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Cebrail Kisa

Publications and source records attributed to Cebrail Kisa.

6 recordsLinked to original sources
PubMed2006

Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women.

Neuroplastic processes are thought to be involved in the pathophysiology of many psychiatric disorders, including major depression. It has been hypothesized that the brain-derived neurotrophic factor (BNDF), a key factor in neuroplasticity, is associated with depressive disorders. Our study evaluated the pre- and post-treatment levels of BDNF in a group of depressed patients and compared them with healthy controls. In order to exclude the effects of gender on neuroplasticity, our study group was restricted to women exclusively and consisted of 20 depressive patients and 20 healthy controls, with similar age and educational level distribution. Blood samples were collected before the treatment and on the sixth week of the treatment with 10 mg S-citalopram. The pre-treatment BDNF levels of the depressed patients were found to be lower than those of the healthy subjects. During the sixth week, the BDNF levels of depressive patients were significantly higher than the pre-treatment levels but similar to those of control subjects. These findings suggest that BDNF level may be an important factor in the etiopathogenesis of depression and may have a role in the action mechanism of antidepressant drugs.

Adolescent↗
PubMed2005

IL-6 levels decrease with SSRI treatment in patients with major depression.

OBJECTIVE: Some evidence indicates that an immune response with an increased production of proinflammatory cytokines often accompanies major depression. The objective of this study was to examine the serum levels of IL-6 in patients with major depression and the changes occurring in IL-6 levels during treatment with selective serotonin reuptake inhibitors (SSRI). METHOD: Twenty-three patients with a DSM-IV diagnosis of major depressive disorder and 23 healthy matched controls were included in the study. The severity of depression was measured with the Hamilton rating scale for depression. Blood samples for IL-6 levels were obtained at baseline and at week 6 of treatment and IL-6 concentrations were evaluated using a solid phase sandwich enzyme immunoassay. All patients were treated with an SSRI. RESULTS: The IL-6 levels showed no statistically significant difference between the patients and the controls at baseline. However, IL-6 levels after treatment with SSRIs were significantly lower compared with the baseline IL-6 levels of both the patients and the controls. CONCLUSION: The results of this study suggest that proinflammatory cytokines show some changes during the course of treatment of major depression. These findings might also be considered as supporting the hypothesis of a modulatory role of antidepressants on the immune system.

Adult↗
PubMed2005

Prolonged electroconvulsive therapy seizure in a patient taking ciprofloxacin.

Electroconvulsive therapy (ECT) can be used for the treatment of mental disorders, either alone or along with psychotropic agents and/or drugs for other medical conditions. We present in this case report a patient with postpartum depression on ciprofloxacin therapy for a urinary tract infection. The seizure in the first ECT treatment lasted for 30 seconds. While under the care of ECT, the patient was diagnosed as having a urinary tract infection; therefore, ciprofloxacin therapy of 1000 mg/day was initiated. Her second ECT seizure, which was on the third day of ciprofloxacin therapy, was terminated with 3 mg of intravenous midazolam at the 150th second. The ciprofloxacin therapy was discontinued. The patient had not previous history of epilepsy, and the investigation results for the extended seizure were found to be normal. The ECT therapy was restarted 3 days later, and total of 8 treatments were completed, lasting 35-70 seconds. Because the first ECT lasted for 30 seconds and subsequent therapy, which was reinitiated 3 days after the discontinuation of ciprofloxacin, lasted no longer than 70 seconds, the extended seizure in this patient is thought to be related to ciprofloxacin.

Adult↗
PubMed2005

[Impulsivity and mental disorders].

OBJECTIVE: Although there are several studies revealing the role of impulsivity in mental disorders, debates in the literature about how to define and determine impulsivity continue. Being a measurable feature of behaviour, impulsivity is defined as the failure to resist a drive or stimulus or as a personality dimension as the inability to resist the desire to harm one's self or others. Besides this negative definition, however, impulsivity is also defined as independent dysfunctional and functional concepts having both positive and negative consequences. It can be a psychopathological structural part of many mental disorders, but it can be a characteristic of normal behaviour as well. Although not defined in detail in DSM-IV, it is mentioned as a diagnostic criterion in several mental disorders like impulse control disorders (pathological gambling, intermittent explosive disorder, pyromania, kleptomania and trichotillomania), impulsive aggressive disorders of personality (borderline, antisocial, histrionic and narcissistic), manic episodes of bipolar disorder, attention deficit hyperactivity disorder (ADHD), neurological disorders with behavioural disinhibition and substance abuse. Studies have revealed impulsivity to be more common in subjects with conduct disorders, attention deficit hyperactivity disorder, disorders of personality, substance and alcohol abuse, psychotic disorders, bipolar disorders, eating disorders and dementia compared to healthy subjects in control groups. The aim of the present paper is to define impulsivity as a concept and symptom, to discuss its relation to mental disorders, to show the biological basis of this relationship and to review the literature relating to this issue.

Female↗
PubMed2004

[Mental disorders in the parents of bipolar patients].

OBJECTIVE: It is well known that bipolar disorder has familial transmission. Studies indicate that first-degree relatives of bipolar patients also have higher incidences of other mental disorders than the general population. The aim of this study is to determine the prevalence of mental disorders in the parents of bipolar patients. METHOD: Parents of 35 probands who were treated for their bipolar disorders and 35 age and gender matched healthy subjects' parents were assessed by means of the Structured Clinical Interview for DSM IV (SCID-I), and a questionnaire for the parents. RESULTS: Past and current mental disorders were present in 27.1% of the parents of bipolar patients but in 14.2% of the parents of normal controls; the difference between the groups is statistically significant. The most prevalent mental disorder in both groups is major depressive disorder. The parents of bipolar patients were more likely to have a family history of mental disorder (44.2%) than the control group (12.8%). Parents who had a current or past mental disorder were more likely to have a family history of mental disease. Offspring of in-bred families had more bipolar siblings. Bipolar children of parents who had a family history of mental disorder tended to have an earlier age of onset. CONCLUSION: The findings of this study indicate that there is an increased prevalence of bipolar disorders and other mental disorders in the parents of bipolar patients when compared to the parents of healthy controls.

Adult↗