[Effects of glucocorticoid therapy on membrane markers of lymphocytes and monocytes in children with chronic idiopathic thrombocytopenic purpura].
The treatment with glucocorticoids brings about a decrease in the expression of Ia-like and LFA-J antigens on the membrane surface of peripheral blood lymphocytes and monocytes, diminution of the relative count of monocytes with fixed immunoglobulins (with Fc-receptors). A reduction of the count of B lymphocytes and monocytes with Ia and LFA-J antigens in the spleen was recorded. The hematologic effect attained in the treatment with glucocorticoids was determined by the combined effect of the drugs: by the blockade of monocyte/macrophage receptors and by the redistributiion++ action of prednisolone leading to the release of blood platelets from the bone marrow to the blood bed.
Adolescent↗