Biomedical subjects

Charles Arnold

Publications and source records attributed to Charles Arnold.

2 recordsLinked to original sources

PubMed2005

Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands.

A novel series of 2-anilino-3-phenylsulfonyl-6-methylpyridines was synthesized and evaluated as corticotropin-releasing factor receptor ligands. Structure-activity relationship studies focused primarily on optimization of the 3-phenylsulfonyl group. Compounds within this series were identified which showed potent binding affinity for the CRF1 receptor. Selected compounds were examined in a rat pharmacokinetic study and were found to have oral bioavailabilities ranging from 16 to 35%.

Administration, Oral↗

PubMed2002

Reducing errors in discharge medication lists by using personal digital assistants.

This study examined whether the number of errors in discharge medication lists at a psychiatric hospital would decrease when the practice of transcribing the lists by hand from physicians' discharge orders was replaced by the use of personal digital assistants (PDAs) to create and directly print out such lists. In a four-month period before the use of PDAs was introduced, 20 of the 110 hand-transcribed lists (22 percent) contained errors. In the four-month period after the use of PDAs was implemented, seven of the 90 PDA-generated lists (8 percent) contained errors. Use of a PDA may be helpful in providing safer patient care.

Computers, Handheld↗