplitude in subjects with primary insomnia is modulated by their sleep quality.

OBJECTIVE: The hyperarousal hypothesis is evaluated while controlling the influence of the quality of sleep in the night preceding the evaluation. METHOD: Eleven primary insomniacs and 11 healthy age matched controls participated to the study. Participants filled in 2 weeks of sleep logs and self-monitored their subjective tension the evening before and the morning after each night. Afterwards, subjects were called in to the Lab for a recording session of the P300 ERP (oddball paradigm) once after a night of bad sleep quality (N-) and once after a night of good sleep quality (N+). RESULTS: The main result of the present study indicated that the P300 amplitude at Fz in insomniacs resulted higher following a N- and lower following a N+ with respect to controls. CONCLUSIONS: This result suggests that cortical hyperarousal in primary insomniacs is not a stable individual characteristic, but is associated with the poor quality of their nocturnal sleep.

Adolescent↗

PubMed2002

Are polysomnographic measures of sleep correlated to alexithymia? A study on laboratory-adapted sleepers.

OBJECTIVE: Since recent findings have pointed to a correlation between alexithymia and measures of poor sleep quality during the first night of adaptation to a sleep laboratory, the aim of the current study was to assess the same relation in healthy laboratory-adapted sleepers. As a further measure of rapid eye movement (REM) sleep characteristics, REM density was also measured. METHODS: Twenty-seven male subjects, without sleep or psychiatric disorders, filled out the 20-item Toronto Alexithymia Scale (TAS-20) and slept for two consecutive undisturbed nights. Polysomnography and REM density were measured in the postadaptation night. RESULTS: Alexithymia scores did not correlate significantly with any polysomnographic variable or with REM density. Only the Externally Oriented Thinking (EOT) subscale showed a negative association with REM latency. Multiple regression on selected sleep measures as predictors confirmed these results. CONCLUSION: Results do not extend to normal sleep the association previously found between alexithymia and a poor quality of sleep during the adaptation night in the sleep laboratory. The only polysomnographic measure showing an association, albeit little, with one facet of alexithymia was REM latency.

Adult↗