[Setup a model for study the interfere between chemokine and immunocyte].
OBJECTIVE: To investigated the effect of chemoattractant of rhTNF-alpha on TB-LCL. Set up a model for study the interaction between cytokine and B cells. METHOD: PTC were transfected with Epstein Barr virus, to get tonsil B lymphoblastic cell line(TB-LCL). RESULT: It was found rhTNF-alpha can chemotactic TB-LCL, in a dose-dependent manner and this chemotactic effect can be blocked by the neutralizing antibody E6 against TNF. CONCLUSION: This is an useful model in study the interfere between chemokine and immunocyte.
B-Lymphocytes↗