Biomedical subjects

Cezary Chojnacki

Publications and source records attributed to Cezary Chojnacki.

4 recordsLinked to original sources

PubMed2006

[Nocturnal secretion of melatonin in subjects with asymptomatic and symptomatic Helicobacter pylori infection].

UNLABELLED: Melatonin is synthesized not only in the pineal gland, but also in gastrointestinal tract by enterochromaffin cells (EC) and it has a gastroprotective properties. Helicobacter pylori infection causes functional and organic changes of gastric mucosa, particularly in endocrine cells (D, G, ECL, EC). AIM: The aim of own studies was to evaluate nocturnal secretion of Melatonin in subjects with asymptomatic and symptomatic (dyspepsia, duodenal ulcer disease) H. pylori infection (Hp). MATERIAL AND METHODS: 116 subjects, aged 19-61 years were included in this study. Four groups were distinguished: group I (n=30) healthy subjects, Hp (-), group II (n=26)--subjects with asymptomatic infection Hp, group III (n=32) patients with ulcer-like dyspepsia, Hp (+), and group IV (n=28) patients with duodenal ulcer Hp(+). H. pylori infection was diagnosed by using urea breath test (UBT-(13)C) and rapid urease test. The concentration of melatonin in serum was measured with ELISA method, before and after eradication of H. pylori. Blood samples were taken for examination at 10:00 p.m., 2:00 a.m. and 6:00 a.m. RESULTS: The average melatonin concentration at night hours was found in group I--34.74 +/- 4.77 pg/ml, in group II--48.29 +/- 12.22 pg/ml (p < O.005), in group III--41.56 +/- 12.31 pg/ml (p > 0.05) and in group IV--26.16 +/- 6.89 pg/ml p < 0.01). Such statistical differences were not observed in all group after eradication H. pylori. CONCLUSIONS: (1) Nocturnal secretion of melatonin in subjects with asymptomatic infection of H. pylori is higher than in patients with ulcer-like dyspepsia and with duodenal ulcer disease. (2) Lower nocturnal secretion of melatonin probably may play role in pathogenesis of upper digestive tract diseases.

Adult↗

PubMed2004

[Inflammatory bowel diseases--imaging diagnostics].

The basic diagnostic procedure in ulcerative colitis is an endoscopy of gastrointestinal tract. It allows the macroscopic evaluation as well as the specimen taking for histological assessment what is the basis for ultimate diagnosis. In case of Crohn's disease the radiological diagnostics is of equal importance as endoscope evaluation. The imaging of inflammatory changes in Crohn's disease still poses some difficulties, especially, that located in the small intestine. Lately, the range of accessible examinations has been wider. We have in disposal the ultrasonography, the computed tomography, the magnetic resonance imaging and the capsular endoscopy. All of them are of great use in the diagnosis of Crohn's disease. In case of microscopic colitis all the imaging diagnostics has no use. The only one mean to establish the diagnosis is a histological assessment. What is more, in the period of remission the colon tissue could be normal. In this paper we discussed the traditional and contemporary intestine imaging methods in inflammatory bowel diseases. The conclusion is that the further progress in science offers a better imaging and, what is even more important, the more efficient diagnostics and treatment of these diseases.

Humans↗

PubMed2004

[Estimation of gastric mucosa morphological changes in subjects with asymptomatic Helicobacter pylori infection and family history of gastric cancer].

Helicobacter pylori is a known carcinogen but the natural history of gastric carcinoma development has not been recognized thoroughly and early diagnostics is difficult particularly in asymptomatic infection. The aim of own study was gastric mucosa morphological estimation in subjects with asymptomatic H. pylori infection. Investigations were performed in 60 subjects, aged 24-55 years with family history of gastric cancer and with asymptomatic (group I; n=30) and symptomatic infection (group II; n=30). The infection and its severity were confirmed with breath test with the use of 75 mg of 13C labelled urea and Olympus FANci-2 analyzer. Gastric mucosa macro- and microscopic state was evaluated according to 4-degree Sydney scale. In group II macroscopic changes were more pronounced than in group I (p=0.032); no such differences were seen in microscopic picture (p=0.625). The extent of macro- and microscopic changes demonstrated positive correlation with the results of breath test (group I: r=0.8169; group II: r=0.8393). In subjects with family history of gastric cancer H. pylori infection both, symptomatic and asymptomatic causes similar gastric mucosa histopathological changes including intestinal metaplasia. The degree of morphological changes demonstrates positive dependence with the severity of infection.

Adult↗

PubMed2004

[Assessment of Helicobacter pylori infection severity and immune response in different age groups].

In practice, breath and serologic tests are applied to confirm the diagnosis of H. pylori and for epidemiologic studies. The aim of the study is quantitative evaluation of the results of both tests in relation to the examined subjects' age, clinical symptoms and family history of gastric cancer. Investigations were carried out in 300 subjects, aged 16-70 years, 186 of them with asymptomatic H. pylori infection and 114 with family history of gastric cancer. The breath test was performed with 13C-labelled urea and Olympus FANci-2 analyzer and antibody titer was determined with ELISA in serologic test. The infection severity was the highest in the age group 31-40 years (result of the breath test 32.4+/-20.3/1000) and the lowest in the group aged 61-70 years (8.4+/-8.11/1000; p<0.01). The antibody titer was the highest at the age 21-30 years (89.6+/-39.5 U/ml) and significantly lower in the group over 60 years of age (31.0+/-27.2 U/ml; p<0.01). In subjects with asymptomatic infection the results of both tests were lower than in symptomatic infection in all age groups. No statistically significant differences were found between the subjects with and without family history of gastric cancer. H. pylori infection severity and immune response depend on the age of the examined subjects. H. pylori infection severity and immune response are lower in asymptomatic than in symptomatic subjects.

Adolescent↗