Biomedical subjects

Cees van Leeuwen

Publications and source records attributed to Cees van Leeuwen.

17 recordsLinked to original sources

PubMed2006

Transient synchrony of distant brain areas and perceptual switching in ambiguous figures.

We studied the relationship between perceptual switching in the Necker cube and long-distance transient phase synchronization in EEG. Transient periods of response related synchrony between parietal and frontal areas were observed. They start 800-600, ms prior to the switch response and occur in pairs. Four types of pairs could be distinguished, two of which are accompanied by transient alpha band activity in the occipital area. The results indicate that perceptual switching processes involve parietal and frontal areas; these are the ones that are normally associated with various cognitive processes. Sensory information in the visual areas is involved in some, but not in all, of switching processes. The intrinsic variability, as well as the participating areas, points to the role of strategic cognitive processes in perceptual switching.

Adult↗

PubMed2006

The "mosaic stage" in amodal completion as characterized by magnetoencephalography responses.

We investigated the process of amodal completion in a same-different experiment in which test pairs were preceded by sequences of two figures. The first of these could be congruent to a global or local completion of an occluded part in the second figure, or a mosaic interpretation of it. We recorded and analyzed the magnetoencephalogram for the second figures. Compared to control conditions, in which unrelated primes were shown, occlusion and mosaic primes reduced the peak latency and amplitude of neural activity evoked by the occlusion patterns. Compared to occlusion primes, mosaic ones reduced the latency but increased the amplitude of evoked neural activity. Processes relating to a mosaic interpretation of the occlusion pattern, therefore, can dominate in an early stage of visual processing. The results did not provide evidence for the presence of a functional "mosaic stage" in completion per se, but characterize the mosaic interpretation as a qualitatively special one that can rapidly emerge in visual processing when context favors it.

Adult↗

PubMed2006

Asymmetric priming effects in visual processing of occlusion patterns.

In three experiments, we examined the effect of temporal context in amodal completion of partly occluded nontarget figures. In a primed same-different task, test pairs were preceded by a sequence of two primes, one of which was a single, the other a composite figure. Single figures reappeared in the composite ones, which also contained a square that could be viewed, alternatively, as an occluder or as yielding a mosaic fit to the other shape. To measure context influences between single and composite figures, both of which were nontargets, we studied their combined effect as primes on the test pairs of the same-different task, expecting that congruency between both primes should lead to a superadditive priming effect on the task. We found that single figures presented first provided facilitatory context for local and global occlusion as well as for mosaic interpretations of subsequently presented composite figures. These effects occurred only when the composite figure was presented briefly (50 msec). No superadditive facilitation occurred when composite figures were presented first and single figures followed them. The restriction of the effect to short presentations and its temporal asymmetry were taken as evidence that prior context biases possible occlusion interpretations during the process of completion, rather than afterward.

Adult↗

PubMed2005

Individual differences in perceptual switching rates; the role of occipital alpha and frontal theta band activity.

Prolonged presentation of visually ambiguous figures leads to perceptual switching. Individual switching rates show great variability. The present study compares individuals with high versus low switching rates by investigating human scalp electroencephalogram and blink rates. Eight subjects viewed the Necker cube continuously and responded to perceptual switching by pressing a button. Frequent switchers showed characteristic occipital alpha and frontal theta band activity prior to a switch, whereas infrequent switchers did not. The alpha activity was specific to switching, the theta activity was generic to perceptual processing conditions. A negative correlation was observed between perceptual switching and blink rates. These results suggest that the ability to concentrate attentional effort on the task is responsible for the differences in perceptual switching rates.

Adult↗

PubMed2005

Collinearity, curvature interpolation, and the power of perceptual integration.

In three experiments, participants determined the orientation of a global triangle formed by three Gabor patches of a target spatial frequency in a field of distracters. The orientation of the target patches and their proximity were varied between conditions. When all the target patches had the same orientation this facilitated the response compared to random orientations. This effect occurred only when the patches were in close proximity. When the orientations of the target patches were different but aligned to the global triangle, facilitation occurred regardless of proximity. These contrasting types of facilitation were attributed to different early perceptual integration mechanisms that enable the perception of holistic structure.

Adolescent↗

PubMed2005

Goodness takes effort: perceptual organization in dual-task settings.

We adopted the Psychological Refractoriness Paradigm to study whether perceptual Goodness affects the load of central processing resources. In three dual-task experiments, 2-Alternative Forced Choice auditory classification was followed by a same-different task in which Garner's classical five-dot patterns were presented. Goodness of these patterns and stimulus-onset asynchrony (SOA) between the first and second task were varied between trials. These factors had additive effects on response latencies and accuracy, indicating that pattern Goodness determines central processing load in performing the same-different task. In a fourth experiment, same-different judgment with Garner patterns was the single task. SOA between the first and second pattern was varied. Over-additive effects of Goodness with decreasing SOA were obtained, indicating sharing of central resources between consolidation of the first Garner pattern and performing the same-different task. Whereas, the resources needed for the latter, again, depend on Goodness, those needed for consolidation are independent of it.

