Chia-Hsuan Lin | PubMed Health

PubMed2005

Optimal quantization method for uneven-phase diffractive optical elements by use of a modified iterative Fourier-transform algorithm.

A method based on an iterative Fourier-transform algorithm (IFTA) with phase optimization for phase-only multilevel diffractive optical elements (DOEs) is presented. Phase optimization by minimizing the mean-squared error composed of an amplitude-weighted probability-density function is performed in the IFTA iterations to ensure that the wavefront difference is minimized and thus to improve the DOEs' performance. Using the proposed method, we obtained a small standard deviation of diffraction efficiency of 20 uneven-phase DOEs, showing that DOEs with high diffraction efficiency did not vary significantly with the initial conditions. The simulation results of even- and uneven-phase four-level DOEs designed by use of direct and stepwise quantization IFTA methods are compared.

Journal Article↗

PubMedDate not supplied

Lipid nano/submicron emulsions as vehicles for topical flurbiprofen delivery.

The application of lipid nano/submicron emulsions as topical drug carrier systems for the percutaneous absorption of flurbiprofen was investigated. The lipid emulsions were made up of isopropyl myristate (IPM), soybean oil, or coconut oil as the oil phase, egg lecithin as the predominant emulsifier, and double-distilled water as the external phase. Stearylamine (SA) and deoxycholic acid (DA) also were used to produce positively and negatively charged emulsions. To evaluate the physicochemical properties of the lipid emulsions, particle size by laser light scattering, the image of atomic force microscopy, and relaxation time values by Nuclear Magnetic Resonance (NMR) were determined. The in vitro permeation data showed that incorporation of SA significantly reduced the topical delivery of flurbiprofen. On the other hand, incorporation of DA exhibited no or a negligible effect on drug permeation. Enhancement of drug absorption was observed when adding oleic acid as part of the oil phase. The in vivo topical application of flurbiprofen from selected lipid emulsions showed a similar trend to the in vitro status. Furthermore, the intersubject variability was considerably reduced by lipid emulsions than by aqueous suspensions in both the in vitro and in vivo experiments. The irritant profiles of lipid emulsions showed that IPM elicited higher irritation than soybean oil. The incorporation of oleic acid also produced skin disruption. The results in the present study suggest the feasibility of lipid emulsions for the topical delivery of flurbiprofen.

Administration, Topical↗