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Biomedical subjects

Charles E Wall

Publications and source records attributed to Charles E Wall.

4 recordsLinked to original sources
PubMed2005

The results of superficial femoral, popliteal, and tibial artery stenting for peripheral vascular occlusive disease.

The purpose of this study was to evaluate the patentcy rates and physiological effectiveness of angioplasty and stenting as a primary therapy for superficial femoral (SFA), popliteal (POP), and tibial (TIB) arterial occlusive disease. Seventy-eight patients had stents placed in the infra-inguinal vessels between January 1, 2001, and July 31, 2004. We collected data on patient demographics, symptoms, as well as pre- and postprocedure ankle-brachial index (ABI) and angiographic findings. Patency rates at 6 months, 12 months, and 24 months were analyzed by life table methods. Thirty-one men and 47 women had a mean age of 68 years (range 36-94 years). Risk factors included diabetes in 50 per cent, hypertension in 79 per cent, smoking in 41 per cent, and end-stage renal disease in 10 per cent. The indications for intervention were claudication in 52 per cent and limb salvage in 48 per cent of patients. Stents were placed in the SFA in 54 patients (69%), in the POP in 15 patients (18%), and in the TIB artery in 6 patients (8%). Average follow-up was 11.2 months. The mean postprocedural increase in ABI was 0.29. The 6-month, 1-year, and 2-year primary patency rates were 83 per cent, 58 per cent, and 47 per cent, respectively. Limb salvage was achieved in 66 per cent of patients treated for limb-threatening ischemia. There was one major and three minor complications. Stenting of the infra-inguinal vessels has a low morbidity, high success rate, and acceptable patency and limb-salvage rates.

Adult↗
PubMed2004

The natural history of untreated penetrating diaphragm injury: an animal model.

BACKGROUND: Surgical repair of diaphragm injuries is rather straightforward, but diagnosis can be difficult. The natural history of diaphragm injury is quite controversial. Undoubtedly, many diaphragmatic injuries are missed at the initial evaluation. Some theories state that diaphragm injuries do not heal, and that all eventually lead to herniation. Current theories regarding uniform herniation of all diaphragm injuries are not supported by animal models. The authors developed a penetrating diaphragm injury model to study the natural history of this injury. METHODS: This study used 48 male Sprague-Dawley rats weighing 300-425 g. During the study, 24 of the rats received a 16-gauge needle puncture of the left diaphragm mimicking a small penetrating wound, whereas 24 of the rats received an injury produced with a 2.7-mm aortic punch, which created a defect comparable to a much larger penetrating wound. Half of the animals in each group were euthanized at 1 month, and the other half at 10 months. This allowed short- and long-term follow-up of the injuries. Gross inspection of the left diaphragm was performed after the animals were sacrificed via a thoracoabdominal incision. All diaphragms then were removed for examination. RESULTS: All the rats experienced perioperative recovery. None of the 24 rats with a 16-gauge needle injury had an injury at 1 month (n = 12) or 10 months (n = 12). No patent injury was noted in the aortic punch injury group (n = 12) sacrificed at 1 month. At 10 months, 1 of 12 animals had a small hepatic herniation through the aortic punch injury. All the injuries displayed adhesions to the underlying left hepatic lobe. CONCLUSIONS: The authors developed a penetrating diaphragm injury model to understand better the natural history of this injury. Spontaneous healing occurred in 98% of the animals. In this animal model, because the left lobe of the liver is present beneath the left diaphragm, healing without herniation usually occurs. A role may exist for nonoperative treatment of human right diaphragm injuries in clinical practice. This animal model may prove useful in further defining future management for these injuries.

Animals↗