Adult↗

PubMed2005

Evoked phase synchronization between adjacent high-density electrodes in human scalp EEG: duration and time course related to behavior.

OBJECTIVE: Data from a previous event-related potential (ERP) study in visual-perceptual grouping [Nikolaev AR, van Leeuwen C. Flexibility in spatial and non-spatial feature grouping: an event-related potentials study. Brain Res Cogn Brain Res 2004;22:13-25] were re-analyzed to identify event-related dynamics of phase-synchronization. METHODS: In 20 Hz activity, uniform spreading of phase synchronization in closely spaced (approximately 2 cm) scalp electrodes appears and disappears spontaneously. The lengths of synchronized activity intervals and how they vary as a function of stimulus presentation were compared between task and control conditions. RESULTS: Synchronization reached a maximum in the task condition about 180 ms post-stimulus onset, coinciding with the peak N180 ERP marking the deployment of task-specific attention. Synchronized intervals were longer in the task than in the control condition. Long (above 80 ms) intervals occurred at a stable rate before and just after stimulus onset, but steeply decreased 200-400 ms afterwards. CONCLUSIONS: Perceptual tasks lead to longer synchronized intervals in early visual areas. Attention deployment resets the ongoing synchronization. Event-related activity, besides low-frequency ERP, consists of high-frequency short and long synchronized intervals corresponding to evoked bursts and ongoing oscillations, respectively. SIGNIFICANCE: High-density scalp recorded EEG revealed synchronization dynamics in a local, early visual area of cortex that can be interpreted as modulation of spontaneous ongoing task-related processes by attention.

Adult↗

PubMed2005

Task-invariant aspects of goodness in perceptual representation.

In two experiments, pairs of Garner's classical 5-dot patterns were presented with an interstimulus interval of 500 ms in a same-different task in which a physical sameness criterion was used: Rotated or reflected versions of the same pattern were rated as different. Patterns varied in "goodness" according to Garner's equivalence set size measure. Both first and second pattern goodness affected reaction time and accuracy. This result and fits of models to reaction time data indicate that equivalence set representations are used in the task, as in a related categorical matching task in previous studies. Two effects were observed that contrast with the categorical matching task: One is a conflict between the need to respond different to patterns that are categorically equivalent under the equivalence set representation; the other is that extra time is needed for rechecking of the representation if pattern structures are hard to distinguish. In combination with previous studies, the present results show that even though the processes differ, the same representational mechanism is used across tasks.

Adult↗

PubMed2005

Phase synchronization analysis of EEG during attentional blink.

The attentional blink (AB) phenomenon occurs when perceivers must report two targets embedded in a sequence of distracters; if the first target precedes the second by 200-600 msec, the second one is often missed. We investigated AB by measuring dynamic cross-lag phase synchronization for 565 electrode pairs in 40-Hz-range EEG. Phase synchrony, on average, was higher in experimental conditions, where two targets are reported, than in control conditions, where only the second target is reported. The effect occurred in electrode pairs covering the whole head. Timing of the synchrony was crucial: Brief episodes of enhanced synchrony occurred 100-500 msec before expected target onset in AB conditions where the second target was correctly reported. These results show that intrinsic brain dynamics produce anticipatory synchronization in transient assemblies of cortical areas. Enhanced levels of anticipatory synchronization occur in response to the demands of the task in conditions where the system's limited capacity is under strain.

Adolescent↗

PubMed2004

Spatial and temporal structure of phase synchronization of spontaneous alpha EEG activity.

Spatiotemporal characteristics of spontaneous alpha EEG activity patterns are analyzed in terms of large-scale phase synchronization. During periods with strong phase synchronization over the entire scalp, phase patterns take either of two forms; one is a gradual phase shift between frontal and occipital regions and the other is a stepwise pattern with a sudden phase shift in the central region. The former is regarded as a traveling wave of electrocortical activity, of which the direction of propagation is predominantly from anterior to posterior in three out of four subjects, and opposite in the remaining one. The other activity pattern observed may correspond to a standing wave composed of two traveling waves propagating in opposite directions. The duration distributions of these patterns have similar forms within a subject, which suggests that they share the same mechanism for their generation.

Adolescent↗

PubMed2004

Flexibility in spatial and non-spatial feature grouping: an event-related potentials study.

