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Biomedical subjects

Chen-Yu Chen

Publications and source records attributed to Chen-Yu Chen.

5 recordsLinked to original sources

Are routine interventions necessary in normal birth?

Routine interventions during labor and birth, such as perineal shaving and enemas before vaginal delivery, continuous intrapartum electronic fetal monitoring (EFM), and episiotomy are prevalent in Taiwan, but they may not always be necessary. Numerous studies investigating these interventions have failed to find absolute benefits for women with uncomplicated and low-risk pregnancies. No evidence-based benefits support routine perineal shaving or enemas during labor for reducing the risk of perineal wound infection or neonatal infection. The use of EFM is associated with an increased rate of operative interventions (vacuum, forceps, cesarean delivery) but does not result in a significant decrease in the incidence of perinatal death or cerebral palsy. Routine episiotomy does not have demonstrable advantages over restrictive episiotomy in the frequency or severity of perineal damage or pelvic relaxation.

Delivery, Obstetric↗

Localized nodular synovitis of the knee: MR imaging appearance and clinical correlates in 21 patients.

OBJECTIVE: Localized nodular synovitis of the knee and pigmented villonodular synovitis are similar histologically. The purpose of this study was to evaluate the MR imaging appearance and clinical findings of localized nodular synovitis of the knee and to differentiate this condition from pigmented villonodular synovitis. MATERIALS AND METHODS: A retrospective review of MR imaging of the knee was performed in 21 patients with histologically confirmed localized nodular synovitis. Surgical excision of the lesion was performed in all patients. The MR imaging appearances of the lesions were defined, and the clinical and surgical findings were reviewed. RESULTS: All lesions presented as a solitary intraarticular mass. The mass originated from the synovial lining in different locations including the infrapatellar fat pad (n = 14), suprapatellar pouch (n = 5), and posterior aspect of the intercondylar notch (n = 2). A small (2.0-3.5 cm; mean diameter, 2.7 cm) ovoid mass (n = 13) was more common than a large (5.0-9.0 cm; mean diameter, 6.5 cm) polylobulated mass (n = 8). At surgery, a long pedicle attached the mass to the adjacent synovium in two patients, but this was observed on MR imaging in only one patient. The lesions showed intermediate (n = 15) or hyperintense (n = 6) signal intensity on T1-weighted images and heterogeneously high (n = 13) or low (n = 8) signal intensity with variable circular foci of low signal intensity on T2-weighted images. On T2-weighted images, linear regions of high signal intensity within the mass were seen in seven lesions. Prominent enhancement of the lesion with IV contrast administration was shown in all patients who were given contrast material (n = 10). Knee pain, joint swelling, and a palpable mass were the most frequent clinical manifestations. An acutely painful knee was noted in one patient who presented with torsion of an infrapatellar pedicle. Five patients complained of locking of the knee, but at physical examination, restricted terminal knee extension was noted in nine patients. CONCLUSION: Localized nodular synovitis of the knee predominantly involves the infrapatellar fat pad. It may produce symptoms related to mechanical derangement of the knee. Although there is no typical MR appearance for this lesion, many features help to differentiate it from pigmented villonodular synovitis.

Adult↗

Factors implicated in the outcome of pregnancies complicated by acute respiratory failure.

OBJECTIVE: To investigate factors predictive of the outcome of acute respiratory failure during pregnancy. STUDY DESIGN: We retrospectively reviewed the records of all pregnant women diagnosed with acute respiratory failure at a tertiary referral center from January 1, 1995, to September 30, 2000. Maternal characteristics, etiology of respiratory failure and treatment were compared between survivors and nonsurvivors. RESULTS: Twenty patients with acute respiratory failure were identified; 16 of them survived (mortality, 20%). Acute respiratory failure was diagnosed in the postpartum period in 16 (80%), and the majority of cases occurred in the first 2 postpartum days (93.8%). There was no statistically significant difference between the 2 groups in terms of patient characteristics, immediate precipitants of acute respiratory failure (including pneumonia, cardiogenic pulmonary edema, acute respiratory distress syndrome, asthma, pulmonary embolism and amniotic fluid embolism) and laboratory characteristics except for pH. However, patients who manifested disseminated intravascular coagulopathy (DIC) and sepsis as precipitating causes or complications of the immediate precipitating disease entities as well as initial loss of consciousness were predictive of poor maternal outcome. CONCLUSION: The immediate etiology of acute respiratory failure is not predictive of maternal outcome, but lower pH, initial loss of consciousness, DIC and sepsis are risk factors for maternal mortality.

Acute Disease↗

Prenatal three-dimensional/four-dimensional sonographic demonstration of facial dysmorphisms associated with holoprosencephaly.

In this report, we describe the prenatal use of 3-dimensional 4-dimensional (3D/4D) sonography to visualize the facial dysmorphisms associated with holoprosencephaly in 6 fetuses (2 with cyclopia, 1 with cebocephaly, and 3 with holoprosencephaly-premaxillary agenesis). Ultrafast MRI was also used. The 3D/4D sonographic images allowed easy, rapid, and precise prenatal evaluation of the facial dysmorphisms associated with holoprosencephaly; the MRI scans provided little additional information. The 3D/4D sonograms helped the parents visualize the abnormalities and facilitated their acceptance of perinatal genetic counseling.

Abnormalities, Multiple↗