Biomedical subjects

Catherine Thomas-Antérion

Publications and source records attributed to Catherine Thomas-Antérion.

5 recordsLinked to original sources

PubMed2006

Phenotype associated with APP duplication in five families.

Different duplications of the APP locus have been identified in five families with autosomal dominant early onset Alzheimer's disease (ADEOAD) and Abeta-related cerebral amyloid angiopathy (CAA). This study describes the phenotype of this new entity. Clinical, neuropsychological, imagery and neuropathological data were reviewed. The phenotype was not dependent on the size of the duplication and there was no clinical feature of Down's syndrome. Dementia was observed in all cases; intracerebral haemorrhage (ICH) was reported in 6 (26%) and seizures occurred in 12 (57%) of 21 patients. Age of onset of dementia ranged from 42 to 59 years, ICH from 53 to 64 years and age at death from 46 to 75 years. The neuropathological findings in five cases demonstrated Alzheimer's disease and severe CAA lesions that were reminiscent from those reported in brains of Down's syndrome patients. A striking feature consisted in intraneuronal Abetax-40 accumulation located in the granular cell layer of the dentate gyrus and in the pyramidal cell layer of the Ammon's horn.

Adult↗

PubMed2006

[Idiopathic normal pressure hydrocephalus].

In normal pressure hydrocephalus (NPH), the physiological alterations related to the ventricular dilatation that lead to the Hakim and Adams clinical syndrome (gait apraxia, incontinence and dementia) remain unclear. The correlation between the clinical syndrome and global or regional cerebral blood flow (CBF) is not established. The question whether the CBF reduction is the cause or the consequence of the neural dysfunction remains unsolved. Dementia of NPH may be a combination of fixed and potentially treatable pathologies. Expectations for improvement in the dementia of NPH must be tempered by the knowledge that they may be fixed tissue damage prior treatment. The overall poor clinical outcome after shunting with regard to dementia, when contrasted with responses in gait and continence, suggests differences in aetiology or reversibility of the pathology underlying these symptoms. It is not easy to choose elderly patients (perhaps patient with more impaired psychometric performances) that might respond to a shunt.

Aged↗

PubMed2006

[Short public events memory evaluation: the EVE-10 battery contribution].

Remote memory includes autobiographical memory and memory for public events and famous people. Amnesia for public events can be associated or not with deficits in autobiographical memory, and anterograde amnesia. It could extend on various periods of time and involve all or only parts of remote memory. We present a short version (EVE-10) of a previous 30-item scale (EVE-30), assessing memory for public events. Ten events which occurred from 1950 to 2001, were assessed by free recall, recognition, questions on details and research for flashbulb memories. The scale was administrated to 108 subjects aged from 20 to 79 years. Higher scores were observed in older subjects, men, and people with higher education. Flash bulb memories were found in 51,8% of subjects for the death of Lady Di and in 98,1% for the terrorist attack against the Twin Towers.

Adult↗

PubMed2006

[Role of personality, familial environment, and severity of the disease on the behavioral and psychological symptoms of dementia].

The phenomenology of Behavioral and Psychological Symptoms of Dementia (BPSD) occurring in the Alzheimer's disease and related syndromes remains not well known. The goal of this study was to assess the role of disorders of personality, psychiatric disorders and home environment in the occurence of the BPSD; 99 inpatients from a short-term Alzheimer unit were included in the study. BPSD were assessed by the NeuroPsychiatric Inventory, the severity of dementia by the MMSE. Previous somatic, psychiatric and personality disorders were evaluated by a semi-structured interview of the family, and classified according to the A, B and C groups from the DSM-IV. Eighty eight percent of the patients presented at least one BPSD. The patients whose the main caregiver was a spouse appeared to be more aggressive. Sixty seven per cent of the patients presented with former disorders of personality; they were more delirious, more anxious, more irritable and suffered more disorders of appetite. Each type of personality disorder modified the phenomenology of the BPSD. The severity of dementia does not seem sufficient to explain the occurrence of BPSD. Other factors seem to play a dominating part such as the previous disorders of personality and psychiatric antecedents. However, the exact links between disorders of personality, psychiatric antecedents and BPSD remain difficult to specify.

Dementia↗

PubMed2002

Evidence for a selective deficit in automatic activation of positive information in patients with Alzheimer's disease in an affective priming paradigm.

Using an affective priming paradigm, we studied the automatic and unconscious activation of emotional information in long-term memory. Participants had to judge target words preceded by various primes as positive or negative. The primes were masked and the SOA between the onset of primes and the onset of targets was 50 ms. Our results showed that in patients with dementia of the Alzheimer type (DAT), the negativity bias was preserved and the emotional priming effect was perturbed with positive targets. In control participants, this priming effect was restricted to negative targets. These findings are discussed in terms of preserved automatic activation of emotional information in Alzheimer's disease (AD) and in terms of an early deficit of the left hemisphere in AD making positive information more vulnerable to disease.

Aged↗