Early perceptual grouping was studied using 256-channels event-related potentials in a choice response task. The task involved the detection of a triangle configuration of Gabor patches among patches of different spatial frequencies. The influence of two task-irrelevant factors was compared. One was the spatial proximity relation between the target patches and the other their relative orientation, a non-spatial relationship. Non-spatial effects were predominant in early peaks N64 and P100 in the occipital areas, and were reduced in size for later peaks. Spatial effects started from N180 in the occipital areas and continued in P250 and P430 in the central areas, increasing in size with time. These findings constitute a case of reversal of the usual order of spatial and non-spatial feature processing, illustrating that the flexibility in the early visual system may be greater than previously assumed.

Adult↗

PubMed2004

Amodal completion as reflected by gaze durations.

In two experiments amodal completion of partly occluded shapes was investigated by recording eye movements in a directed visual-search task. Participants searched arrays of shapes in a prescribed order for target figures that could partly be occluded. Longer gaze durations were found on occlusion patterns than on truncated control patterns for targets but not for non-targets. This effect of occlusion was restricted to a subset of the stimuli. A second experiment was carried out to establish whether this restriction resulted from structural properties of the stimuli or their familiarity. Occlusion patterns in this experiment were ambiguous with respect to structure, allowing both local and global completions. One of the completions was always less familiar than the other. The results showed longer gazes only for the less familiar completions, irrespective of whether they were local or global.

Adult↗

PubMed2004

Negative and positive congruence effects in letters and shapes.

In six experiments in which a binary classification task was used, letter and nonletter (geometrical shapes, pseudoletters, or rotated letters) targets were presented either in isolation or surrounded by a geometrical shape. The surrounding shape could be congruent or incongruent with the target. When the classification required a distinction between letters and nonletters, either explicitly (Experiments 1-3) or implicitly (Experiment 4), a negative congruence effect was obtained for letters, contrasting with a regular, positive congruence effect for nonletters. When no distinction was to be made, letters and nonletters invariably showed a positive congruence effect (Experiments 5 and 6). In particular, between Experiments 1-4 and Experiments 5 and 6, the occurrence of negative or positive congruence effects for the same stimuli depended on the task. Feature interaction, target selection, and response competition explanations were tested against a feature integration approach. The results are explained in terms of different feature integration strategies for letters and nonletters.

Adult↗

PubMed2003

Scale-invariant fluctuations of the dynamical synchronization in human brain electrical activity.

The dynamical properties of large-scale, long-term phase synchronization behavior in the alpha range of electroencephalographic signals were investigated. We observed dynamical phase synchronization and presented evidence of an underlying spatiotemporal ordering. Fluctuations in the duration of episodes of intermittent synchrony are scale-invariant. Moreover, the exponent used to describe this behavior is stable across different normal subjects. The results provide a new feature of self-organization in human brain activity and constitute a quantitative basis for modeling its dynamics.

Adolescent↗

PubMed2003

Dynamic synchronization and chaos in an associative neural network with multiple active memories.

Associative memory dynamics in neural networks are generally based on attractors. Retrieval based on fixed-point attractors works if only one memory pattern is retrieved at the time, but cannot enable the simultaneous retrieval of more than one pattern. Stable phase-locking of periodic oscillations or limit cycle attractors leads to incorrect feature bindings if the simultaneously retrieved patterns share some of their features. We investigate retrieval dynamics of multiple active patterns in a network of chaotic model neurons. Several memory patterns are kept simultaneously active and separated from each other by a dynamic itinerant synchronization between neurons. Neurons representing shared features alternate their synchronization between patterns, thus multiplexing their binding relationships. Our model includes a mechanism for self-organized readout or decoding of memory pattern coherence in terms of short-term potentiation and short-term depression of synaptic weights.

Animals↗

PubMed2003

Perceptual switching, eye movements, and the bus paradox.

According to a widely cited finding by Ellis and Stark (1978 Perception 7 575-581), the duration of eye fixations is longer at the instant of perceptual reversal of an ambiguous figure than before or after the reversal. However, long fixations are more likely to include samples of an independent random event than are short fixations. This sampling bias would produce the pattern of results also when no correlation exists between fixation duration and perceptual reversals. When an appropriate correction is applied to the measurement of fixation durations, the effect disappears. In fact, there are fewer actual button-presses during the long intervals than would be expected by chance. Moving-window analyses performed on eye-fixation data reveal that no unique eye event is associated with switching behaviour. However, several indicators, such as blink frequency, saccade frequency, and the direction of the saccade, are each differentially sensitive to perceptual and response-related aspects of the switching process. The time course of these indicators depicts switching behaviour as a process of cascaded stages.

Adult↗

PubMed2003

Parameter estimation of sigmoid superpositions: dynamical system approach.

Superposition of sigmoid function over a finite time interval is shown to be equivalent to the linear combination of the solutions of a linearly parameterized system of logistic differential equations. Due to the linearity with respect to the parameters of the system, it is possible to design an effective procedure for parameter adjustment. Stability properties of this procedure are analyzed.

Computer Simulation↗