Biomedical subjects

Charles F Shuler

Publications and source records attributed to Charles F Shuler.

21 records · Page 2Linked to original sources

PubMed2002

Celiac disease and recurrent aphthous stomatitis: a report and review of the literature.

Celiac disease (CD) is a condition related to the small intestine's intolerance to gluten. The diagnosis of CD can be difficult, especially because patients may exhibit a wide spectrum of signs and symptoms. It is important to identify this disease process early because affected individuals have an increased risk for developing lymphoma of the gut. Our objective was to evaluate whether patients with CD have a significantly higher prevalence of recurrent aphthous stomatitis compared with the general population, as some investigators have speculated. Therefore, we screened 61 patients with diagnosed CD for the presence of, or a positive history of, aphthous ulcerations. We then statistically compared this data with a randomly selected control population, matched for age and gender, but without CD. Our results demonstrated no significant differences between groups for age, gender, or prevalence of recurrent aphthous stomatitis.

Adult↗

PubMed2002

Application of problem-based learning to clinical dental education.

Problem-based learning provides a mechanism for learning in a manner that most closely simulates the future practice environment. PBL was initiated in medical education in the 1960s, and two-thirds of U.S. medical schools use PBL in their programs. The University of Southern California School of Dentistry has moved to the PBL model to give its dental students the knowledge base required to meet accreditation standards and to prepare them to be beginning general practitioners. This article explains how USC uses PBL in its dental curriculum.

Curriculum↗

PubMedDate not supplied

Mesencephalic trigeminal nucleus development is dependent on Krox-20 expression.

Krox-20, a C2H2-type zinc-finger transcription factor, plays an important role in rhombomere development. This study reveals that the Krox-20 null mutation impacts the development of mesencephalic trigeminal (Me5) neurons, a cell group traditionally thought to emerge from the mesencephalon. Based on cell counting studies, we show that Krox-20 null mutants have twice as many Me5 neurons relative to wildtypes at E15, but by birth have half the number of Me5 cells as wildtypes. TUNEL studies reveal a period of increased apoptosis from E17-P0 in mutants. The mutation does not result in differences in Me5 cell size, morphology, gene expression or peripheral projection patterns between genotypes, as demonstrated by retrograde tracing and Brn3a immunohistochemistry. The data suggest that Krox-20 regulates the period and extent of Me5 apoptosis, impacting the final number of Me5 neurons. The loss of Me5 in Krox-20-/- mice may highlight species-specific differences in the origin of these cells.

Animals↗